Determining the nature of brain lesions by electroencephalography

• US 5,269,315 A
• Filed: 08/16/1991
• Issued: 12/14/1993
• Est. Priority Date: 08/16/1991
• Status: Expired due to Term

• Current Assignee: Regents of the University of California (University of California)
• Original Assignee: Regents of the University of California (University of California)
• Inventors: Cook, Ian A., Leuchter, Andrew F.
• Primary Examiner(s): Kamm, William E.
• Assistant Examiner(s): Getzow, Scott M.
• Application Number:
  US07/745,872
• Time in Patent Office: 851 Days
• Field of Search: 128/731, 128/732
• US Class Current: 600/544
• CPC Class Codes: A61B 5/374 Detecting the frequency distribution of signals, e.g. detecting delta, theta, alpha, beta or gamma waves
• CPC Class Codes: A61B 5/4088 Diagnosing of monitoring cognitive diseases, e.g. Alzheimer, prion diseases or dementia

Abstract

Determining brain lesions by quantified electroencephalography is effected by obtaining absolute power data in a primary frequency domain for a brain region. Power data in the primary frequency domain in relation to power in a secondary frequency domain is determined. The two sets of data are related to obtain a value representative of the electrical output in the brain region. The representative value is compared to a selected base value and quantified departures are mapped topographically. This map is used to identify and assess lesions associated with disorders and afflictions including dementia and demyelinating diseases.

Claims

1. A method of determining the electrical output of a brain region in the head of a subject comprising obtaining first data representative of energy in the brain region in a primary frequency domain, determining second data representative of energy in the primary frequency domain substantially simultaneously relative to the energy in a secondary frequency domain, and relating the first data with the second data thereby obtaining a value representative of electrical output in the brain region.

2. A method of determining the electrical output of a brain region in the head of a subject comprising obtaining first data representative of energy in the brain region in a primary frequency domain, determining second data representative of energy in the primary frequency domain relative to the energy in a secondary frequency domain, and relating the first data with the second data thereby obtaining a value representative of electrical output in the brain region, wherein relating is effected by determining the first data and second data relative to a selected base value and wherein when the first data and the second data both increase or decrease relative to the selected base value, a concordance condition is indicated, and wherein when one of the first data and the second data respectively increase or decrease relative to the selected base while the other of the first data or second data, respectively, is oppositely directed relative to the selected base, a discordance condition is indicated.

3. A method as claimed in claim 2 including providing a selected base for the first data and a selected base for the second data.

4. A method as claimed in claim 2 wherein the first data are compared to a selected base value of the first data and the second data are compared to a selected base value of the second data thereby to obtain respectively either the concordance or discordance indication, and wherein the discordance and concordance is established in the primary frequency domain.

5. A method as claimed in claim 2 including obtaining a quantified value of the amount of departure of the discordance indication and the concordance indication by determining the amount of departure from the selected base.

6. A method as claimed in claim 5 including mapping topographically the quantified value over the brain region.

7. A method as claimed in claim 5 including having multiple primary frequency domains and including mapping the quantified value for multiple primary frequency domains.

8. A method as claimed in claim 5 including displaying a topographical map of the quantified value in a primary frequency domain.

9. A method as claimed in claim 5 wherein the primary frequency domain includes at least one of a delta region and a theta region.

10. A method as claimed in claim 2 wherein the first data are obtained from energy measured by selected electrode channels, and locating the selected electrode channels strategically about the brain.

11. A method as claimed in claim 2 wherein the first data are an absolute power, and the second data are a relative power, the absolute power being power measured by selected electrode channels over the primary frequency domain and the relative power being the distribution of power in the primary frequency domain relative to the power in the secondary frequency domain in the selected electrode channels.

12. A method as claimed in claim 2 including comparing the representative value with a selected base representative of the brain region and assessing from the comparison the physiology in the brain region.

