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Solid dispersion compositions of tebufelone

  • US 5,281,420 A
  • Filed: 05/19/1992
  • Issued: 01/25/1994
  • Est. Priority Date: 05/19/1992
  • Status: Expired due to Fees
First Claim
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1. A composition comprising a solid dispersion which is a solidified homogeneous melt mixture comprising the following components:

  • (a) from about 15% to about 75% of tebufelone;

    (b) from about 25% to about 65% of a poloxamer surfactant having a melting point of about 40°

    C. or greater, the poloxamer surfactant consisting essentially of a block copolymer having three polymer blocks, a middle block of poly(oxypropylene) with a molecular weight of from about 1450 to about 6000 daltons, and end blocks of poly(oxyethylene), the end blocks being from about 50% to about 90% by weight of the copolymer;

    wherein components of the solid dispersion are substantially uniformly dispersed therein.

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