Method for transvenously accessing the pericardial space via the right auricle for medical procedures

• US 5,269,326 A
• Filed: 10/24/1991
• Issued: 12/14/1993
• Est. Priority Date: 10/24/1991
• Status: Expired due to Fees

• Current Assignee: Georgetown University
• Original Assignee: Georgetown University
• Inventors: Verrier, Richard L.
• Primary Examiner(s): Kamm, William E.
• Application Number:
  US07/782,310
• Time in Patent Office: 782 Days
• Field of Search: 604/22, 604/27, 604/28, 604/52, 604/53, 604/93, 604/96, 604/264, 604/272, 604/280-283, 606/185, 128/642, 128/654, 128/768
• US Class Current: 600/374
• CPC Class Codes: A61M 2210/122 Pericardium
• CPC Class Codes: A61M 25/01 Introducing, guiding, advancing, emplacing or holding catheters A61M25/10 takes precedence
• CPC Class Codes: A61N 1/05 for implantation or insertion into the body, e.g. heart electrode A61N1/06 takes precedence
• CPC Class Codes: A61N 1/0587 Epicardial electrode systems; Endocardial electrodes piercing the pericardium
• CPC Class Codes: A61N 1/306 Arrangements where at least part of the apparatus is introduced into the body
• CPC Class Codes: A61P 9/00 Drugs for disorders of the cardiovascular system

Abstract

A method for placing various types of catheters into the pericardial space takes advantage of the fact that the right auricle is a thin-walled, low-pressure structure which can be readily penetrated without damaging the pericardium or the epicardium. The method avoids surgical trauma and the risks of general anesthesia and infection. A catheter is guided downstream through one of the venae cavae to the right atrium. Once inside the right atrium, the catheter is passed into the right auricle. The wall at the apex of the right auricle is then pierced to gain access to the pericardial space. The method can be used, for example, to provide electrical stimuli to the heart (e.g., for pacing, cardioversion, and defibrillation), to pick-up an ECG signal, to deliver pharmacologic agents to the heart, to improve vascularization, to remove pericardial fluid for analysis or pericardiocentesis, or to inject a radio-labelled or echo-sensitive dye into the pericardial space for precision fluid imaging.

Claims

1. A method for transvenously accessing the pericardial space between a heart and its pericardium in preparation for a medical procedure, said method comprising the following steps:

(a) guiding a catheter downstream through one of the venae cavae to the right atrium;

(b) guiding said catheter through the right atrium and into the right auricle; and

(c) accessing the pericardial space with said catheter by penetrating through the wall of the right auricle.

2. The method of claim 1, wherein said one of the venae cavae is the superior vena cava.

3. The method of claim 2, wherein the catheter is introduced into the superior vena cava via a peripheral vein.

4. The method of claim 1, wherein said one of the venae cavae is the inferior vena cava.

5. The method of claim 4, wherein the catheter is introduced into the inferior vena cava via a peripheral vein.

6. A method for transvenously delivering a pharmacologic agent to the heart, said method comprising the following steps:

(a) guiding a catheter downstream through one of the venae cavae to the right atrium;

(b) guiding said catheter through the right atrium and into the right auricle;

(c) accessing the pericardial space with said catheter by penetrating through the wall of the right auricle; and

(d) introducing the pharmacologic agent into the pericardial space via said catheter.

7. The method of claim 6, further comprising the steps of:

(e) passing an electrode through said catheter and into the pericardial space; and

(f) delivering electrical energy to the heart muscle through said electrode to iontophoretically enhance the delivery of the pharmacologic agent.

8. A method for monitoring electrical activity of the heart, said method comprising the following steps:

(a) guiding an electrode downstream through one of the venae cavae to the right atrium;

(b) guiding said electrode through the right atrium and into the right auricle;

(c) inserting said electrode into the pericardial space by penetrating through the wall of the right auricle; and

(d) detecting electrical energy with said electrode.

9. A method for delivering electrical stimuli to the heart, said method comprising the following steps:

(a) guiding an electrode downstream through one of the venae cavae to the right atrium;

(b) guiding said electrode through the right atrium and into the right auricle;

(c) inserting said electrode into the pericardial space by penetrating through the wall of the right auricle; and

(d) delivering the electrical stimuli to the heart muscle via said electrode.

10. A method for performing pericardiocentesis, said method comprising the following steps:

(a) guiding a catheter downstream through one of the venae cavae to the right atrium;

(b) guiding said catheter through the right atrium and into the right auricle;

(c) accessing the pericardial space with said catheter by penetrating through the wall of the right auricle; and

(d) withdrawing a fluid from the pericardial space.

11. A diagnostic method for use with the heart, said method comprising the following steps:

(a) guiding a catheter downstream through one of the venae cavae to the right atrium;

(b) guiding said catheter through the right atrium and into the right auricle;

(c) accessing the pericardial space with said catheter by penetrating through the wall of the right auricle;

(d) sampling the pericardial fluid; and

(e) analyzing said sample of the pericardial fluid for diagnostic purposes.

12. A method for diagnostic imaging of the heart, said method comprising the following steps:

(a) guiding a catheter downstream through one of the venae cavae to the right atrium;

(b) guiding said catheter through the right atrium and into the right auricle;

(c) accessing the pericardial space with said catheter by penetrating through the wall of the right auricle;

(d) injecting an imaging fluid into the pericardial space; and

(e) monitoring said imaging fluid with an external sensing device.

13. A method for transvenously performing a medical procedure on a heart, the method comprising the following steps:

(a) guiding a catheter downstream through one of the venae cavae to the right atrium;

(b) guiding said catheter through the right atrium and into the right auricle;

(c) accessing a pericardial space between the heart and its pericardium with said catheter by penetrating through the wall of the right auricle; and

(d) performing the medical procedure on the heart via the pericardial space.