Thromboresistant material and articles
First Claim
1. A thromboresistant article for use in contact with blood or blood products, the article comprising at least one exposed surface for contacting blood or blood products, the surface having thereon an antithrombotic agent comprised of a copolymer of AA and AMPS in which the relative amounts of AA and AMPS in the copolymer are predetermined to provide SO3 groups and COO-- groups in a ratio comparable to the antithrombogenic binding sequence of heparin.
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Accused Products
Abstract
Biocompatible heparin-like material and surfaces thereof are made by co-polymerization of acrylic acid (AA) and 2-acrylamido-2-methyl propane sulfonic acid (AMPS) and attaching the copolymer to a suitable substrate or blending the copolymer into a suitable substrate. The material produced also possesses surface slip-properties and some decreased bacterial and platelet adherence.
113 Citations
18 Claims
- 1. A thromboresistant article for use in contact with blood or blood products, the article comprising at least one exposed surface for contacting blood or blood products, the surface having thereon an antithrombotic agent comprised of a copolymer of AA and AMPS in which the relative amounts of AA and AMPS in the copolymer are predetermined to provide SO3 groups and COO-- groups in a ratio comparable to the antithrombogenic binding sequence of heparin.
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10. A method for providing thromboresistance to the polymeric, blood-contacting surface of an article comprising the steps of:
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(a) making an aqueous monomer solution of AAm and AMPS in a ratio to provide SO3 -- groups and COO-- groups comparable to the antithrombogenic binding sequence of heparin; (b) adding ceric ion to the aqueous monomer solution; (c) reacting the blood-contacting surface of the article with the ceric ion-containing monomer solution to produce a grafted copolymer; and (d) hydrolyzing the grafted copolymer to convert the AAm to AA. - View Dependent Claims (11, 12)
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13. A method for providing thromboresistance in a polymeric material comprising the steps of:
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(a) making an aqueous monomer solution of AA and AMPS in a ratio to provide SO3 -- groups and COO-- groups comparable to the antithrombogenic binding sequence of heparin; (b) polymerizing the monomer solution into a copolymer gel; (c) drying the copolymer gel; and (d) blending the dried gel with the polymeric material. - View Dependent Claims (14, 15, 16)
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17. A method for providing thromboresistance to the blood-contacting surface of an article comprising the steps of:
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(a) making an aqueous monomer solution of AA and AMPS in a ratio to provide SO3 -- groups and COO-- groups comparable to the antithrombogenic binding sequence of heparin; (b) polymerizing the monomer solution into a copolymer gel; (c) drying the copolymer gel; (d) dissolving the dried gel in a solvent; (e) coating the dissolved gel onto the blood-contacting surface; and (f) drying the coating. - View Dependent Claims (18)
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Specification