Solid dispersion compositions of tebufelone
First Claim
1. A composition comprising a solid dispersion which is a solidified homogeneous melt mixture comprising the following components:
- (a) from about 15% to about 75% of tebufelone;
(b) from about 25% to about 65% of a poloxamer surfactant having a melting point of about 40°
C. or greater, the poloxamer surfactant consisting essentially of a block copolymer having three polymer blocks, a middle block of poly(oxypropylene) with a molecular weight of from about 1450 to about 6000 daltons, and end blocks of poly(oxyethylene), the end blocks being from about 50% to about 90% by weight of the copolymer;
wherein components of the solid dispersion are substantially uniformly dispersed therein.
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Accused Products
Abstract
The subject invention relates to compositions in dosage form comprising a solid dispersion which is a solidified melt mixture consisting essentially of the following components:
(a) from about 15% to about 75% of tebufelone;
(b) from about 25% to about 65% of a poloxamer surfactant having a melting point of about 40° C. or greater, the poloxamer surfactant consisting essentially of a block copolymer having three polymer blocks, a middle block of poly(oxypropylene) with a molecular weight of from about 1450 daltons to about 6000 daltons, and end blocks of poly(oxyethylene), the end blocks being from about 50% to about 90% of the copolymer; and
(c) from 0% to about 60% of other components, wherein the other components are miscible with a melt mixture of components (a) and (b).
101 Citations
21 Claims
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1. A composition comprising a solid dispersion which is a solidified homogeneous melt mixture comprising the following components:
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(a) from about 15% to about 75% of tebufelone; (b) from about 25% to about 65% of a poloxamer surfactant having a melting point of about 40°
C. or greater, the poloxamer surfactant consisting essentially of a block copolymer having three polymer blocks, a middle block of poly(oxypropylene) with a molecular weight of from about 1450 to about 6000 daltons, and end blocks of poly(oxyethylene), the end blocks being from about 50% to about 90% by weight of the copolymer;wherein components of the solid dispersion are substantially uniformly dispersed therein. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21)
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Specification