System and method for rapid vascular drug delivery

• US 5,271,744 A
• Filed: 10/08/1992
• Issued: 12/21/1993
• Est. Priority Date: 04/29/1991
• Status: Expired due to Term

• Current Assignee: Resuscitation Solution, Inc. (Nihon Kohden Corporation)
• Original Assignee: George C. Kramer
• Inventors: Wilson, Jay, Kramer, George C., Thomas, William B.
• Primary Examiner(s): Hirsch, Paul J.
• Application Number:
  US07/958,279
• Time in Patent Office: 439 Days
• Field of Search: 604/49, 604/51, 604/28, 604/135
• US Class Current: 604/506
• CPC Class Codes: A61B 17/3472 for bones, e.g. intraosseus injections
• CPC Class Codes: A61B 2017/00247 Making holes in the wall of the heart, e.g. laser Myocardial revascularization
• CPC Class Codes: A61B 2018/00392 Transmyocardial revascularisation
• CPC Class Codes: A61M 2005/2013 triggering of discharging means by contact of injector with patient body
• CPC Class Codes: A61M 2005/206 With automatic needle insertion
• CPC Class Codes: A61M 2005/3247 Means to impede repositioning of protection sleeve from needle covering to needle uncovering position
• CPC Class Codes: A61M 5/1723 using feedback of body parameters, e.g. blood-sugar, pressure measurement of body parameters A61B5/00
• CPC Class Codes: A61M 5/2033 Spring-loaded one-shot injectors with or without automatic needle insertion multishot dosing syringes A61M5/31525, needle insertion only A61M5/3287
• CPC Class Codes: A61M 5/315 Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
• CPC Class Codes: A61M 5/326 Fully automatic sleeve extension, i.e. in which triggering of the sleeve does not require a deliberate action by the user
• CPC Class Codes: A61M 5/3291 Shafts with additional lateral openings
• CPC Class Codes: A61N 1/0575 with drug delivery

Abstract

A device (10) for rapid vascular drug delivery, particularly through the adult sternum or the pediatric tibia, incorporates a cylindrical syringe body (12), fitted with a needle (14). The syringe body is held in a cylindrical main housing (16) having a front barrel (18) with an orifice (20) through which the needle (14) may be extended. A cylindrical actuation handle (22) fits over end (24) of the main housing (16) for sliding movement along the main housing. A syringe plunger (26) contacts drive plunger (28) and extends into the syringe body (12) from end (30) to confine liquid medication (32) in the syringe body (12). A main spring (34) extends between the drive plunger (28) and the actuation handle (22) to bias the actuation handle (22) in its extended position. A needle return spring (38) extends between the front barrel (18) and the syringe body (12) to bias the needle to its retracted position. The drive plunger (28) has an annular peripheral socket (42) for one or more lock balls (44) which engage one or more openings (45) on the main housing (16) to lock the drive plunger in position with respect to the syringe body (12). A mating annular lock ball trip pocket (46) is positioned on inside surface (48) of the actuation handle to allow the device (10) to be fired when the lock ball(s) in socket (42) reach the pocket (46).

Claims

1. A method for delivering a drug in liquid form to marrow, which comprises positioning a syringe including a needle above a patient'"'"'s skin at a location over a bone containing marrow, releasibly extending said needle from said syringe with sufficient momentum to pass through the patient'"'"'s skin, penetrate the bone and enter said marrow, and discharging the drug in liquid form from the syringe, through the needle and into said marrow.

2. The method for delivering a drug in liquid form to marrow of claim 1 in which said marrow is located in an sternum.

3. The method for delivering a drug in liquid form to marrow of claim 1 in which said marrow is located in a tibia.

4. A method for delivery of a drug in liquid form by injection, which comprises positioning a syringe including a needle in a housing above a patient'"'"'s skin, applying a spring load to said syringe by pressing the housing against the patient, releasing the spring load to extend said needle with velocity sufficient to penetrate bone prior to and during penetration of the patient'"'"'s skin, injecting the drug through the needle, and withdrawing the needle from the patient into the housing.

5. The method for delivery of a drug in liquid form by injection of claim 4, wherein said velocity is sufficient such that a tip of the needle penetrates a bone and enters marrow within the bone.