Non-invasive method for detecting deep venous thrombosis in the human body

• US 5,282,467 A
• Filed: 08/13/1992
• Issued: 02/01/1994
• Est. Priority Date: 08/13/1992
• Status: Expired due to Term

• Current Assignee: Duke University
• Original Assignee: Duke University
• Inventors: Comfort, Benjamin J., Hampson, Neil B., Piantadosi, Claude A.
• Primary Examiner(s): Sykes, Angela D.
• Application Number:
  US07/930,002
• Time in Patent Office: 537 Days
• Field of Search: 128/672, 128/633, 128/664, 128/665, 128/677, 128/666, 128/667, 356/39-41
• US Class Current: 600/335
• CPC Class Codes: A61B 5/02007 Evaluating blood vessel condition, e.g. elasticity, compliance
• CPC Class Codes: A61B 5/02416 using photoplethysmograph signals, e.g. generated by infrared radiation A61B5/14552 takes precedence
• CPC Class Codes: A61B 5/1455 using optical sensors, e.g. spectral photometrical oximeters

Abstract

A non-invasive method for detecting deep venous thrombosis in a human body wherein changes are effected in the amount of deoxyhemoglobin in the body limb by trapping blood in the venous system for a determinate time period and then releasing the trapped blood in the venous system. During the period that the changes in the amount of deoxyhemoglobin are effected, first and second light sources emit light of two selected wavelengths which penetrate into the deep venous system of the body limb so that the reflectance contributions can be used to measure changes in the flow and amount of deoxyhemoglobin and to thereby detect the presence or absence of deep venous thrombosis.

Claims

1. A non-invasive method for detecting deep venous thrombosis in a human body, said method comprising the steps of:

(a) securing an inflatable cuff to a body limb of interest wherein said body limb comprises skin, tissues, oxyhemoglobin and deoxyhemoglobin;

(b) attaching a radiation source and operatively associated photodetector to the body limb proximate to said inflatable cuff;

(c) actuating said radiation source so that radiation penetrates through the skin and into the deep venous system of the body limb to enable detecting of changes in the amount of deoxyhemoglobin in said deep venous system;

(d) effecting changes in the amount of deoxyhemoglobin in the body limb by inflating said cuff during said radiation source actuation to a pressure below arterial pressure to trap blood in the venous system for a determining a time period and by deflating said cuff during said same radiation source actuation;

(e) actuating said photodetector to detect changes occurring during the trapping of the blood in the venous system after said cuff is inflated and during the emptying of the venous system after said cuff is deflated by measuring reflectance contributions including contribution from the skin, tissues, oxyhemoglobin and deoxyhemoglobin of the body limb; and

(f) detecting the presence of deep venous thrombosis by subtracting the reflectance contributions of the skin, tissues and oxyhemoglobin from the reflectance contribution of the deoxyhemoglobin and comparing the reflectance contribution of the deoxyhemoglobin to predetermined reflectance values for a normal body limb.

2. A non-invasive method for detecting deep venous thrombosis according to claim 1 wherein said radiation source comprises at least two light sources.

3. A method according to claim 2 wherein said at least two light sources comprise two light sources wherein said emitted light from said first light source has a wavelength between about 600 to 800 nanometers and emitted light from said second light source has a wavelength between a bout 800 to 1000 nanometers.

4. A method according to claim 2 wherein said at least two light sources comprise at least one light-emitting diode (LED).

5. A method according to claim 1 wherein said inflatable cuff and said radiation source and operatively associated photodetector are electrically connected to and controlled by a computer.

6. A method according to claim 5 wherein said deep venous thrombosis detecting step is calculated by said computer.

7. A non-invasive method for detecting deep venous thrombosis in a human body, said method comprising the steps of:

(a) securing an inflatable cuff to a body limb of interest wherein said body limb comprises skin, tissues, oxyhemoglobin and deoxyhemoglobin;

(b) attaching first and second light sources and an operatively associated photodetector to the body limb proximate to said inflatable cuff, said first light source emitting light having a wavelength between about 600 to 800 nanometers and said second light source emitting light having a wavelength between about 800 to 1000 nanometers;

(c) actuating said first and second light sources so that light emitted therefrom penetrates through the skin and into the deep venous system of the body limb to enable detecting of changes in the amount of deoxyhemoglobin in said deep venous system;

