Sample tube entry port for a chemical analyzer

• US 5,270,211 A
• Filed: 07/16/1992
• Issued: 12/14/1993
• Est. Priority Date: 07/16/1992
• Status: Expired due to Term

• Current Assignee: ALFA Wassermann Incorporated (Alfasigma S.p.A.)
• Original Assignee: Schiapparelli Biosystems, Inc.
• Inventors: Weyrauch, Bruce, Kelln, Norman, Loughlin, Kelsey
• Primary Examiner(s): Housel, James C.
• Assistant Examiner(s): BHAT, NINA NMN
• Application Number:
  US07/916,222
• Time in Patent Office: 516 Days
• Field of Search: 422/63, 422/64, 422/100, 436/43, 436/49, 436/54, 436/180, 356/246, 73/863.23, 73/863.24, 73/864.85, 73/864.86, 73/864.87, 73/863.83
• US Class Current: 436/43
• CPC Class Codes: G01N 2035/00495 Centrifuges
• CPC Class Codes: G01N 2035/00752 bar codes
• CPC Class Codes: G01N 2035/0093 random access not determined by physical position
• CPC Class Codes: G01N 2035/0441 for samples
• CPC Class Codes: G01N 2035/0443 for reagents
• CPC Class Codes: G01N 2035/0448 composed of interchangeable ring elements
• CPC Class Codes: G01N 2035/0449 using centrifugal transport of liquid
• CPC Class Codes: G01N 2035/0465 Loading or unloading the conveyor
• CPC Class Codes: G01N 2035/0493 Locating samples; identifying different tube sizes
• CPC Class Codes: G01N 2035/1025 Fluid level sensing
• CPC Class Codes: G01N 2035/1086 Cylindrical, e.g. variable angle
• CPC Class Codes: G01N 35/0092 Scheduling
• CPC Class Codes: G01N 35/025 having a carousel or turntable for reaction cells or cuvettes
• CPC Class Codes: G01N 35/1079 with means for piercing stoppers or septums
• CPC Class Codes: Y10T 436/11 Automated chemical analysis
• CPC Class Codes: Y10T 436/114998 with treatment or replacement of aspirator element [e.g., cleaning, etc.]
• CPC Class Codes: Y10T 436/119163 with aspirator of claimed structure
• CPC Class Codes: Y10T 436/2575 Volumetric liquid transfer

Abstract

A sample tube entry port for an automatic chemical analyzer supports individual draw tubes that are manually delivered to the analyzer at a sample access station. The entry port facilitates removal of samples by the pipette without exposing operating personnel to accidental contact with liquid materials in the draw tube. To accommodate draw tubes of differing heights, the apparatus includes a stripper that is selectively locked onto an elevationally movable ram carrying a receptacle for receiving a draw tube. A spring-biased tube clamp urges each draw tube against guides within the receptacle to center draw tubes of differing diameters. During operation of the apparatus, the receptacle is first lowered to a predetermined elevation, then raised to an intermediate elevation at which a draw tube closure is properly positioned for placement of the stripper immediately adjacent to its upper surface. The stripper is locked relative to the ram in this elevational relationship, which is maintained as the closure is impaled on the puncture tube and/or the pipette that accesses the contents of the draw tube.

Claims

1. A method for accessing the contents of a draw tube after it has been manually delivered to a sample access station of a chemistry instrument including a probe arm supporting a downwardly-extending open pipette, comprising the following steps:

receiving a manually placed draw tube within an elevationally movable receptacle;

selectively lowering the receptacle and draw tube to a first predetermined elevation;

subsequently raising the receptacle and draw tube to an intermediate elevated position at which an upper surface of a closure in the draw tube is positioned at an second predetermined elevation;

positioning a hollow puncture tube above the closure;

locking a bifurcated stripper relative to the receptacle with the stripper immediately adjacent to the elevation of the upper surface of the closure to match the elevational position of the stripper to the overall height of the draw tube and closure;

raising the receptacle and draw tube to a third predetermined elevation at which the closure is punctured by the puncture tube; and

inserting a pipette through the puncture tube and into the interior of the draw tube to access its contents.

2. The method for accessing the contents of a draw tube as set forth in claim 1, comprising the following additional step prior to the step of selectively lowering the receptacle and draw tube:

selectively urging the draw tube into engagement against upright surfaces at the inside of the receptacle to thereby accommodate draw tubes of differing diameters.

