Cardiovascular flow enhancer and method of operation

• US 5,267,940 A
• Filed: 05/06/1991
• Issued: 12/07/1993
• Est. Priority Date: 11/29/1989
• Status: Expired due to Term

• Current Assignee: Administrators Of The Tulane Educational Fund (ADMINISTRATORS|DAVID H. COY)
• Original Assignee: Administrators Of The Tulane Educational Fund (ADMINISTRATORS|DAVID H. COY)
• Inventors: Moulder, Peter V.
• Primary Examiner(s): Green, Randall L.
• Assistant Examiner(s): JONES, MARYBETH O
• Application Number:
  US07/695,946
• Time in Patent Office: 946 Days
• Field of Search: 623/1-3, 604/8, 604/9, 600/16, 600/17, 600/18, 600/36, 137/569
• US Class Current: 600/16
• CPC Class Codes: A61F 2/06 Blood vessels
• CPC Class Codes: A61M 2205/33 Controlling, regulating or measuring
• CPC Class Codes: A61M 2205/3303 Using a biosensor
• CPC Class Codes: A61M 2205/3334 Measuring or controlling the flow rate
• CPC Class Codes: A61M 2205/3337 Controlling, regulating pressure or flow by means of a valve by-passing a pump
• CPC Class Codes: A61M 2205/8243 by induction
• CPC Class Codes: A61M 39/228 with a tubular diaphragm constrictable by radial fluid force
• CPC Class Codes: A61M 60/148 in line with a blood vessel using resection or like techniques, e.g. permanent endovascular heart assist devices
• CPC Class Codes: A61M 60/152 branching on and drawing blood from a blood vessel
• CPC Class Codes: A61M 60/232 Centrifugal pumps
• CPC Class Codes: A61M 60/411 generated by an electromotor
• CPC Class Codes: A61M 60/515 Regulation using real-time patient data
• CPC Class Codes: A61M 60/546 of blood flow, e.g. by adapting rotor speed
• CPC Class Codes: A61M 60/833 Occluders for preventing backflow
• CPC Class Codes: A61M 60/861 Connections or anchorings for connecting or anchoring pumps or pumping devices to parts of the patient's body
• CPC Class Codes: A61M 60/873 specially adapted for wireless or transcutaneous energy transfer [TET], e.g. inductive charging
• CPC Class Codes: A61M 60/896 having flexible or resilient parts, e.g. flap valves

Abstract

An implanted cardiovascular assist pump is connected with the proximal descending thoracic aorta. The pump inlet is connected with the aorta at substantially the site of the first pressure/flow node from the heart. The pump outlet is connected at substantially the site of the last pressure/flow antinode before the heart. Control of pump speed varies blood flow through the pump. As a fail-safe mechanism, a pump shunt flow path is provided, through one of a variety of disclosed structures.

Claims

1. A method of implanting a cardiovascular flow enhancer comprising the steps of:

providing an implantable centrifugal pump having an inlet and an outlet;

providing an inlet conduit;

providing an outlet conduit;

connecting the inlet conduit with the pump inlet and with the descending thoracic aorta at substantially the site of the pressure node for blood from the heart to receive blood from the descending thoracic aorta and direct blood to the pump; and

connecting the outlet conduit with the pump outlet and with the descending thoracic aorta at a point downstream from the inlet connection to discharge blood into the aorta.

2. The method of implanting a cardiovascular flow enhancer as claimed in claim 1 wherein the outlet conduit is connected with the descending thoracic aorta at substantially the last blood flow and pressure antinode before the heart of the descending thoracic aorta.

3. The method of implanting a cardiovascular flow enhancer as claimed in claim 1 in which the pump is located above the diaphragm in the lower left hemithorax of the posterior chest.

4. The method of implanting a cardiovascular flow enhancer as claimed in claim 1 in which the pump is located in the upper left hemithorax of the posterior chest.

5. A method of implanting a cardiovascular flow enhancer comprising the steps of:

providing an implantable centrifugal pump having an inlet and an outlet;

providing an inlet conduit;

providing an inlet conduit;

providing an outlet conduit;

connecting the inlet conduit with the pump inlet and with the descending thoracic aorta at substantially the site of the pressure node for blood from the heart to receive blood from the aorta and direct blood to the pump; and

connecting the outlet conduit with the pump outlet and with the descending thoracic aorta at a point downstream from the inlet connection to discharge blood into the aorta;

providing an alternative flow path in shunt with the pump to provide an emergency blood flow path around the pump.

6. The method of implanting a cardiovascular flow enhancer as claimed in claim 5 wherein a section of the thoracic aorta is connected in shunt with the pump.

7. The method of implanting a cardiovascular flow enhancer as claimed in claim 5 further comprising providing a controllable occluder operatively associated with the alternate flow path, the occluder being operable to minimize blood flow through the flow path in shunt with the pump during normal operation of the pump and to allow greater blood flow through the shunt conduit when blood flow through the pump falls below a minimum level.

