Method for dissolving a thickened mass within a living body and dissolving therapeutic apparatus for same

• US 5,273,027 A
• Filed: 09/28/1990
• Issued: 12/28/1993
• Est. Priority Date: 03/27/1990
• Status: Expired due to Term

• Current Assignee: Olympus Optical Company Ltd. (Olympus Corporation)
• Original Assignee: Olympus Optical Company Ltd. (Olympus Corporation)
• Inventors: Ishiwara, Koichiro, Takayama, Shuichi, Noda, Kenji, Uchiyama, Naoki, Iwasaki, Seiji, Tsukagoshi, Tsuyoshi, Sekino, Naomi, Fujio, Koji, Koda, Koji
• Primary Examiner(s): JAWORSKI, FRANCIS J
• Application Number:
  US07/589,945
• Time in Patent Office: 1,187 Days
• Field of Search: 128/DIG. 12, 128/13, 128/27, 128/30, 128/31, 128/24 A, 128/660.03, 604/22, 604/28, 604/48, 604/49-54, 604/65-66, 606/127, 606/128
• US Class Current: 601/54
• CPC Class Codes: A61B 17/22 Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for dilators A61M29/00
• CPC Class Codes: A61B 2017/22082 after introduction of a substance
• CPC Class Codes: A61B 2090/064 for measuring force, pressure or mechanical tension
• CPC Class Codes: A61B 2217/005 with suction drainage system
• CPC Class Codes: A61B 8/4209 by using holders, e.g. positioning frames
• CPC Class Codes: A61B 8/4218 characterised by articulated arms
• CPC Class Codes: A61N 7/00 Ultrasound therapy lithotripsy A61B17/22, A61B17/225; massage using supersonic vibration A61H23/00 ; using ultrasound for introducing media into the body A61M37/0092

Abstract

In the method and dissolving therapeutic apparatus for dissolving a coagulation within a living body, a medicinal liquid for dissolving the coagulation within the living body is injected into the living body, the injected medicinal liquid is left within the living body for a predetermined time and the fluid within the living body containing the coagulation dissolved by the medicinal liquid and the medicinal liquid is substantially all discharged out of the living body. A series of steps including at least respective injecting, leaving and discharging steps is repeated. Preferably, vibrating waves are radiated toward the coagulation during the leaving step.

Claims

1. A method of dissolving a thickened mass within a living body and discharging it out of the living body, comprising the steps of:

injecting into said living body a medicinal liquid for dissolving said thickened mass within said living body;

leaving with said living body for a predetermined time said medicinal liquid injected by said injecting step in order to dissolve said thickened mass with said medicinal liquid;

discharging out of the living body substantially all of the fluid within said living body containing said thickened mass dissolved by said medicinal liquid in said leaving step and said medicinal liquid; and

repeating a series of steps including at least said injecting step, leaving step and discharging step, wherein said medicinal liquid is replaced with fresh medicinal liquid before said medicinal liquid is saturated with said thickened mass.

2. A method according to claim 1 further comprising a step of setting the time for leaving said medicinal liquid within said living body in said leaving step on the basis of dissolving conditions including the size of said thickened mass and the kind of said medicinal liquid.

3. A dissolving therapeutic apparatus for dissolving a thickened mass within a living body, comprising:

an injecting means for injecting into said living body a medicinal liquid for dissolving said thickened mass within said living body;

a sucking means for sucking the fluid within said living body containing said medicinal solution and discharging it out of the living body; and

a controlling means for controlling said injecting means and sucking means so as to make the respective steps of injecting said medicinal liquid into said living body by operating said injecting means, leaving said injecting medicinal liquid within said living body for a predetermined time and discharging out of the living body said fluid within the living body containing said thickened mass dissolved by said left medicinal liquid and said medicinal liquid by operating said sucking means, wherein said medicinal liquid is replaced with fresh medicinal liquid before said medicinal liquid is saturated with said thickened mass.

