Drug delivery by multiple frequency phonophoresis
First Claim
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1. A method of enhancing diffusion of a substance through material comprising the steps of:
- a) providing said substance proximate said material;
b) providing a first component of ultrasonic energy to said substance, said first component of ultrasonic energy having a first frequency;
c) providing a second component of ultrasonic energy to said substance simultaneous with said first component of ultrasonic energy, said second component of ultrasonic energy having a second frequency, said second frequency differing from said first frequency, whereby diffusion of said substance through said material is enhanced.
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Abstract
The present invention provides a method and apparatus for enhancing the diffusion of a substance to a local area of material or tissue by providing ultrasonic energy to the substance and material in two or more distinct frequencies simultaneously. Each of the distinct frequencies of ultrasonic energy is chosen to enhance permeation of the substance through one or more diffusion rate-limiting sections of the material.
305 Citations
13 Claims
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1. A method of enhancing diffusion of a substance through material comprising the steps of:
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a) providing said substance proximate said material; b) providing a first component of ultrasonic energy to said substance, said first component of ultrasonic energy having a first frequency; c) providing a second component of ultrasonic energy to said substance simultaneous with said first component of ultrasonic energy, said second component of ultrasonic energy having a second frequency, said second frequency differing from said first frequency, whereby diffusion of said substance through said material is enhanced. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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11. A method of enhancing diffusion of a substance through material comprising the steps of:
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a) providing said substance proximate said material; b) providing a first component of ultrasonic energy to said substance, said first component of ultrasonic energy having a first frequency; c) selecting said first frequency to enhance diffusion of said substance through a first portion of said material; d) providing a second component of ultrasonic energy to said substance simultaneous with said first component of ultrasonic energy, said second component of ultrasonic energy having a second frequency; e) selecting said second frequency to enhance diffusion of said substance through a second portion of said material, whereby diffusion of said substance throughout said first and second portions of said material is enhanced. - View Dependent Claims (12, 13)
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Specification