Amelioration or elimination of postoperative pain

• US 5,272,139 A
• Filed: 05/29/1991
• Issued: 12/21/1993
• Est. Priority Date: 08/27/1986
• Status: Expired due to Term

• Current Assignee: George R. Cary Jr
• Original Assignee: George R. Cary Jr
• Inventors: Cary, George R. Jr.
• Primary Examiner(s): Waddell, Frederick E.
• Assistant Examiner(s): CRIARES, THEODORE J
• Application Number:
  US07/707,309
• Time in Patent Office: 937 Days
• Field of Search: 514/171, 514/178, 514/179, 514/180, 514/177
• US Class Current: 514/171
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/165 having aromatic rings, e.g. colchicine, atenolol, progabide
• CPC Class Codes: A61K 31/215 of carboxylic acids
• CPC Class Codes: A61K 31/57 substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
• CPC Class Codes: A61K 31/66 Phosphorus compounds

Abstract

Following completion of an operative procedure, the topical application of a cortisone preparation into the area of a postoperative wound is useful in ameliorating or eliminating postoperative pain. The postoperative wound can be treated with a local anesthetic agent prior to or during application of the cortisone preparation. The raw surgical surfaces of the wound are doused once with the cortisone preparation, for example, by direct spray with an atomizer or by irrigation with a syringe and needle. The cortisone is not irrigated out with saline following its application. Normal healing takes place.

Claims

1. A method for the reduction or elimination of postoperative pain caused by a postoperative wound, which comprises the surface application by spraying or irrigating the raw surgical surfaces of the wound with a pain reducing amount of a corticosteroid preparation which functions topically to reduce pain, and thereafter closing said wound whereby healing of the wound occurs in a normal manner.

2. The method of claim 1, wherein the corticosteroid preparation is applied to the raw surgical surfaces of the postoperative wound by direct spray using an atomizer.

3. The method of claim 1, wherein the corticosteroid preparation is applied to the raw surgical surfaces of the postoperative wound by irrigation using a syringe and needle.

4. The method of claim 1, which comprises the surface application of less than 3 cc of corticosteroid preparation to the raw surgical surfaces of the postoperative wound.

5. The method of claim 1, wherein the corticosteroid preparation comprises a suspension of betamethasone acetate and beta-methasone sodium phosphate.

6. A method according to claim 1 which further comprises the surface application of an effective amount of a local anesthetic to the surgical surfaces of the postoperative wound for the immediate elimination of pain during the first several hours after the operation.

7. A method according to claim 1 wherein a local anesthetic and corticosteroid are applied to the wound at approximately the same time.

8. A method according to claim 7 wherein a mixture comprising a local anesthetic and corticosteroid is applied to the wound.

9. A method according to claim 1 wherein said corticosteroid preparation contains a local anesthetic.

10. A method according to claim 6 wherein said anesthetic is one of Marcaine, Lidocaine, and Novocain.

11. A method according to claim 6 wherein said anesthetic is applied to the surgical surfaces prior to application of corticosteroid.