Liquid control system for diagnostic cartridges used in analytical instruments

• US 5,279,791 A
• Filed: 01/19/1993
• Issued: 01/18/1994
• Est. Priority Date: 03/04/1991
• Status: Expired due to Term

• Current Assignee: Roche Diagnostics Operations Incorporated (Roche Holding AG)
• Original Assignee: Biotrack, Inc. (Novartis Ag)
• Inventors: Aldrich, William, Gratiot, Daniel
• Primary Examiner(s): Housel, James C.
• Assistant Examiner(s): Soderquist, Arlen
• Application Number:
  US08/006,664
• Time in Patent Office: 364 Days
• Field of Search: 422/58, 422/99, 422/100, 422/102
• US Class Current: 422/404
• CPC Class Codes: B01L 2200/027 for microfluidic devices
• CPC Class Codes: B01L 2200/141 Preventing contamination, tampering
• CPC Class Codes: B01L 2300/0809 rectangular shaped
• CPC Class Codes: B01L 2400/0406 capillary forces
• CPC Class Codes: B01L 3/502715 characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
• CPC Class Codes: B01L 9/527 for microfluidic devices, e.g. used for lab-on-a-chip
• CPC Class Codes: G01N 1/38 Diluting, dispersing or mixing samples
• CPC Class Codes: G01N 2035/00277 Special precautions to avoid contamination (e.g. enclosures, glove- boxes, sealed sample carriers, disposal of contaminated material)

Abstract

A liquid control system for a diagnostic cartridge that is insertable into an analytical instrument, which has a liquid control region located at a border between interior and exterior surfaces of the cartridge when the cartridge is inserted into a slot in the analytical instrument, wherein the region is adapted to fit with an edge formed by exterior surfaces of the analytical instrument and the slot, thereby providing a capillary gap at the edge having a gap width smaller than any gap width of any space contiguous to the gap in the interior of the slot when the cartridge is inserted in the instrument.

Claims

1. A liquid control system for preventing fluid from entering within an analytical instrument, wherein said system comprises:

in combination

a diagnostic cartridge that accepts liquid samples;

an analytical instrument having a slot for insertion of a portion of said diagnostic cartridge within said analytical instrument;

a ridge projecting outward from at least one face of said diagnostic cartridge; and

a first surface located at an edge formed by exterior surfaces of said analytical instrument and interior surfaces of said slot wherein first and second gaps are formed when said diagnostic cartridge is inserted in said slot, said first gap being formed between said ridge and said first surface and having a capillary gap width, said second gap being formed contiguous to said first gap within the analytical instrument between said diagnostic cartridge and said interior surfaces of said slot and having a gap width which is larger than any adjacent capillary gap width of said first gap, and wherein said first gap is absent in a region beneath said diagnostic cartridge to allow fluid collected in said first gap to drain.

2. The liquid control system of claim 1, wherein said first surface is formed as a depression at said edge of said slot.

3. The liquid control system of claim 2, wherein said ridge has an interior portion facing said depression and an exterior portion facing away from said depression so that an exterior surface of said instrument and said exterior portion of said ridge together form a planar surface.

4. The liquid control system of claim 1, wherein said ridge continuously projects outward from all surfaces of the diagnostic cartridge adjacent to said edge except a bottom surface.

5. The liquid control system of claim 1, wherein said second gap has a non-capillary gap width.

6. A liquid control system for preventing fluid from entering within an analytical instrument, wherein said system comprises:

in combination

a diagnostic cartridge that accepts liquid samples;

an analytical instrument having a slot for insertion of a portion of said diagnostic cartridge within said analytical instrument;

a depression in at least one face of said diagnostic cartridge; and

a first surface located at an edge formed by exterior surfaces of said analytical instrument and interior surfaces of said slot wherein first and second gaps are formed when said diagnostic cartridge is inserted in said slot, said first gap being formed between said depression and said first surface and having a capillary gap width, said second gap being formed contiguous to said first gap within the analytical instrument between said diagnostic cartridge and said interior surfaces of said slot and having a gap width which is larger than any adjacent capillary gap width of said first gap, and wherein said first gap is absent in a region beneath said diagnostic cartridge to allow fluid collected in said first gap to drain.

7. The liquid control system of claim 6, wherein said second gap has a non-capillary gap width.