Large intestinal dissociative hard capsules

• US 5,283,064 A
• Filed: 06/04/1991
• Issued: 02/01/1994
• Est. Priority Date: 06/04/1990
• Status: Expired due to Term

• Current Assignee: Aicello Chemical Co., Ltd.
• Original Assignee: Aicello Chemical Co., Ltd.
• Inventors: Matsumoto, Takayuki, Hashiudo, Kenichi, Higashide, Toshihiro, Fujii, Takeru, Suzuki, Tsutomu
• Primary Examiner(s): Page, Thurman K.
• Assistant Examiner(s): Harrison, Robert H.
• Application Number:
  US07/709,978
• Time in Patent Office: 973 Days
• Field of Search: 424/451, 424/459, 424/461, 424/463, 424/436, 424/438, 424/451, 514/808, 514/3, 536/20
• US Class Current: 424/451
• CPC Class Codes: A61K 9/4816 Wall or shell material
• CPC Class Codes: A61K 9/4891 Coated capsules; Multilayered drug free capsule shells with drug coating for immediate release A61K9/4808; osmotic devices A61K9/0004

Abstract

A large intestinal dissociative hard capsule comprising a capsule mainly composed of chitosan, the viscosity at 20° C. of a solution obtained by dissolving the chitosan in an aqueous 1% by weight acetic acid solution being not higher than 100 cps and the degree of deacetilation of the chitosan being from 60 mol % to 98 mol %, having a coated layer of a polymer soluble in a liquid having pH of at least 5 on the surface of the capsule.

Claims

1. A large intestinal dissociative hard capsule for oral administration comprising a capsule consisting essentially of chitosan, the viscosity at 20°

C. of a solution obtained by dissolving the chitosan in an aqueous 1% by weight acetic acid solution at a concentration of 1% by weight being not higher than 100 cps and the degree of deacetylation of the chitosan being from 60 mol % to 98 mol %, having a coated layer of a polymer soluble in a liquid having pH of at least 5 on the surface of the capsule.

4. The large intestinal dissociative capsule of any one of claims 1 to 3, wherein the polymer soluble in a liquid having pH of at least 5 is at least one kind of polymer selected from a methacrylic acid-methyl methacrylate copolymer, a methacrylic acid-ethyl acrylate copolymer, hydroxypropylmethyl cellulose acetate and succinate, and hydroxypropylmethyl cellulose phthalate.

5. The large intestinal dissociative hard capsule of any one of claims 1 to 3, wherein the surface of the capsule is subjected to an alkali treatment to increase its water resistance.

2. A large intestinal dissociative hard capsule for oral administration, wherein the capsule is composed of chitosan, the viscosity at 20°

C. of a solution obtained by dissolving the chitosan in an aqueous 1% by weight acetic acid solution at a concentration of 1% by weight being no higher than 100 cps and the degree of deacetylation of the chitosan being from 60 mol % to 98 mol %, and a capsule dissociating agent, having a coated layer of a polymer soluble in a liquid having pH of at least 5 on the surface of the capsule.

3. The large intestinal dissociative hard capsule of claim 2, wherein the capsule dissociating agent is at least one kind of polysaccharide selected from a cellulose and its derivatives powder, a grain powder, starch powder, processed starch powder, and oligosaccharide powder.