13. A method as claimed in claim 2 including diagnosing from the representative value the existence or non-existence of a brain lesion characterized by at least one of the disorders indicated by dementia, such disorders being selectively multi-infarct dementia, Alzheimer'"'"'s disease, Pick'"'"'s disease or a demyelinating disease, selectively, multiple sclerosis.

14. A method as claimed in claim 2 including normalizing the effect of a selected energy distribution in the brain region, such region being selectively adjacent to at least one of the ears of the subject, the normalizing being effected by determining an energy measurement of different electrodes relative to data of at least one other electrode.

15. A method of determining the electrical output of a brain region in the head of a subject comprising obtaining first data representative of energy in the brain region in a primary frequency domain, determining second data representative of energy in the primary frequency domain relative to the energy in a secondary frequency domain, and relating the first data with the second data thereby obtaining a value representative of electrical output in the brain region, wherein the first data are divided by a selected first data value, and the second data are divided by a selected second data value thereby to obtain a normalized base value for normalizing the first data, and a normalized base for normalizing the second data, respectively, and wherein the first data relative to the normalized base value of the first data and the second data relative to the normalized base value of the second data yields concordance and discordance indications.

16. A method as claimed in claim 15 including employing a selected percentage of the normalized base value of the first data as a first selected base value, and employing a selected percentage of the normalized base value of the second data as a second selected base value and wherein when the first data are relatively less than the first selected base value and the second data are relatively greater than the second selected base value, respectively, a discordance is indicated, and wherein when the first selected data is increased relative to the first selected base value and the second data is relatively increased relative to the second selected base value, a concordance is indicated.

17. A method of determining the electrical output of a brain region in the head of a subject comprising obtaining first data representative of energy in the brain region in a primary frequency domain, determining second data representative of energy in the primary frequency domain relative to the energy in a secondary frequency domain, and relating the first data with the second data thereby obtaining a value representative of electrical output in the brain region, wherein the first data are an absolute power, and the second data are a relative power, the absolute power being power measured by selected electrode channels over the primary frequency domain and the relative power being the distribution of power in the primary frequency domain relative to the power in the secondary frequency domain in the selected electrode channels.

18. A method as claimed in claim 17 wherein relating the absolute power and the relative power is defined by the combination of the absolute power and relative power such that the relative power at a selected primary frequency domain is equal to the absolute power at the selected primary frequency domain divided by the power for the secondary frequency domain.

19. A method of determining the electrical output of a brain region in the head of a subject comprising obtaining first data representative of energy in the brain region in a primary frequency domain, determining second data representative of energy in the primary frequency domain substantially simultaneously relative to the energy in a secondary frequency domain, and relating the first data with the second data thereby obtaining a representative value of electrical output in the brain region, including comparing the representative value with a selected base representative of the brain region and assessing from the comparison the physiology in the brain region.

20. A method as claimed in claim 19 wherein the first data are obtained from energy measured by selected electrode channels, and locating the selected electrode channels strategically about the brain.

21. A method as claimed in claim 20 wherein multiple channels are obtained by locating multiple electrodes over the head of the subject in strategic locations about the head, obtaining data in an analog form from the electrodes, digitizing the analog data from the electrodes, and subjecting the digitized data to Fourier Transformation to obtain absolute power for each channel in the primary frequency domain.

22. A method as claimed in claim 21 including obtaining a relative power for each channel, such relative power being obtained by dividing the absolute power in the primary frequency domain by the absolute power in the secondary frequency domain.

23. A method as claimed in claim 20 wherein the energy is measured by the electrode for each channel, the energy measurement being obtained with reference to at least one other electrode located on the subject.

24. A method as claimed in claim 23 wherein the energy measured by the electrodes for each channel is obtained with reference to multiple electrodes about the head.

25. A method of determining the electrical output of a brain region in the head of a subject comprising obtaining first data representative of energy in the brain region in a primary frequency domain, determining second data representative of energy in the primary frequency domain relative to the energy in a secondary frequency domain, and relating the first data with the second data thereby obtaining a representative value of electrical output in the brain region, including diagnosing from the representative value the existence or non-existence of a brain lesion characterized by at least one of the disorders indicated by dementia, such disorders being selectively multi-infarct dementia, Alzheimer'"'"'s disease, Pick'"'"'s disease or a demyelinating disease, selectively, multiple sclerosis.

