Process for analyzing samples for ion analysis

• US 5,279,972 A
• Filed: 01/28/1992
• Issued: 01/18/1994
• Est. Priority Date: 09/26/1988
• Status: Expired due to Fees

• Current Assignee: Waters Technologies Corporation (Waters Corporation)
• Original Assignee: Millipore Corporation
• Inventors: Jones, William, Lawrence, Robert III, Heckenberg, Allan L., Jandik, Peter P.
• Primary Examiner(s): Housel, James C.
• Assistant Examiner(s): Cano, Milton I.
• Application Number:
  US07/827,190
• Time in Patent Office: 721 Days
• Field of Search: 210/500.23, 210/500.27, 210/500.37, 210/638, 210/641, 210/650, 210/653, 210/656, 210/678, 210/686, 436/79, 436/177, 436/178, 436/161, 422/70
• US Class Current: 436/178
• CPC Class Codes: B01D 15/36 involving ionic interaction
• CPC Class Codes: G01N 1/405 by adsorption or absorption
• CPC Class Codes: G01N 30/02 Column chromatography
• CPC Class Codes: G01N 30/14 by elimination of some components
• CPC Class Codes: G01N 33/18 Water
• CPC Class Codes: Y10T 436/25375 Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.]
• CPC Class Codes: Y10T 436/255 including use of a solid sorbent, semipermeable membrane, or liquid extraction

Abstract

A sample preparation process and apparatus are provided for samples to be analyzed subsequently, such as by liquid chromatography. The sample is passed in contact with an ion exchange polymer which is characterized by being capable of facilitating removal of one or more undesired ions from the sample to be replaced with an ion transferred from the bound exchange site of the polymer and through the polymer. The polymer is prewashed with water to remove substantially all leachable species from the polymer. In one embodiment, the polymer is coated with a color indicator capable of changing color when the polymer is depleted of the ion to be transferred therefrom. The ion exchange capacity of the apparatus can be significantly expanded by using a counter ion donating solution capable of replacing the bound ions at the ion exchange sites as they become exchanged for the undesired ions from the sample.

Claims

1. The process for analyzing a sample containing ion species in a solution which comprises:

washing a membrane or hollow fiber formed from an ion exchange polymer to remove substantially all water leachable species from said polymer and to form a washed ion exchange polymer,

said washed ion exchange polymer being capable of exchanging a bound cation for a cation in solution while substantially avoiding the introduction of water-leachable species in solution,

passing said sample into contact with said washed ion exchange polymer,

said washed ion exchange polymer being immersed in a counter ion donating solution for donating cations comprising said bound cations while avoiding contact of said sample with said counter ion donating solution,

and introducing the sample contacted with said polymer into an ion analysis system.

2. The process of claim 1 wherein said membrane or hollow fiber is immersed in a counter ion donating solution containing alkali metal ions.

3. The process of claim 1 wherein two ion exchange polymers are arranged in series, one of said polymers being immersed in a counter ion donating solution including protons and the other of said polymers being immersed in a counter ion donating solution containing metal cation.

4. The process of any one of claims 1, 2 or 3 wherein said polymer has sulfonic groups.

5. The process of any one of claims 1, 2 or 3 wherein said polymer has carboxylic groups.

6. The process of claim 1 wherein said membrane or hollow fiber is immersed in a counter ion donating solution containing a water soluble sulfonated or carboxylated polymer.

7. The process of claim 1 wherein said bound cation is a transition metal.

8. The process of claim 1 wherein said bound cation is barium or any other alkaline earth cation.

9. The process of claim 1 wherein said bound cation is lead.

10. The process of claim 1 wherein said bound cation is bismuth.

11. The process of claim 1 wherein said bound cation is a metal of lanthanide or actinide series.

13. The process of claim 7 wherein said membrane or hollow fiber is immersed in a counter ion donating solution containing hydroxyl ions said ion exchange polymer being capable of exchanging a bound anion for anion in solution.

15. The process of claim 7 wherein two ion exchange polymers are arranged in series, one of said polymers being immersed in a counter ion donating solution containing hydroxyl ion and the other of said polymers being immersed in a counter ion donating solution containing a second anion.

12. The process for analyzing a sample containing ion species in a solution which comprises:

washing a membrane or hollow fiber formed from an ion exchange polymer to remove substantially all water leachable species from said polymer and to form a washed ion exchange polymer,

said washed ion exchange polymer being immersed in a counter ion donating solution for donating ions comprising said bound ions while avoiding contact of said sample with said counter ion donating solution,

said washed ion exchange polymer being capable of exchanging a bound anion for an anion in solution, while substantially avoiding the introduction of water leachable species in solution,

passing said sample in contact with said washed ion exchange polymer and introducing the sample contacted with said polymer into an ion analysis system.

14. The process of any one of claims 12 or 13 wherein said polymer is aminated.

16. The process for preparing a sample containing ion species in a solution which comprises passing said sample into contact with a membrane or hollow fiber formed from a first ion exchange polymer capable of exchanging bound hydrogen ion for a cation in solution, while substantially avoiding the introduction of water leachable species in solution,

said first ion exchange polymer being immersed in a first solution for donating hydrogen ions while avoiding contact of said sample with said first solution,

passing said sample into contact with a membrane or hollow fiber formed from a second ion exchange polymer capable of exchanging bound hydroxyl for an anion in solution, while substantially avoiding the introduction of water leachable species in solution,

said second ion exchange polymer being immersed in a second solution for donating hydroxyl ions while avoiding contact of said sample with said second solution,

said ion exchange polymers being prewashed to remover substantially all water leachable species from said polymer, and

introducing the sample contacted with said polymer into an ion analysis system.