(d) effecting changes in the amount of deoxyhemoglobin in the body limb by inflating said cuff during said light source actuation to a pressure below arterial pressure to trap blood in the venous system for a determinate time period and by deflating said cuff during said same light source actuation to release blood from the venous system;

(e) actuating said photodetector to detect changes occurring during the trapping of the blood in the venous system after said cuff is inflated and during the emptying of the venous system after said cuff is deflated by measuring light reflectance contributions from said first and second light sources including contributions from the skin, tissues, oxyhemoglobin and deoxyhemoglobin of the body limb; and

(f) detecting the presence of deep venous thrombosis by subtracting the reflectance contributions of the skin, tissues and oxyhemoglobin from the reflectance contribution of the deoxyhemoglobin and comparing the reflectance contribution of the deoxyhemoglobin to predetermined reflectance values for a normal body limb.

8. A method according to claim 7 wherein said light sources comprise one light-emitting diode (LED) and one continuous wave (CW) laser diode.

9. A method according to claim 7 wherein said emitted light from said first light source is absorbed primarily by said deoxyhemoglobin, skin and tissues and said emitted light from said second light source is absorbed primarily by said oxyhemoglobin, deoxyhemoglobin, skin and tissue.

10. A method according to claim 7 wherein said inflatable cuff and said first and second light sources and operatively connected photodetector are electrically connected to and controlled by a computer.

11. A method according to claim 10 wherein said deep venous thrombosis detecting step is calculated by said computer.

12. A method according to claim 10 wherein said computer comprises an electronic computer and interface system.

13. A non-invasive method for detecting deep venous thrombosis in a human body, said method comprising the steps of:

(a) securing an inflatable cuff to a leg wherein said leg comprises skin, tissues, oxyhemoglobin and deoxyhemoglobin;

(b) attaching a radiation source and operatively associated photodetector to the leg proximate to said inflatable cuff;

(c) actuating said radiation source sot hat radiation penetrates through the skin and into the deep venous system of the leg to enable detecting of changes in the amount of deoxyhemoglobin in said deep venous system;

(d) effecting changes in the amount of deoxyhemoglobin in the leg by inflating said cuff during said radiation source actuation to a pressure below arterial pressure to trap blood in the venous system for a determinate time period and by deflating said cuff during said same radiation source actuation to release blood from the venous system;

(e) actuating said photodetector to detect changes occurring during the trapping of the blood in the venous system after said cuff is inflated and during the emptying of the venous system after said cuff is deflated by measuring reflectance contributions including contributions from the skin, tissues, oxyhemoglobin and deoxyhemoglobin of the leg; and

(f) detecting the presence of deep venous thrombosis by subtracting the reflectance contributions of the skin, tissues and oxyhemoglobin from the reflectance contribution of the deoxyhemoglobin and comparing the reflectance contribution of the deoxyhemoglobin to predetermined reflectance values for a normal leg.

14. A non-invasive method for detecting deep venous thrombosis in a human body, said method comprising the steps of:

(a) securing an inflatable cuff to a leg wherein said leg comprises skin, tissues, oxyhemoglobin and deoxyhemoglobin;

(b) attaching first and second light sources and an operatively associated photodetector to the leg proximate to said inflatable cuff, said first light source emitting light having a wavelength between about 600 to 800 nanometers and said second light source emitting light having a wavelength between about 800 to 1000 nanometers;

(c) actuating said first and second light sources so that light emitted therefrom penetrates through the skin and into the deep venous system of the leg to enable detecting of changes int he amount of deoxyhemoglobin in said deep venous system;

(d) effecting changes int he amount of deoxyhemoglobin in the leg by inflating said cuff during said light source actuation to a pressure below arterial pressure to trap blood in the venous system for a determinate time period and by deflating said cuff during said same light source actuation to release blood from the venous system;

(e) actuating said photodetector to detect changes occurring during the trapping of the blood int eh venous system after said cuff is inflated and during the emptying of the venous system after said cuff is deflated by measuring light reflectance contributions from said first and second light sources including contributions from the skin, tissues, oxyhemoglobin and deoxyhemoglobin of the leg; and

(f) detecting the presence of deep venous thrombosis by subtracting the reflectance contributions of the skin, tissues and oxyhemoglobin from the reflectance contribution of the deoxyhemoglobin and comparing the reflectance contribution of the deoxyhemoglobin to predetermined reflectance values for a normal leg.