Ultrasonically sealed transdermal drug delivery systems
First Claim
1. A method of making a transdermal drug delivery device said device comprising a backing layer and a second layer, said second layer contacting said backing layer and adhered thereto with a seal, said device further comprising an active agent located within said second layer or within a region defined by said backing layer and said second layer, wherein said backing layer is impermeable to said active agent and said second layer is permeable to said active agent or an activated form of said active agent, said method comprising forming said seal ultrasonically by applying an ultrasonic frequency of about 18 kHz to about 22 kHz in a desired sealing pattern for a period of about 250 msec to about 950 msec along with a substantially simultaneous pressure of about 318 lbs to about 566 lbs.
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Accused Products
Abstract
A method of sealing transdermal drug delivery system components together which comprises contacting the surfaces of the components to be sealed together with each other and exposing the contacted surfaces to ultrasonic forces while said surfaces are still in contact to produce a seal of said surfaces in a predetermined manner.
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Citations
11 Claims
- 1. A method of making a transdermal drug delivery device said device comprising a backing layer and a second layer, said second layer contacting said backing layer and adhered thereto with a seal, said device further comprising an active agent located within said second layer or within a region defined by said backing layer and said second layer, wherein said backing layer is impermeable to said active agent and said second layer is permeable to said active agent or an activated form of said active agent, said method comprising forming said seal ultrasonically by applying an ultrasonic frequency of about 18 kHz to about 22 kHz in a desired sealing pattern for a period of about 250 msec to about 950 msec along with a substantially simultaneous pressure of about 318 lbs to about 566 lbs.
Specification