Cover for array of reaction tubes

• US 5,282,543 A
• Filed: 01/11/1993
• Issued: 02/01/1994
• Est. Priority Date: 11/29/1990
• Status: Expired due to Term

• Current Assignee: Applied Biosystems LLC (Thermo Fisher Scientific Incorporated)
• Original Assignee: Perkinelmer Incorporated
• Inventors: Keese, Ralph, Woudenberg, Timothy M., Ragusa, Robert, Picozza, Enrico
• Primary Examiner(s): NOT, DEFINED
• Assistant Examiner(s): Trembley, Theresa A.
• Application Number:
  US08/002,559
• Time in Patent Office: 386 Days
• Field of Search: 422/99, 422/102, 435/287, 435/293, 435/300, 435/301, 435/316, 435/809, 100/211, 220/524, 220/525, 220/526, 220/23.4, 220/23.83, 220/255, 428/132, 428/137, 428/172
• US Class Current: 220/255
• CPC Class Codes: B01L 2200/147 Employing temperature sensors
• CPC Class Codes: B01L 2300/042 Caps; Plugs
• CPC Class Codes: B01L 2300/046 Function or devices integrated in the closure
• CPC Class Codes: B01L 2300/0829 Multi-well plates; Microtitration plates
• CPC Class Codes: B01L 2300/1822 using Peltier elements
• CPC Class Codes: B01L 2300/1827 using resistive heater
• CPC Class Codes: B01L 2300/185 using a liquid as fluid
• CPC Class Codes: B01L 3/50825 Closing or opening means, corks, bungs closures for containers B65D; means for removing stoppers B67B7/02
• CPC Class Codes: B01L 3/5085 for multiple samples, e.g. microtitration plates
• CPC Class Codes: B01L 3/50851 specially adapted for heating or cooling samples laboratory heating apparatus B01L7/00; incubators C12M
• CPC Class Codes: B01L 3/50853 with covers or lids
• CPC Class Codes: B01L 7/00 Heating or cooling apparatus autoclaves B01J3/04; Heat insulating devices
• CPC Class Codes: B01L 7/52 with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples amplification or hybridisation processes per se C12Q1/68; controlling sequential reactions for synthesis B01J19/0046

Abstract

An array of reaction tube covers adapted to seal a plurality of reaction tubes comprises a unitary body of flexible material having a plurality of flexible plastic nodules. Each nodule is adapted to seal one of the reaction tubes. Each of the nodules is flexible held in a predetermined planar spaced relationship from each other in rows, preferably in rows and columns, by an integral web having a plurality of apertures therethrough. Each of the nodules has a downwardly convex, generally hemispherical lower portion extending from the web, an upwardly convex upper portion extending from the web over the lower portion, and a centrally domed nipple extending upwardly from the upper portion.

Claims

1. A planar array of reaction tube covers adapted to seal a plurality of reaction tubes arranged in a predetermined special arrangement, said planar array comprising:

a plurality of nodules held in a predetermined spaced relationship from each other by a web, each of said nodules being capable of fitting into and sealing an open end of one of a plurality of reaction tubes, each of said nodules having a lower portion for fitting within said open end and an upwardly convex upper portion directly above said lower portion.

2. The planar array according to claim 1 wherein said lower and upwardly convex portions are integrally connected to said web.

3. The planar array according to claim 1 wherein said web has a plurality of apertures therethrough spaced between said plurality of nodules.

4. The planar array according to claim 1 wherein said array is a molded unitary rubber body.

5. The planar array according to claim 4 wherein said molded unitary rubber body is silicon rubber.

6. The planar array according to claim 1 wherein said lower portion has a solid generally hemispherical shape.

7. A planar array of reaction tube covers adapted to seal a plurality of reaction tubes arranged in a predetermined spacial arrangement, said planar array comprising:

a plurality of flexible plastic nodules connected in a predetermined spaced relationship from each other by a web, each of said nodules being capable of fitting into and sealing an open end of one of a plurality of reaction tubes, each of said flexible plastic nodules having a downwardly convex lower portion, an upwardly convex upper portion directly above said downwardly convex lower portion, and a nipple extending upward from said upwardly convex upper portion.

8. The planar array according to claim 7 wherein said array is a molded unitary body made of silicone rubber.

9. The planar array according to claim 8 wherein said nipple is centered above said upwardly convex upper and downwardly convex lower portions and has a dome shape.

10. The planar array according to claim 9 wherein said web has a plurality of apertures therethrough spaced between said plurality of flexible plastic nodules.

11. The planar array according to claim 7 wherein said downwardly convex lower portion has a generally hemispherical shape.

12. An array of reaction tube covers adapted to seal a plurality of reaction tubes comprising:

a unitary body having a plurality of flexible plastic nodules, each adapted to seal one of a plurality of reaction tubes, each of said flexible plastic nodules being flexibly held in a predetermined planar spaced relationship from each other in rows and columns by an integral web having a plurality of apertures therethrough, each of said nodules having a downwardly convex generally hemispherical lower portion extending from said web, an upwardly convex upper portion extending from said web directly above said downwardly convex generally hemispherical lower portion, and a centrally domed nipple extending upward from said upwardly convex upper portion.

13. A planar array of reaction tube covers adapted to seal a plurality of reaction tubes arranged in a predetermined special arrangement, said planar array comprising:

a plurality of nodules held in a predetermined spaced relationship from each other by a web, each of said nodules being capable of fitting into and sealing an open end of one of a plurality of reaction tubes, each of said nodules having a lower portion for fitting within said open end and an upwardly extending upper portion directly above said lower portion.

14. The planar array according to claim 13 wherein said lower and upper portions are integrally connected to said web.

15. The planar array according to claim 13 wherein said web has a plurality of apertures therethrough spaced between said plurality of nodules.

16. The planar array according to claim 13 wherein said array is a molded unitary rubber body.

17. The planar array according to claim 16 wherein said molded unitary rubber body is silicone rubber.

18. The planar array according to claim 13 wherein said lower portion has a solid generally hemispherical shape.