4. An apparatus according to claim 3 wherein:

said injecting means comprises a liquid tank storing said medicinal liquid not yet used, an injecting conduit means for leading said medicinal liquid within said liquid tank into said living body and an injection pump generating an injection pressure for injecting said medicinal solution into said living body through said injecting conduit means; and

said sucking means comprises a discharged liquid tank storing said discharged fluid, a sucking conduit means for leading said fluid within the living body into said discharged liquid tank and a suction pump generating a suction pressure for sucking said fluid through said sucking conduit means and discharging it into said discharged liquid tank.

5. An apparatus according to claim 4 further comprising a single catheter having said injecting conduit means and said sucking conduit means built-in.

6. An apparatus according to claim 3 wherein said injecting means includes a liquid tank storing said medicinal liquid not yet used, said sucking means includes a discharged liquid tank storing said discharged fluid and said injecting means and sucking means include a single conduit means for leading said medicinal liquid within said liquid tank into said living body and for leading said fluid within the living body into said discharged liquid tank and a single pump alternately generating an injection pressure for injecting said medicinal liquid into said living body through said conduit means and a suction pressure for sucking said fluid through said conduit means and discharging it into said discharged liquid tank.

7. An apparatus according to claim 3 wherein said controlling means includes a setting means for setting the injected amount and sucked amount of said medicinal liquid.

8. An apparatus according to claim 7 wherein the injecting speed of said injecting means is constant and said setting means sets said injected amount by the injecting time by said injecting means.

9. An apparatus according to claim 3 wherein said controlling means includes a setting means for setting the time for leaving said medicinal liquid within said living body on the basis of dissolving conditions including the size of said thickened mass and the kind of said medicinal liquid.

10. An apparatus according to claim 3 wherein said controlling means includes a setting means for setting the number of repetitions of the injection, leaving and suction.

11. An apparatus according to claim 3 wherein said controlling means includes a setting means for setting the respective times for the injection, leaving and suction and the number of repetitions of the injection, leaving and suction and a means for operating all the therapeutic time on the basis of the conditions set by said setting means.

12. An apparatus according to claim 3 further comprising a vibrating wave generating means controlled by said controlling means and generating vibrating waves toward said thickened mass.

13. An apparatus according to claim 12 wherein said controlling means operates said vibrating wave generating means at least in said leaving step.

14. An apparatus according to claim 12 wherein said vibrating wave generating means includes an ultrasonic wave applicator having an ultrasonic vibrator built-in and applied to the body wall.

15. An apparatus according to claim 3 further comprising a pressure detecting means for detecting that the pressure of said medicinal liquid injecting part has become a predetermined upper limit pressure.

16. An apparatus according to claim 15 wherein said controlling means will forcibly stop said injecting means when said pressure detecting means detects that the pressure of said injecting part has become said upper limit pressure in said injecting step.

17. An apparatus according to claim 15 wherein said pressure detecting means includes an offset adjusting means for adjusting the offset of the detected output.

18. An apparatus according to claim 15 wherein said controlling means includes a forcibly operating means for forcibly operating said sucking means when said pressure detecting means detects that the pressure of said injecting part has become said upper limit pressure in said leaving step.

19. An apparatus according to claim 18 wherein said controlling means includes a correcting means for correcting the sucked amount in said sucking step by subtracting the sucked amount part by said forcibly operating means.

20. An apparatus according to claim 15 further comprising a catheter to be arranged at the forward end within the living body and at the base end outside the living body, said injecting means including an injecting path for leading said medicinal liquid into said living body, said sucking means including a sucking path for leading said fluid within said living body into said discharged liquid tank, said catheter having said injecting path and sucking path built-in and said pressure detecting means including a pressure conduit provided within said catheter, opening at one end near said forward end of said catheter and having the other end on the side opposite said one end and a pressure sensor to which said pressure conduit is connected at said other end.

