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Stable suspension formulations of bioerodible polymer matrix microparticles incorporating drug loaded ion exchange resin particles

  • US 5,275,820 A
  • Filed: 12/27/1990
  • Issued: 01/04/1994
  • Est. Priority Date: 12/27/1990
  • Status: Expired due to Fees
First Claim
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1. A sustained release pharmaceutical compound delivery composition having improved delivery characteristics and enhance long-term storage stability, said composition comprising:

  • a non-ionic liquid suspension of microparticulates, said microparticulates formed of an erodible bioadhesive polymeric matrix of poly and polyvinylpyrrolidone wherein the ratio of poly (methylvinylether/maleic anhydride) to polyvinylpyrrolidone ranges from approximately 1;

    1 to 4;

    1 by weight, incorporating at least one ion exchange resin particle sized from approximately 1 μ

    m to 100 μ

    m, said ion exchange resin particle having approximately 2 to 50 wt % of a pharmaceutical compound releasably bound thereto.

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