Device for the transnasal or oral administration of drugs or the like

• US 5,284,132 A
• Filed: 04/09/1991
• Issued: 02/08/1994
• Est. Priority Date: 04/17/1990
• Status: Expired due to Fees

• Current Assignee: Coster Tecnologie Speciali S.p.A.
• Original Assignee: Coster Tecnologie Speciali S.p.A.
• Inventors: Geier, Adalbert
• Primary Examiner(s): Burr, Edgar S.
• Assistant Examiner(s): Asher, Kimberly L.
• Application Number:
  US07/682,464
• Time in Patent Office: 1,036 Days
• Field of Search: 128/200.14, 128/200.21, 128/200.22, 128/203.21, 128/203.23, 128/203.24, 128/203.12, 604/26, 604/71, 604/131, 604/133, 604/181, 604/218, 604/224, 604/228, 604/236, 604/237, 604/94
• US Class Current: 128/200.22
• CPC Class Codes: A61M 11/02 operated by air or other gas pressure applied to the liquid or other product to be sprayed or atomised sprayers for horticulture A01G, A01H; killing insects A01M; air humidifying by nozzles F24F6/14, F24F6/18; cooling by spraying F28B, F28C
• CPC Class Codes: A61M 15/08 Inhaling devices inserted into the nose
• CPC Class Codes: A61M 2205/073 Syringe, piston type
• CPC Class Codes: A61M 2206/16 Rotating swirling helical flow, e.g. by tangential inflows
• CPC Class Codes: B05B 1/14 with multiple outlet openings B05B1/02, B05B1/26 take precedence; with strainers in or outside the outlet opening
• CPC Class Codes: B05B 11/007 being opened by deformation of a sealing element made of resiliently deformable material, e.g. flaps, skirts, duck-bill valves
• CPC Class Codes: B05B 11/0097 Means for filling or refilling the sprayer through additional openings in the container B05B11/0056
• CPC Class Codes: B05B 11/02 Membranes or pistons acting on the contents inside the container, e.g. follower pistons
• CPC Class Codes: B05B 11/025 with stepwise advancement of the piston, e.g. for spraying a predetermined quantity of content

Abstract

A device for the transnasal or oral administration of drugs or similar media, comprising a finger-like applicator (3) which has a spray nozzle (6) disposed at its free end and includes a cylinder unit (1) for accommodating the medium to be administered. The medium is applied by moving a piston (7) into the cylinder unit (1). A membrane-like seal (4) is located between the cylinder unit and spray nozzle and is slotted to open and form a fluid passage under pressure. The cylinder unit may be built into the applicator or may include a separate cartridge releasably mounted in the applicator. The piston may be activated in steps or in a continuous motion. A second applicator may be attached to the side of the first applicator with the spray nozzles located generally in accordance with spacing of human nose nostrils.

Claims

1. A device for the administration of fluid drugs or similar fluid media to a patient by a human operator, comprising a finger-like applicator (3) having a spray nozzle (6) disposed at the free end thereof and a cylinder unit (1) for accommodating the media to be administered, a piston (7) having an inner end located within the cylinder unit and having an outer actuating end (20) projecting from the cylinder unit, said outer actuating end engagable by the fingers of the human operator for movement of said inner end through the cylinder unit (1) and forcing the media through the spray nozzle (6), the improvement comprising a substantially flat membrane seal (4) located between the cylinder unit and the spray nozzle, said membrane seal having an outer peripheral edge secured to said cylinder unit and spray nozzle having a central flexible portion having a first side exposed to the cylinder unit and a second side exposed to the spray nozzle, said central flexible portion including at least one slot portion forming a normally closed fluid passage, said flexible portion of said membrane seal being deflected adjacent said slot in response to a selected pressure applied to said membrane seal to open said fluid passage, said first and second sides of said central flexible portion of said membrane seal being unsupported and free to deflect toward said cylinder unit or toward said spray nozzle, said selected pressure generated by movement of said piston by the operator forcing said media from the cylinder unit and deflecting said flexible portion to open said slot portion of said membrane seal and transfer the media into the spray nozzle (6), means for coupling and loading said nozzle and said cylinder unit with pressurized source of said media, said selective pressure deflecting said flexible portion toward said cylinder unit to open said slot and transfer media into said cylinder unit from said pressurized source of said media.

