Biodegradable drug delivery system for the prevention and treatment of osteomyelitis

• US 5,281,419 A
• Filed: 09/28/1992
• Issued: 01/25/1994
• Est. Priority Date: 09/28/1992
• Status: Expired due to Fees

• Current Assignee: Thomas Jefferson University (Main Line Health System)
• Original Assignee: Thomas Jefferson University (Main Line Health System)
• Inventors: Lin, Sheldon S., Tuan, Rocky S.
• Primary Examiner(s): Page, Thurman K.
• Assistant Examiner(s): Kulkosky, Peter F.
• Application Number:
  US07/952,291
• Time in Patent Office: 484 Days
• Field of Search: 424/426
• US Class Current: 424/426
• CPC Class Codes: A61B 17/58 for osteosynthesis, e.g. bone plates, screws , setting implements or the like A61B17/14, A61B17/16 take precedence
• CPC Class Codes: A61L 2300/406 Antibiotics
• CPC Class Codes: A61L 31/06 obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds A61L31/041 takes precedence
• CPC Class Codes: A61L 31/16 Biologically active materials, e.g. therapeutic substances A61L31/047 takes precedence
• CPC Class Codes: C08L 67/04 Polyesters derived from hydroxycarboxylic acids, e.g. lactones C08L67/06 takes precedence

Abstract

An antibiotic impregnated fracture fixation device and antibiotic impregnated drug delivery polymer are provided. In a preferred embodiment, a homogenous mixture of thermally melted poly(lactic) acid and at least one antibiotic and/or antibacterial agent are employed.

Claims

1. A device for treating a fractured bone, comprising a fracture fixation device comprising a pre-formed composite consisting essentially of a homogenous mixture of thermally melted poly(lactic) acid and at least one antibiotic and/or antibacterial agent selected quinoline antibiotics.

2. The fracture fixation device of claim 1 wherein said antibiotic and/or antibacterial agent comprises ciprofloxacin.

3. The fracture fixation device of claim 2 wherein said poly(lactic)acid has an average molecular size ranging from between about 2 to 100 kDa and ciprofloxacin comprises about 5 to 30% (w/w) of said device.

4. The fracture fixation device of claim 3 wherein said poly(lactic) acid has an average molecular size of about 2 kDa and iprofloxacin comprises about 10% (w/w) of said device.

5. The fracture fixation device of claim 3 wherein said poly(lactic) acid has an average molecular size of about 50 kDa and ciprofloxacin comprises about 30% (w/w) of said device.

6. The fracture fixation device of claim 2 further comprising a plate, rod, or pin upon which said composite of thermally melted poly(lactic) acid and ciprofloxacin is concentrically layered.

7. The fracture fixation device of claim 6 wherein the plate, rod, or pin is metallic.

8. The fracture fixation device of claim 1 wherein the composite is in the form of a rod.

9. The fracture fixation device of claim 1 wherein the homogenous mixture is in the form of a plate.

10. The fracture fixation device of claim 1 wherein the homogenous mixture is in the form of a pin.

11. A device for treating a fractured bone, comprising a fracture fixation device consisting essentially of a homogenous mixture of thermally melted poly(lactic) acid having an average molecular size of from 50-100 kDA and ciprofloxacin selected from the group consisting of quinoline and aminoglycoside antibiotics.

12. The fracture fixation device of claim 11 wherein the device is in the form of a rod.

13. The fracture fixation device of claim 11 wherein the device is in the form of a plate.

14. The fracture fixation device of claim 11 wherein the device is in the form of a pin.