Coronory artery imaging method and apparatus

• US 5,277,182 A
• Filed: 06/24/1991
• Issued: 01/11/1994
• Est. Priority Date: 03/14/1988
• Status: Expired due to Term

• Current Assignee: Hitachi Medical Corporation (Hitachi, Ltd.)
• Original Assignee: Hitachi, Ltd.
• Inventors: Kohno, Hideki, Miyamoto, Yoshiyuki, Sano, Koichi, Koizumi, Hideaki, Yokoyama, Tetsuo, Takeda, Ryuzaburo
• Primary Examiner(s): Smith, Ruth S.
• Application Number:
  US07/723,692
• Time in Patent Office: 932 Days
• Field of Search: 128/653.2, 128/653.3, 128/708, 324/306, 324/309
• US Class Current: 600/413
• CPC Class Codes: A61B 5/055 involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
• CPC Class Codes: G01R 33/563 of moving material, e.g. flow contrast angiography

Abstract

A method for imaging the coronary artery of a living body using nuclear magnetic resonance, wherein a patient is located in a static magneic field and the heart cycle of the patient is detected with the heart dilation period of the patient being determined in accordance with the detected heart cycle. Then, the coronary artery of the patient is portrayed on the nuclear magnetic resonance signal generated by applying high-frequency energy to the patient during the determined heart dilation period.

Claims

1. A method for enabling imaging of a coronary artery of a living body using nuclear magnetic resonance, comprising the steps of:

locating the living body in a magnetic field;

detecting a cardiac cycle of the living body;

determining a dilation phase of a heart of the living body on the basis of the detected cardiac cycle; and

selectively generating a nuclear magnetic resonance signal for enabling imaging of the coronary artery during the determined dilation phase.

2. A method according to claim 1, wherein the cardiac cycle of the living body is detected by an electrocardiograph.

3. A method according to claim 1, wherein the step of determining a dilation phase includes determining when a difference between blood velocity in the coronary artery and blood velocity in a left ventricle of the heart is at a maximum.

4. A method according to claim 1, further comprising the step of imaging the coronary artery.

5. A method according to claim 1, wherein the step of selectively generating a nuclear magnetic resonance signal for enabling imaging of the coronary artery includes applying high frequency energy to the living body in the presence of a magnetic field gradient flow encoding pulse to obtain a first nuclear magnetic resonance signal sensitive to blood flow in the coronary artery when blood flow in a main artery is substantially stationary and applying high-frequency energy to the living body in the presence of a magnetic field gradient flow canceling pulse to obtain a second nuclear magnetic resonance signal which is insensitive to blood flow in the coronary artery and main artery, and obtaining a difference signal of the first and second nuclear magnetic resonance signals as the nuclear magnetic resonance signal for enabling imaging of the coronary artery.

6. A method for enabling imaging of a coronary artery of a living body using nuclear magnetic resonance, comprising the steps of:

locating the living body in a static magnetic field;

detecting a cardiac cycle of the living body;

determining a dilation phase of a heart of the living body on the basis of the detected cardiac cycle;

generating first and second nuclear magnetic resonance signals during the determined dilation phase, the first nuclear magnetic resonance signal having a component depending on blood flow in the coronary artery, the component being substantially absent from the second nuclear magnetic resonance signal; and

determining a difference between the first and second nuclear magnetic resonance signals for obtaining a signal for enabling imaging of the coronary artery.

7. A method according to claim 6, wherein the component is one of phase, direction, velocity, acceleration, eddy flow, laminar flow, and flow rate of the blood flow in the coronary artery.

8. A method according to claim 6, wherein the cardiac cycle of the living body is detected by an electrocardiograph.

9. A method according to claim 6, wherein the step of determining a dilation phase includes determining when a difference between blood velocity in the coronary artery and blood velocity in a left ventricle of the heart is at a maximum.

10. A method according to claim 6, further comprising the step of imaging the coronary artery.

11. An apparatus for enabling imaging of a coronary artery of a living body using nuclear magnetic resonance, comprising:

means for generating a static magnetic field;

means for applying a magnetic field gradient to the living body in the presence of the static magnetic field;

means for generating high-frequency energy;

means for detecting a cardiac cycle of the living body;

means responsive to the cardiac cycle detecting means for determining a dilation phase of a heart of the living body on the basis of the detected cardiac cycle; and

means for applying the high-frequency energy to the living body in the presence of the magnetic field gradient during the determined dilation phase so as to selectively generate a nuclear magnetic resonance signal for enabling imaging of the coronary artery.

12. An apparatus according to claim 11, wherein the cardiac cycle detecting means comprises an electrocardiograph.

13. An apparatus according to claim 11, wherein the means for determining a dilation phase further determines when a difference between blood velocity in the coronary artery and blood velocity in a left ventricle of the heart is at a maximum.

14. An apparatus according to claim 11, further comprising means for imaging the coronary artery.

15. An apparatus according to claim 11, wherein the means for applying the high-frequency energy applies the high-frequency energy to the living body in the presence of a magnetic field gradient flow encoding pulse to obtain a first nuclear magnetic resonance signal sensitive to blood flow in the coronary artery when blood flow in a main artery is substantially stationary and applies the high-frequency energy to the living body in the presence of a magnetic field gradient flow canceling pulse to obtain a second nuclear magnetic resonance signal which is insensitive to blood flow in the coronary artery and main artery, and obtains a difference signal of the first and second nuclear magnetic resonance signals as the nuclear magnetic resonance signal for enabling imaging of the coronary artery.

16. An apparatus for enabling a coronary artery of a living body using nuclear magnetic resonance, comprising:

means for generating a static magnetic field;

means for applying a magnetic field gradient to the living body in the presence of the static magnetic field;

means for generating high-frequency energy;

means for detecting a cardiac cycle of the living body;

means responsive to the cardiac cycle detecting means for determining a dilation phase of a heart of the living body on the basis oft he detected cardiac cycle;

means for applying the high-frequency energy to the living body in the presence of the magnetic field gradient during the determined dilation phase so as to generate first and second nuclear magnetic resonance signals, the first nuclear magnetic resonance signal having a component depending on blood flow in the coronary artery, the component being substantially absent from the second nuclear magnetic resonance signal; and

means for determining a difference between the first and second nuclear magnetic resonance signals so as to obtain a signal for enabling imaging of the coronary artery.

17. An apparatus according to claim 16, wherein the component is one of phase, direction, velocity, acceleration, eddy flow, laminar flow, and flow rate of the blood flow in the coronary artery.

18. An apparatus according to claim 16, wherein the cardiac cycle detecting means comprises an electrocardiograph.

19. An apparatus according to claim 16, wherein the means for determining a dilation phase further determines when a difference between blood velocity in the coronary artery and blood velocity in a left ventricle of the heart is at a maximum.

20. An apparatus according to claim 16, further comprising means for imaging the coronary artery.