2. The device of claim 1, having a transfer passage (22) between said cylinder unit (1) and said spray nozzle (6) and wherein said membrane seal (4) is disposed in said passage (22) between said cylinder unit (1) and the spray nozzle (6), and a clamp unit securing said peripheral edge of said membrane seal to said transfer passage, and said slot portion being located generally centrally of said transfer passage.

3. The device of claim 1, wherein said piston has an initial position in said cylinder unit (1) with said actuating end remote from the spray nozzle (6) for moving said piston, a releasable locking mechanism connected to the piston (7) for holding the piston in the initial position, said locking mechanism released in response to a release pressure on the piston actuating end (20).

4. The device in claim 3, including a guide cylinder (11) connected to the finger-like applicator (3), a cylinder cup (8) within said guide cylinder (11) and opening towards the spray nozzle (6), said cup connected to said piston and forming said actuating end (20) and extending coaxially with the piston (7).

5. The device in claim 4, wherein the locking mechanism includes a protrusion (21) on the cylinder cup (8) and a complementary groove (12, 13) on the inside of the guide cylinder (11).

6. The device in claim 5, wherein said groove is an annular groove on the inside of the guide cylinder (11) remote from the spray nozzle (6), said groove including a stop member (12) to prevent withdrawal of the piston (7) from the cylinder unit (1) of the applicator (3).

7. The device of claim 1, wherein the piston (7) moves intermittently, said outer actuating end (20) constructed and arranged at the end of the piston (7) remote from the spray nozzle (6) for establishing the intermittent movement in response to a selected force applied to said actuating end (20).

8. The device of claim 7, wherein the outer actuating end (20) includes a guide cylinder (15) connected to the finger-like applicator (3) and having stepped guide means (16) including a plurality of steps each having a guide (31), a cylinder cup (18) located in said guide cylinder and connected to said outer actuating end (20), said cup opening towards the spray nozzle (6) and extending coaxially with the piston (7), at least one radially extending projection (17) on the cylinder cup (18) engaging said stepped guide means (16) including said guide (31), means for establishing piston movement and to discharge a selected dose of the media, said means comprising said cup, said guide cylinder, and said guide, wherein said cup is turned and axially moved relative to the guide cylinder (15) and said guide (31) of said guide means.

9. The device of claim 8, wherein said guide cylinder (15) has a cylinder wall, said stepped guide means (16) is configured as holes through the cylinder wall, an outer cover cylinder (14) extends over the guide cylinder (15), said cover cylinder (15) having a free peripheral edge (26) remote from the spray nozzle (6) and turned inward to define a stop element for preventing withdrawal of the cup (18) and thereby said piston (7) from said cylinder unit (1).

10. The device of claim 9, wherein said cylinder cup has an outer surface and includes circumferentially spaced division indicia (19) on said outer surface, said peripheral edge (26) includes a marking unit (27) aligned with said division indicia (19) on the outer surface of the cylinder cup (18) in response to said turning and moving said cup, and wherein the circumferential distance between the division indicia (19) corresponds to the circumferential pitch of the stepped guide means (16) and to the respective circumferential spacing between adjacent guide steps (31), respectively.

11. The device of claim 10, wherein said free peripheral edge of the cylinder cup (18) includes a knurled portion (28).

12. The device of claim 8, wherein each guide step (31) includes an axially extending portion and a detent member (32, 33) cooperating therewith for permitting application movement of the piston (7) while blocking return movement thereof.

13. The device of claim 1, having said outer actuating end (20) connected to said piston and a piston member in said cartridge and a radially projecting member (2) on the end of the finger-like applicator (3) remote from the spray nozzle (6), said projecting member adapted to support the user'"'"'s index and middle fingers for actuation of the piston (7) by thumb pressure against the outer actuating end (20).