21. An apparatus according to claim 20 wherein said pressure detecting means further includes an adjusting means for adjusting the arranged height of said pressure sensor.

22. An apparatus according to claim 3 wherein said controlling means sucks the same amount of the fluid as the amount of the medicinal liquid injected in said injecting step.

23. An operation setting apparatus to be used for dissolving therapeutic apparatus wherein a medicinal liquid for dissolving a thickened mass within a living body is injected into said living body, said injected medicinal liquid is held within said living body and the fluid within the living body containing said thickened mass dissolved by said medicinal liquid and said medicinal liquid is discharged out of the living body, comprising:

a holding time setting means for optionally setting the time for holding within said living body said medicinal liquid injected into said living body; and

a repeating number setting means for optionally setting the number of repetitions of the three of injecting, holding and discharging steps as one unit, wherein said medicinal liquid is replaced with fresh medicinal liquid before said medicinal liquid is saturated with said thickened mass.

24. An apparatus according to claim 23 further comprising an injecting time setting means for optionally setting the medicinal liquid injecting time to determine the injected amount of the medicinal liquid in said injecting step.

25. An apparatus according to claim 24 wherein said discharging step operating time is automatically set so as to be the same as said medicinal liquid injecting time.

26. An apparatus according to claim 23 further comprising an operating means for operating all the operating time on the basis of the operating manner set by said holding time setting means and said repeating number setting means and a displaying means for displaying the operating result of said operating means.

27. An apparatus according to claim 26 wherein said displaying means displays the elapsing time from the operation starting time to said apparatus together with said all operating time.

28. A dissolving therapeutic apparatus for dissolving a thickened mass within a living body, comprising:

an injecting means for injecting into said living body a medicinal liquid for dissolving said thickened mass within said living body;

a sucking means for sucking the fluid within said living body containing said medicinal liquid and discharging it out of the living body;

a pressure detecting means for detecting the pressure of the injecting part of said medicinal liquid injected by said injecting means;

a controlling means for controlling said injecting means and sucking means;

a setting means operatively connected to said controlling means and for setting in advance the time table of the operations of said injecting means and sucking means; and

said controlling means having a time controlling mode controlling said injecting means and sucking means according to said time table an a pressure controlling mode wherein, when said pressure detecting means detects that the pressure of said injecting part has exceeded a predetermined pressure, apart from the control by said time controlling mode, at least one of said injecting means and sucking means will be controlled and the pressure of said injecting part will be adjusted so that the pressure detected by said pressure detecting means may be below said predetermined pressure, wherein said medicinal liquid is replaced with fresh medicinal liquid before said medicinal liquid is saturated with said thickened mass.

29. An apparatus according to claim 28 wherein said controlling means will return to said time controlling mode when the pressure detected by said pressure detecting means becomes below said predetermined pressure in said pressure controlling mode.

30. An apparatus according to claim 28 wherein said controlling means controls at least one of said injecting means and sucking means by changing said time table in said pressure controlling mode.

31. An apparatus according to claim 30 wherein said controlling means, in said time controlling mode, repeats as one unit the three of the injecting step by said injecting means, the leaving step of leaving within said living body said injected medicinal liquid and the sucking step by said sucking means and, in said pressure controlling mode, changes said time table in said one unit.

32. An apparatus according to claim 31 wherein said time table is changed without changing all time of said one unit.

33. An apparatus according to claim 28 wherein said pressure controlling mode includes that, in case the pressure detected by said pressure detecting means exceeds said predetermined pressure during the operation of said injecting means in said time controlling mode, even within the injecting time set by said setting means, the injecting operation will be stopped and the next sucking time will be changed to be the same time as the injecting time until the injecting operation is stopped.