8. The method of implanting a cardiovascular flow enhancer as claimed in claim 5 wherein the alternate flow path comprises an expandable graft conduit having an inner diameter permitting minimal blood flow through the shunt conduit when the pump is in normal operation, the expandable graft conduit being expandable to allow greater blood flow through the conduit when blood flow through the pump falls below a minimum level.

9. The method of implanting a cardiovascular flow enhancer as claimed in claim 5 wherein the alternate flow path includes a check valve to prevent back flow through the alternate flow path, and wherein the check valve is openable to allow blood flow through the alternate flow path when pressure upstream of the check valve reaches a predetermined maximum level.

10. A method of implanting a cardiovascular flow enhancer comprising the steps of:

providing a centrifugal pump having an inlet and an outlet;

connecting the pump inlet to receive blood from the descending thoracic aorta from a site at substantially the first quiescent section of the descending thoracic aorta downstream from the brachiocephalic arteries; and

connecting the pump outlet to discharge blood to the descending thoracic aorta at a point downstream from the inlet connection.

11. A method of implanting a cardiovascular flow enhancer comprising the steps of:

providing a centrifugal pump having an inlet and an outlet;

connecting the pump inlet to receive blood from the proximal descending thoracic aorta; and

connecting the pump outlet to discharge blood to the descending thoracic aorta at a point downstream from the inlet connection.

12. The method of implanting a cardiovascular flow enhancer as claimed in claim 11 wherein the pump inlet is connected to receive blood from a site about one to twelve centimeters downstream from the juncture of the left subclavian artery and the aorta.

13. A method of improving cardiovascular performance comprising the steps of:

providing a centrifugal pump having an inlet and an outlet;

connecting the pump inlet to receive blood from the first pressure and flow node of the descending thoracic aorta; and

connecting the pump outlet to discharge blood to the descending thoracic aorta at a point downstream of the first connection.

14. The method of improving cardiovascular performance of claim 13 further comprising:

providing an inlet conduit having one end in fluid communication with the pump inlet;

providing an outlet conduit having one end in fluid communication with the pump outlet;

connecting the other end of the inlet conduit to the descending thoracic aorta substantially at the first nodal point; and

connecting the other end of the outlet conduit to the descending thoracic aorta at a point downstream of the connection of the inlet conduit to the descending thoracic aorta.

15. The method of improving cardiovascular performance of claim 14 further comprising providing an inlet chamber in fluid connection with the pump inlet and the inlet conduit, an outlet chamber in fluid communication with the outlet conduit and the pump outlet, and a housing holding the pump, inlet chamber and outlet chamber.

16. The method of improving cardiovascular performance of claim 15 further comprising providing an emergency shunt flow path between the inlet chamber and the outlet chamber, the emergency shunt flow path being held within said housing.

17. The method of improving cardiovascular performance of claim 15 further comprising providing a drive motor within the housing to drive the pump.

18. The method of improving cardiovascular performance of claim 13 further comprising the steps of:

sensing physiological conditions of the subject; and

varying pump speed in accordance with the sensed physiological conditions of the subject.

19. A cardiovascular flow enhancer comprising:

a centrifugal pump having an inlet and an outlet;

an inlet conduit having one end in fluid communication with the pump inlet;

an outlet conduit having one end in fluid communication with the pump outlet;

the centrifugal pump, inlet conduit and outlet conduit defining a primary blood flow path; and

a parallel flow conduit extending between the inlet and outlet conduits to provide an emergency blood flow path for a level of blood flow when blood flow through the pump falls below a minimum level and to provide a secondary blood flow path for a lower level of blood flow during normal operation of the pump, the parallel flow conduit being in parallel with the primary blood flow path the cardiovascular flow enhancer further comprising a housing made of a biologically inert material within which the centrifugal pump and parallel flow conduit are held, said housing being configured and sized to be implanted in a living body.

20. The cardiovascular flow enhancer of claim 19 further comprising a controllable occluder operatively associated with the parallel flow conduit to limit blood flow through the parallel flow conduit during normal operation of the pump and to allow greater blood flow through the parallel flow conduit when blood flow through the pump falls below a minimum level.

21. The cardiovascular flow enhancer of claim 19 wherein the parallel flow conduit is expandable and has an inner diameter permitting minimal blood flow through the shunt conduit when the pump is in normal operation, the parallel flow conduit being expandable to allow greater blood flow through the conduit when blood flow through the pump falls below a minimum level.

22. The cardiovascular flow enhancer of claim 19 further comprising a flap valve to limit blood flow through the parallel flow conduit, the flap valve being openable to allow blood flow through the parallel flow conduit when pressure upstream of the flap valve reaches a predetermined maximum level.

23. The cardiovascular flow enhancer of claim 19 wherein the inlet conduit defines an inlet chamber in fluid communication with the pump inlet and the outlet conduit defines an outlet chamber in fluid communication with the pump outlet, the inlet and outlet chambers being held within the housing and the parallel flow conduit extending between the inlet chamber and the outlet chamber.