26. A method of determining the electrical output of a brain region in the head of a subject comprising obtaining first data representative of energy in the brain region in a primary frequency domain, determining second data representative of energy in the primary frequency domain relative to the energy in a secondary frequency domain, and relating the first data with the second data thereby obtaining a value representative of electrical output in the brain region, including normalizing the effect of a selected energy distribution in the brain region, such region being selectively adjacent to at least one of the ears of the subject, the normalizing being effected by determining an energy measurement of different electrodes relative to data of at least one other electrode.

27. A method of determining the electrical output of a brain region in the head of a subject comprising obtaining first data representative of energy in the brain region in a primary frequency domain, substantially simultaneously determining second data representative of energy in the primary frequency domain relative to the energy in a secondary frequency domain, relating the first data with the second data thereby obtaining a value representative of electrical output in the brain region, and obtaining a brain map of the representative value.

28. A method of determining the electrical output of a brain region in the head of a subject comprising obtaining first data representative of energy in the brain region in a primary frequency domain, determining second data representative of energy in the primary frequency domain relative to the energy in a secondary frequency domain, and relating the first data with the second data thereby obtaining a representative value of electrical output in the brain region, and obtaining a brain map of the representative value including obtaining a normalized base value for the first data and a normalized base for the second data respectively, obtaining simultaneously selected base values from the normalized base values and obtaining the representative value based on departures from the selected base values.

29. A method of determining the electrical output of a brain region in the head of a subject comprising obtaining first data representative of energy in the brain region in a primary frequency domain, determining second data representative of energy in the primary frequency domain relative to the energy in a secondary frequency domain, and relating the first data with the second data thereby obtaining a representative value of electrical output in the brain region, and obtaining a brain map of the representative value including comparing the representative value with a simultaneously obtained selected base representative of the brain region and assessing from the comparison the physiology in the brain region.

30. A method of determining the electrical output of a brain region in the head of a subject comprising obtaining first data representative of energy in the brain region in a primary frequency domain, substantially simultaneously determining second data representative of energy in the primary frequency domain relative to the energy in a secondary frequency domain, normalizing the first data, normalizing the second data, selecting a simultaneously obtained base value relative to the respective normalizations, determining departures of the first data and the second data from the respective selected base values, and relating the departures thereby to obtain a brain map representative of electrical output in the brain region.

31. A method of determining the electrical output of a brain region in the head of a subject comprising obtaining first data representative of energy in the brain region in a primary frequency domain, determining second data representative of energy in the primary frequency domain relative to the energy in a secondary frequency domain, normalizing the first data, normalizing the second data, selecting a base value relative to the respective normalizations, determining departures of the first data and the second data from the respective selected base values, and relating the departures thereby to obtain a brain map representative of electrical output in the brain region, including having multiple primary frequency domains and including effecting mapping for the multiple primary frequency domains.

32. A method as claimed in claim 31 including displaying a topographical map of the representative values in a primary frequency domain.

33. A method of determining the electrical output of a brain region in the head of a subject comprising measuring an absolute power in the brain region in a primary frequency domain, substantially simultaneously determining a relative power in the primary frequency domain relative to the absolute power in a secondary frequency domain, normalizing the absolute power, normalizing the relative power, selecting a simultaneously obtained base value relative to the respective normalizations, determining departures of the absolute power and the relative power from the respective selected base values, and relating the departures thereby to obtain a cordance brain map representative of electrical output in the brain region.

34. A method of determining the electrical output of a brain region in the head of a subject comprising measuring an absolute power in the brain region in a primary frequency domain, determining a relative power in the primary frequency domain relative to the absolute power in a secondary frequency domain, normalizing the absolute power, normalizing the relative power, selecting a base value relative to the respective normalizations, determining departures of the absolute power and the relative power from the respective selected base values, and relating the departures thereby to obtain a cordance brain map representative of electrical output in the brain region, including obtaining a topographical map of the representative values in a primary frequency domain.

