Noninvasive measurement of hematocrit and hemoglobin content by differential optical analysis
First Claim
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1. A noninvasive method of generating a ratio of signals from which measurement of one or more blood parameters in living tissue may be made, comprising the steps of:
- a) illuminating the tissue with light of a first wavelength λ
1 at an incident tissue site, such that the light is scattered and absorbed by the tissue;
b) while the volume of blood in the tissue is changing, detecting the scattered light at two separate detection tissue sites remote from said incident site and generating first and second electrical signals proportional to the intensity of the detected light;
c) normalizing the first and second electrical signals to produce first and second normalized signals; and
d) forming a ratio of the first and second normalized signals.
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Abstract
The present invention relates to the noninvasive measurement of blood hematocrit and hemoglobin content using differential optical absorption of two or more wavelengths of light during blood volume changes. The method is also useful for noninvasive measurements of other blood analytes, such as glucose, where variations in hematocrit or blood hemoglobin concentration cause errors in the measurement.
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Citations
12 Claims
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1. A noninvasive method of generating a ratio of signals from which measurement of one or more blood parameters in living tissue may be made, comprising the steps of:
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a) illuminating the tissue with light of a first wavelength λ
1 at an incident tissue site, such that the light is scattered and absorbed by the tissue;b) while the volume of blood in the tissue is changing, detecting the scattered light at two separate detection tissue sites remote from said incident site and generating first and second electrical signals proportional to the intensity of the detected light; c) normalizing the first and second electrical signals to produce first and second normalized signals; and d) forming a ratio of the first and second normalized signals. - View Dependent Claims (2, 3, 4)
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5. A method of noninvasive measurement of predetermined blood constituents in living tissue comprising the steps of:
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a) illuminating the tissue with light of a first wavelength λ
1 at an incident tissue site S1, such that the light is scattered and absorbed in the tissue;b) while the volume of blood in the tissue is changing, detecting the illuminated light, after it is scattered and absorbed at two separate tissue sites remote from the incident site and generating first and second electrical signals proportional thereto; c) separating a respective DC component of the first and second electrical signals from a respective AC component of the first and second electrical signals; d) dividing the AC component of the respective first and second electrical signals by the DC component of the first and second electrical signals to produce a respective normalized first and second electrical signals; e) forming a ratio by dividing the normalized first signal by the normalized second signal; and f) comparing said ratio with a predetermined value to determine the relative concentration of a predetermined blood constituent in the tissue. - View Dependent Claims (6, 7, 8, 9)
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10. Apparatus for noninvasive generation of a ratio signal for measurement of blood parameters in living tissue comprising:
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a) a light source for illuminating the tissue with light of a first wavelength λ
1 at an incident tissue site, such that the light is scattered and absorbed by the tissue;b) light detectors for detecting the scattered light from λ
1 at two separate detection tissue sites remote from said incident site and generating first and second electrical signals proportional to the intensity of the detected light;c) normalizing means for normalizing the first and second electrical signals to produce first and second normalized signals; and d) ratio means for forming a ratio of the first and second normalized signals. - View Dependent Claims (11, 12)
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Specification