Non-invasive method and apparatus for measuring blood glucose concentration
First Claim
1. A method for measuring blood glucose concentration comprising the steps of:
- supplying a power source from a battery to a processing means, a digital display, a laser diode power supply, a detector and an optical unit by means of a power switch;
controlling said processing means so that said laser diode power supply gradually applies current to said laser diode at a stable voltage and temperature by means of a start/reset switch;
controlling said processing means so that a D/A converter coupled between said processing means and said laser diode power supply converts a digital control signal provided by said processing means into an analog control signal;
said analog control signal causing said laser diode power supply to supply current to said laser diode causing said laser diode to emit light of a wavelength appropriate for measuring a blood glucose concentration;
optically controlling, separating and combining said light emitted from said laser diode;
irradiating through an integrating sphere said optically controlled light to a blood vessel to measure said blood glucose concentration;
collecting by means of said integrating sphere said light absorbed, dispersed and diffusely reflected by blood after said light reaches said blood;
supplying said light collected by said integrating sphere to said detector which converts said light into an electrical analog signal which is supplied to a preamplifier which amplifies said electrical analog signal which is converted to a digital signal by an A/D converter;
transmitting said digital signal to said processing means;
calculating and computing said blood glucose concentration by comparing a calibration curve stored in a memory region of said processing means with said digital signal converted by said A/D converter;
displaying a calculated blood glucose concentration on said digital display.
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Abstract
A method and apparatus for measuring blood glucose concentration by irradiating blood vessels with electromagnetic radiation, where the method and apparatus uses near-infrared radiation diffuse-reflection laser spectroscopy. This invention uses electromagnetic radiation of a wavelength that is transmitted through the skin to the measurement region, for example, a blood vessel. Since skin is mostly composed of water (H2 O), which absorbs infrared radiation in nearly the entire infrared spectral range, only radiation from a certain, narrow portion of the infrared spectral range called the "water transmission window" is transmitted through the skin. The present invention uses electromagnetic radiation with a wavelength of 1.3 μm- 1.8 μm radiation from a semiconductor diode laser. When electromagnetic radiation of these wavelengths irradiates the skin, light is transmitted through the skin to the blood vessel where the light interacts with the heterogeneous components of the blood. The light transmitted to the blood is then diffusely reflected by the blood. The reflected light will have been modulated by the characteristic vibrations of the molecules which are major components of blood. The reflected light is detected and provided as a digital signal to a one-chip microcomputer. The one-chip microcomputer calculates a blood glucose concentration from the digital signal by reference to a calibration curve stored in the memory of the one-chip microcomputer. The one-chip microcomputer causes the calculated blood glucose concentration to be displayed on a digital display.
338 Citations
25 Claims
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1. A method for measuring blood glucose concentration comprising the steps of:
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supplying a power source from a battery to a processing means, a digital display, a laser diode power supply, a detector and an optical unit by means of a power switch; controlling said processing means so that said laser diode power supply gradually applies current to said laser diode at a stable voltage and temperature by means of a start/reset switch; controlling said processing means so that a D/A converter coupled between said processing means and said laser diode power supply converts a digital control signal provided by said processing means into an analog control signal; said analog control signal causing said laser diode power supply to supply current to said laser diode causing said laser diode to emit light of a wavelength appropriate for measuring a blood glucose concentration; optically controlling, separating and combining said light emitted from said laser diode; irradiating through an integrating sphere said optically controlled light to a blood vessel to measure said blood glucose concentration; collecting by means of said integrating sphere said light absorbed, dispersed and diffusely reflected by blood after said light reaches said blood; supplying said light collected by said integrating sphere to said detector which converts said light into an electrical analog signal which is supplied to a preamplifier which amplifies said electrical analog signal which is converted to a digital signal by an A/D converter; transmitting said digital signal to said processing means; calculating and computing said blood glucose concentration by comparing a calibration curve stored in a memory region of said processing means with said digital signal converted by said A/D converter; displaying a calculated blood glucose concentration on said digital display. - View Dependent Claims (2, 3)
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4. An apparatus for measuring blood glucose concentration comprising:
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processing means for controlling the flow of current supplied from a laser diode power supply to a laser diode assembly so that current is applied gradually and at stable voltage and temperature levels to said laser diode assembly, said processing means for calculating and computing a blood glucose concentration by comparing an electrical analog signal with a calibration curve stored in a memory of said processing means; a D/A converter for controlling the laser diode power supply by converting a digital control signal to an analog control signal, wherein said laser diode power supply applies a power source to said laser diode assembly which comprises a light source for a blood glucose measurement, and said laser diode assembly consists of a plurality of laser diodes for emitting light of different wavelengths or emitting light of the same wavelength, in accordance with the current supplied by said laser diode power supply; a temperature controller which controls the temperature of said plurality of laser diodes, said temperature controller being connected between said laser diode power supply and said laser diode assembly; an optical unit which optically controls, separates or combines the light emitted from said laser diode so that the light is emitted from a port in the apparatus; an integrating sphere which collects light dispersed and diffusely reflected from blood; a detector which converts light from said integrating sphere into an electrical analog signal and supplies said electrical analog signal to a preamplifier which amplifies said signal; and an A/D converter which converts said electrical analog signal into a digital signal, said digital signal provided to said processing means; and a digital display connected to said processing means which displays the calculated and computed blood glucose concentration dependent upon said digital signal provided to said processing means. - View Dependent Claims (5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25)
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Specification