35. A method as claimed in claim 34 wherein the primary frequency domain includes one of a delta region and a theta region, and the secondary frequency domain is selectively at least both of the delta and theta regions.

36. A method as claimed in claim 35 wherein the absolute power is obtained from selected electrode channels, and locating the selected electrode channels strategically about the brain.

37. Apparatus for determining the electrical output of a brain region in the head of a subject comprising means for obtaining first data representative of an energy in the brain region in a primary frequency domain, means for determining substantially simultaneously second data representative of energy in the primary frequency domain relative to the energy in a secondary frequency domain, and means for relating the first data with the second data thereby obtaining a value representative of electrical output in the brain region.

38. Apparatus as claimed in claim 37 including means for comparing the first data to a simultaneously obtained selected base value of the first data and means for comparing the second data to a simultaneously obtained selected base value of the second data.

39. Apparatus as claimed in claim 37 including electrode channels for location about the head and wherein the first data are absolute power, and the second data are relative power, the absolute power being power from a selected electrode channel over the primary frequency domain and the relative power being the distribution of power in the primary frequency relative to a secondary frequency domain in the selected electrode channel.

40. Apparatus as claimed in claim 39 including means for measuring the energy by the electrode for each channel, and means for obtaining the energy measurement with reference to at least one other electrode about the subject.

41. Apparatus for determining the electrical output of a brain region in the head of a subject comprising means for obtaining first data representative of an energy in the brain region in a primary frequency domain, means for determining second data representative of energy in the primary frequency domain relative to the energy in a secondary frequency domain, and means for relating the first data with the second data thereby obtaining a value representative of electrical output in the brain region, including means for determining a selected base value, the value being selectively normalized, means for relating the first data and second data relative to the selected base value, and means for determining selectively concordance and discordance conditions of the first data and second data relative to the selected base value.

42. Apparatus as claimed in claim 41 including means for determining a selected base value for the first data and a selected base value for the second data.

43. Apparatus as claimed in claim 41 including means for comparing the first data to a selected base value of the first data and means for comparing the second data to a selected base value of the second data.

44. Apparatus as claimed in claim 43 including means for quantifying an amount of a departure of the first data from a selected base value and the amount of departure of the second data from a selected base value.

45. Apparatus as claimed in claim 44 including means for mapping the quantified value over the brain region.

46. Apparatus for the method as claimed in claim 44 including means for selecting multiple primary frequency domains and including means for mapping the quantified value for multiple primary frequency domains.

47. Apparatus for the method as claimed in claim 44 including means for displaying a topographical map of the quantified value in a primary frequency domain.

48. Apparatus as claimed in claim 41 including electrode channels for location about the head and wherein the first data are absolute power, and the second data are relative power, the absolute power being power from a selected electrode channel over the primary frequency domain and the relative power being the distribution of power in the primary frequency relative to a secondary frequency domain in the selected electrode channel.

49. Apparatus for determining the electrical output of a brain region in the head of a subject comprising means for obtaining first data representative of an energy in the brain region in a primary frequency domain, means for determining second data representative of energy in the primary frequency domain relative to the energy in a secondary frequency domain, and means for relating the first data with the second data thereby obtaining a value representative of electrical output in the brain region including means for comparing the first data to a selected base value of the first data and means for comparing the second data to a selected base value of the second data, including means for quantifying an amount of a departure of the first data from a selected base value and the amount of departure of the second data from a selected base value.

50. Apparatus as claimed in claim 49 including means for mapping the quantified value over the brain region.

51. Apparatus for the method as claimed in claim 49 including means for selecting multiple primary frequency domains and including means for mapping the quantified value for multiple primary frequency domains.

52. Apparatus for the method as claimed in claim 49 including means for displaying a topographical map of the quantified value in a primary frequency domain.