3. The method for accessing the contents of a draw tube as set forth in claim 1, comprising the following additional sequential steps:

first moving the receptacle and locked stripper downwardly until the closure is elevationally clear of the puncture tube; and

then raising the pipette upwardly to elevationally retract it from the closure and puncture tube and free it for subsequent movement.

4. The method for accessing the contents of a draw tube as set forth in claim 1, comprising the following additional sequential steps:

first moving the receptacle and locked stripper downwardly until the closure is elevationally clear of the puncture tube;

then raising the pipette upwardly to elevationally retract it from the closure and puncture tube and free it for subsequent movement;

releasing the bifurcated stripper from the receptacle and moving it to a location clear of the receptacle; and

raising the receptacle and draw tube to an elevation at which the draw tube can be manually removed from within the receptacle.

5. A sample tube entry port for accessing the contents of a draw tube after it has been manually delivered to a sample access station of a chemistry instrument including a probe arm supporting a downwardly-extending open pipette movable about an arcuate path centered about a fixed reference axis, comprising:

tubular puncturing means for temporarily forming an opening through a closure on a manually-delivered draw tube placed in the sample tube entry port means to make the interior of the draw tube accessible by subsequently inserting the pipette of the probe arm means coaxially through the puncturing means;

ram means including an upwardly open receptacle positioned on the chemistry instrument at an elevation below that of the puncturing means for receiving and transversely centering a manually placed draw tube relative to the puncturing means and for elevationally moving the draw tube in directions parallel to the reference axis between a lowered position wherein the draw tube and receptacle are clear of the puncturing means and a raised position wherein the puncturing means forms a temporary opening through a closure at the top of a draw tube within the receptacle in preparation for subsequent coaxial insertion of the pipette; and

a bifurcated stripper including an extension that can be releasably engaged with the ram means to selectively lock the extension to the ram means when the stripper is in its extended position, the extension being pivotally mounted on the chemistry instrument for movement of the stripper between a retracted position clear of the ram means and an extended position overlying the ram means and straddling the axial location of the puncturing means.

6. The sample tube entry port of claim 5, wherein the ram means includes a vertical rack having transverse teeth in meshing engagement with a powered gear;

the extension having a section of gear teeth complementary to the teeth along the rack and adapted to interfit with the teeth so as to selectively lock the extension to the rack means during operation of the sample tube entry port.

7. The sample tube entry port of claim 5, wherein the extension is pivotally mounted by a stationary shaft received within a longitudinal slot formed through the extension, the slot accommodating upward motion of the ram means and stripper when the extension is locked to the ram means.

8. The sample tube entry port of claim 5, further comprising:

control means for selectively lowering the ram means relative to the puncturing means to a first predetermined elevation and subsequently raising the ram means to an elevated position with the upper surface of a closure in a draw tube in the receptacle being at an elevation immediately below that of the bifurcated stripper when in its extended position.

9. The sample tube entry port of claim 5, wherein the upwardly-open receptacle includes upright surfaces adapted to engage draw tubes of differing diameters located within the receptacle;

and

tube clamp means mounted on the receptacle for selectively moves a draw tube into engagement with the upright surfaces.

10. The sample tube entry port of claim 5, wherein the upwardly-open receptacle includes a transverse aperture and upright interior ribs facing the aperture and adapted to engage one side of draw tubes of differing diameters located within the receptacle;

and

a tube clamp mounted on the receptacle selectively projecting through the aperture; and

biasing means operably connected between the receptacle and the tube clamp for moving the tube clamp through the aperture and urging a draw tube into engagement with the upright ribs.

11. The sample tube entry port of claim 5, further comprising:

a cover movably mounted on the chemistry instrument at the sample access station, the cover being movable between an open position clear of the ram means and a closed position overlying it;

the puncturing means being fixed to and extending downwardly from the underside of the cover.

12. The sample tube entry port of claim 5, further comprising:

a cover movably mounted on the chemistry instrument at the sample access station, the cover being movable between an open position clear of the ram means and a closed position overlying it;

the puncturing means being fixed to and extending downwardly from the underside of the cover; and

pivot means interconnecting the cover and the bifurcated stripper for shifting the stripper between its retracted and extended positions in response to movement of the cover between its open and closed positions, respectively.