Extracorporeal lung assistance apparatus and process

• US 5,277,176 A
• Filed: 06/29/1992
• Issued: 01/11/1994
• Est. Priority Date: 06/29/1992
• Status: Expired due to Fees

• Current Assignee: Howard N. Reynolds, Nader M. Habashi, Ulf R. Borg
• Original Assignee: Howard N. Reynolds, Nader M. Habashi, Ulf R. Borg
• Inventors: Borg, Ulf R., Habashi, Nader M., Reynolds, Howard N.
• Primary Examiner(s): Burr, Edgar S.
• Assistant Examiner(s): Lewis, Aaron J.
• Application Number:
  US07/905,347
• Time in Patent Office: 561 Days
• Field of Search: 128/200.24, 128/202.16, 128/205.12, 128/913, 128/DIG. 3, 261/104, 261/DIG. 28, 422/44, 422/45, 422/48
• US Class Current: 128/200.24
• CPC Class Codes: A61M 1/1698 Blood oxygenators with or without heat-exchangers intracorporal A61M1/1678; manufacturing of membranes therefor B01D67/00; semi-permeable membranes for separation processes characterised by their properties B01D69/00; semi-permeable membranes characterised by their material B01D71/00
• CPC Class Codes: A61M 2202/0476 Oxygenated solutions
• CPC Class Codes: Y10S 128/03 Heart-lung
• CPC Class Codes: Y10S 128/913 Breathable liquids

Abstract

An extracorporeal lung assistance device having an oxygen-containing gas chamber positioned in such relationship to a gas exchange chamber that transfer of oxygen to blood and the withdrawal of carbon dioxide from blood disposed may be made. The gas exchange chamber has a blood flow channel extending through the gas exchanger defined by a microporous membrane forming a wall separating the blood flow channel from an oxygen, carbon dioxide exchange media. A second membrane supported in spaced-apart relationship from said first membrane. The space between the membranes is filled with the oxygen carbon dioxide exchange media.

Claims

1. An extracorporeal lung assistance device comprising:

a housing having at least one oxygen-containing gas chamber, and a gas exchange member adjacent said oxygen-containing gas chamber;

said oxygen-containing gas chamber having an oxygen-rich gas inlet and an oxygen-poor gas outlet;

said gas exchange member comprising a blood flow channel extending through said gas exchange member having blood inlet and blood outlet means in fluid communication with the exterior of said housing for communication to a circulatory system,

said gas exchange member having an outer microporous membrane defining a wall between the oxygen containing gas chamber and the gas exchange member, an inner microporous membrane defining a wall between the gas exchange member and the blood flow channel, said membranes being supported in spaced apart relationship by end support means, and the space between said outer microporous membrane and said inner microporous membrane containing an oxygen and carbon dioxide transfer media whereby the carbon dioxide in the oxygen-poor blood is exchanged for oxygen as the oxygen-blood passes through the gas exchange member.

2. The extracorporeal lung assistance device according to claim 1 including means connecting the oxygen-rich inlet to an oxygen-rich supply and the oxygen poor outlet to a gas collection means.

3. The extracorporeal lung assistance device according to claim 1 including mean connecting the blood inlet and outlet to the circulatory system of a patient.

4. The extracorporeal lung assistance device according to claim 1 wherein at least one of said membranes is an acrylonitrile and sodium methallyl sulfonate copolymer.

5. The extracorporeal lung assistance device according to claim 1 wherein at least one of said membranes is selected from the group consisting of microporous polypropylene, silicone, microporous polytetrafluoroethylene, polysulfone, and polyamide membranes.

7. The extracorporeal lung assistance device according to claim 1 wherein the ratio of the surface area of the membrane defining the wall between the oxygen containing gas chamber and the gas exchange member to the surface area of the other membrane is greater than 1.

9. The extracorporeal lung assistance device according to claim 1 wherein said housing is a generally circular configuration and said gas exchange member is disposed within said housing in such manner that said oxygen-containing gas chamber surrounds said gas exchange member in spaced-apart relationship.

10. The extracorporeal lung assistance device according to claim 1 wherein said housing is a generally flat configuration and said gas exchange member is generally flat in configuration and disposed within said housing in such a manner that said oxygen containing gas chamber is adjacent to said gas exchange member on at least two sides in spaced-apart relationship.

6. The extracorporeal lung assistance device according to claim I wherein said oxygen and carbon dioxide transfer media is a perfluorocarbon.

8. The extracorporeal lung assistance device according to claim 6 wherein the ratio of the surface area of the membrane defining the wall between the oxygen containing gas chamber and the gas exchange member to the surface area of the other membrane is from about 1.25:

1.00 to about 3.0;

1.0.

11. A method for treating blood comprising:

(a) providing a source of oxygen containing gas;

(b) providing a housing having at least one oxygen containing gas chamber and a gas exchange member including a first microporous membrane adjacent said gas chamber;

(c) providing a blood flow channel having a blood inlet and a blood outlet extending through said gas exchange member;

(d) providing a second microporous membrane as a wall between said gas exchange chamber and said first microporous membrane in spaced relationship to the first microporous membrane while supporting said microporous membrane using end support means;

(e) providing an oxygen and carbon dioxide transfer media between said microporous membranes;

(f) passing said oxygen containing gas in contact with said first microporous membrane and simultaneously passing oxygen-poor blood in contact with said second microporous membrane, whereby carbon dioxide within the oxygen-poor blood is exchanged for oxygen across said microporous membranes and said transfer media.

12. The method for treating blood according to claim 11 wherein at least one of said membranes is an acrylonitrile and sodium methallyl sulfonate copolymer.

13. The method of treating blood according to claim 11 wherein at least one of said membranes is selected from the group consisting of microporous polypropylene, silicone, microporous polytetrafluoroethylene, polysulfone, and polyamide membranes.

14. The method for treating blood according to claim 11 wherein said oxygen and carbon dioxide transfer media is a perfluorocarbon.