Sensitive diagnostic test for lyme disease
First Claim
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1. An isolated DNA segment consisting of the DNA sequence ##STR1## which hybridizes with DNA of Borrelia burgdorferi origin, and which does not cross hybridize with other Borrelia species.
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Abstract
The nucleotide sequence of a recombinant clone containing a specific segment of Borrelia burgdorferi DNA which enables the identification of the spirochetes causing Lyme disease has been provided. A diagnostic kit containing oligonucleotide primers derived from this sequence, suitable for the detection of Borrelia burgdoferi in a PCR assay, as well as the cloned DNA of the present invention, allows the detection of Lyme disease with sensitivity and specificity not heretofore attained by any other test.
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6 Claims
- 1. An isolated DNA segment consisting of the DNA sequence ##STR1## which hybridizes with DNA of Borrelia burgdorferi origin, and which does not cross hybridize with other Borrelia species.
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