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Capillary array confocal fluorescence scanner and method

  • US 5,274,240 A
  • Filed: 02/24/1992
  • Issued: 12/28/1993
  • Est. Priority Date: 01/12/1990
  • Status: Expired due to Term
First Claim
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1. A scanner for exciting and detecting radiation from a plurality of adjacent capillary passages comprisinga plurality of side-by-side capillary passages disposed in a plane,a source of radiant energy of a first wavelength,an objective lens for receiving and focusing said radiant energy at an excitation volume in the plane of said plurality of side-by-side capillary passages,means for moving said plurality of side-by-side capillary passages so that said excitation volume sequentially and repetitively is within one of said plurality of side-by-side capillary passages to excite material in said one passage and cause the material to radiate energy at a different wavelength,said objective lens serving to collect the radiated energy of said different wavelength and direct it to an optical system which includes confocal spatial and spectral filter means to transmit said radiated energy at said different wavelength and reject radiation at other wavelengths,a detection system for receiving said radiated energy and generating a signal, andcomputer means for receiving and processing said signal to provide an output representative of the material at the excitation volume in each of said plurality of side-by-side capillary passages.

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