Device and method for extracorporeal blood treatment
First Claim
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1. A method for extracorporeal treatment of blood to effectively and consistently remove toxins therefrom over an extended period of time, comprising:
- passing the blood through a blood side of a plate dialyzer having a blood inlet to and a blood outlet from a blood side separated from a dialysate side by dialyzer membranes, said plate dialyzer further having a dialysate inlet to and dialysate outlet from said dialysate side, said dialyzer membranes being compliantly formed to expand and compress in response to alternating negative pressure and positive pressure on said dialysate side of said dialyzer; and
passing a sorbent suspension through said dialysate side so as to dialyze toxins in the blood across the membranes;
wherein said passing steps are caused by the application of alternating negative and positive pressure on said dialysate side so as to expand and contract said membranes and agitate the sorbent suspension to prevent settling and maintain chemical gradients across the membrane, while also maintaining a positive pressure gradient from said blood side to said dialysate side; and
wherein said alternating negative and positive pressure are caused by an accumulator reservoir connected to said dialysate side and operable to alternatively accumulate and expel dialysate.
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Abstract
Disclosed are preferred devices and methods which provide extracorporeal treatment of blood to effectively and consistently remove toxins therefrom and from patients over extended periods of time.
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Citations
21 Claims
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1. A method for extracorporeal treatment of blood to effectively and consistently remove toxins therefrom over an extended period of time, comprising:
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passing the blood through a blood side of a plate dialyzer having a blood inlet to and a blood outlet from a blood side separated from a dialysate side by dialyzer membranes, said plate dialyzer further having a dialysate inlet to and dialysate outlet from said dialysate side, said dialyzer membranes being compliantly formed to expand and compress in response to alternating negative pressure and positive pressure on said dialysate side of said dialyzer; and passing a sorbent suspension through said dialysate side so as to dialyze toxins in the blood across the membranes; wherein said passing steps are caused by the application of alternating negative and positive pressure on said dialysate side so as to expand and contract said membranes and agitate the sorbent suspension to prevent settling and maintain chemical gradients across the membrane, while also maintaining a positive pressure gradient from said blood side to said dialysate side; and wherein said alternating negative and positive pressure are caused by an accumulator reservoir connected to said dialysate side and operable to alternatively accumulate and expel dialysate. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
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14. A dialysis instrument, comprising:
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a plate dialyzer having a blood inlet to and a blood outlet from a blood side separated from a dialysate side by dialyzer membranes, said plate dialyzer further having a dialysate inlet to and dialysate outlet from said dialysate side, said dialyzer membranes being compliantly formed to expand and compress in response to alternating negative pressure and positive pressure on said dialysate side of said dialyzer; dialysate circulating means for circulating dialysate through said dialysate side of said dialyzer in a direction generally from said dialysate inlet to said dialysate outlet; said dialysate circulating means including an accumulator reservoir operable to alternately accumulate and expel dialysate to apply alternating negative pressure and positive pressure on said dialysate side of said dialyzer and to thereby cause said expansion and contraction of dialyzer membranes while maintaining a positive pressure gradient from said blood side to said dialysate side of said dialyzer; blood circulating means for circulating blood through said blood side of said dialyzer in a direction generally from said blood inlet to said blood outlet and powered by said expansion and contraction of dialyzer membranes caused by alternating negative and positive pressure on said dialysate side of said dialyzer. - View Dependent Claims (15, 16, 17, 18, 19, 20, 21)
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Specification