34. An apparatus according to claim 28 wherein said controlling means includes that, in said time controlling mode, the three of the injecting step by said injecting means, the leaving step of leaving within said living body said injected medicinal liquid and the sucking step by said sucking means are repeated in a time set in advance and, in said pressure controlling mode, in case the pressure detected by said pressure detecting means exceeds said predetermined pressure in said leaving step, even within the set leaving time, said sucking means will be urgently operated so that said detected pressure may be below said predetermined pressure, the sucked amount by said urgent operation will be determined and the sucking time in the next sucking step will be changed to be the time obtained by subtracting the time corresponding to said sucked amount by said urgent operation from the set sucking time.

35. A dissolving therapeutic apparatus for dissolving a coagulation within a living body, comprising:

a catheter for injecting into said living body a medicinal liquid for dissolving said coagulation within said living body, sucking the fluid within said living body containing said medicinal liquid and discharging said fluid out of the living body;

a vibrating wave observing apparatus for observing the ultrasonic wave image of the observed part within said living body;

a vibrating wave generating apparatus for applying vibrating waves to accelerate the dissolution of the coagulation to the treated part within said living body; and

a supporting apparatus for supporting said ultrasonic wave observing apparatus and vibrating wave generating apparatus, said supporting apparatus including a moving means for moving said observing apparatus and vibrating wave generating apparatus so as to selectively arrange said observing part of said observing apparatus and said treating part of said vibrating wave generating apparatus in any desired part of said living body.

36. An apparatus according to claim 35 wherein said supporting apparatus further includes a supporting member fixing said observing apparatus and said vibrating wave generating apparatus and rotatable with the position at equal distances from the fixing position of said observing apparatus and the fixing position of said vibrating wave generating apparatus as a center and said moving means is to rotate said supporting member.

37. A dissolving therapeutic apparatus for dissolving a thickened mass within a living body, comprising:

an injecting means for injecting into said living body a medicinal liquid for dissolving said thickened mass within said living body;

a sucking means for sucking the fluid within said living body containing said medicinal liquid and discharging said fluid out of the living body; and

a controlling means for controlling said injecting means and sucking means so as to make an injecting step of injecting said medicinal liquid into said living body by operating said injecting means and a sucking step of discharging out of the living body said fluid within the living body containing said coagulation dissolved by said medicinal liquid and said medicinal liquid by operating said sucking means;

said controlling means controlling said injecting means and sucking means so as to provide a medicinal liquid movement pausing period for radiating vibrating waves toward said thickened mass between said injecting step and sucking step, wherein said medicinal liquid is replaced with fresh medicinal liquid before said medicinal liquid is saturated with said thickened mass.

38. An apparatus according to claim 37 which is an apparatus for dissolving a gallstone as said coagulation and in which said medicinal liquid is to dissolve said gallstone.

39. A dissolving therapeutic apparatus for dissolving a gallstone within a gallbladder, comprising:

an injecting means for injecting into said gallbladder a medicinal liquid for dissolving said gallstone within said gallbladder;

a sucking means for sucking the fluid within said gallbladder containing said medicinal liquid and discharging said fluid; and

a controlling means for controlling said injecting means and sucking means so as to repeat as one unit at least three steps including an injecting step of injecting said medicinal liquid into said gallbladder by operating said injecting means, a leaving step of leaving said medicinal liquid within said gallbladder by stopping the operation of said injecting means and making the operation of dissolving said gallstone with said left medicinal liquid and a sucking step of discharging out of the gallbladder the fluid within said gallbladder containing said medicinal liquid having ended said dissolving operation by operating said sucking means;

said controlling means controlling said injecting means and sucking means so as to provide a pausing step for sucking the increased part of said fluid by the gall having flowed into said gallbladder, as required, by operating said sucking means after said sucking step, wherein said medicinal liquid is replaced with fresh medicinal liquid before said medicinal liquid is saturated with said thickened mass.

40. An apparatus according to claim 39 further comprising a pressure detecting means for detecting the pressure within said gallbladder, said controlling means operating said sucking means in response to the detected output of said pressure detecting means in said pausing step.

41. An apparatus according to claim 39 wherein said controlling means provides said pausing step at intervals of several repetitions of said unit.