Tonometry system for determining blood pressure

• US 5,284,150 A
• Filed: 10/16/1992
• Issued: 02/08/1994
• Est. Priority Date: 11/30/1990
• Status: Expired due to Term

• Current Assignee: Carefusion 303 Incorporated (Becton, Dickinson & Co)
• Original Assignee: Ivax Corporation (Teva Pharmaceutical Industries, Ltd.)
• Inventors: Butterfield, Robert D., Martin, Stephen A., Holdaway, Charles R., Pytel, Kenneth J.
• Primary Examiner(s): Cohen, Lee S.
• Assistant Examiner(s): PONTIUS, KEVIN LANE
• Application Number:
  US07/962,364
• Time in Patent Office: 480 Days
• Field of Search: 128/633-634, 128/672, 128/687-690, 128/748, 73/705, 73/715, 73/728
• US Class Current: 600/485
• CPC Class Codes: A61B 2560/0252 using ambient temperature
• CPC Class Codes: A61B 2562/0247 Pressure sensors
• CPC Class Codes: A61B 2562/043 in a linear array
• CPC Class Codes: A61B 5/021 Measuring pressure in heart or blood vessels A61B5/0205 takes precedence
• CPC Class Codes: A61B 5/02422 within occluders
• CPC Class Codes: A61B 5/7203 for noise prevention, reduction or removal

Abstract

A tissue contact stress sensing system incorporates a semiconductor assembly and a continuous diaphragm to noninvasively determine the intra-arterial blood pressure of a patient. The system comprises a continuous diaphragm placed against a patient'"'"'s tissue which covers an underlying artery. The semiconductor assembly is placed in close proximity to and spaced apart from the diaphragm for directly irradiating the diaphragm with electromagnetic radiation and receiving a portion of the electromagnetic radiation which is reflected from the continuous diaphragm. The disclosed system also utilizes a technique for minimizing the system errors associated with temperature drift and aging of the sensor.

Claims

1. For use in a system for noninvasively determining the intra-arterial blood pressure of a patient, a tissue contact stress sensing apparatus comprising:

a continuous diaphragm,

means for placing said continuous diaphragm against a patient'"'"'s tissue which covers an underlying artery, said diaphragm adapted to deform in response to stress in said tissue caused by the intra-arterial blood pressure of said artery,

semiconductor means placed in close proximity to and spaced apart from said continuous diaphragm for irradiating said diaphragm with electromagnetic radiation,

means for receiving said electromagnetic radiation reflected from said continuous diaphragm,

whereby the quantity of electromagnetic radiation received by said receiving means is a function of the displacement of said continuous diaphragm in response to said tissue stress caused by said intra-arterial blood pressure of said artery.

2. The tissue contact stress sensing apparatus of claim 1 wherein said diaphragm is comprised of silicon.

3. The tissue contact stress sensing apparatus of claim 2, wherein said diaphragm is comprised of single crystal silicon.

4. The tissue contact stress sensing apparatus of claim 2, wherein said diaphragm is formed from a silicon wafer.

5. The tissue contact stress sensing apparatus of claim 4, wherein said diaphragm is formed from a longitudinal trough in said silicon wafer and said trough includes a cross-sectional profile generally resembling a tetragonal-pyramidal geometry.

6. The tissue contact stress sensing apparatus of claim 5, wherein said trough has a generally planar bottom.

7. The tissue contact stress sensing apparatus of claim 1, wherein said diaphragm is formed from a silicon wafer and wherein said wafer includes a longitudinal trough therein forming one side of said diaphragm, and wherein said trough has a bottom which is coated with a reflective material for reflecting the electromagnetic radiation irradiated by said irradiating means.

8. The tissue contact stress sensing apparatus of claim 7, wherein said trough bottom is generally 6.5×

10^-6 meters thick.

9. The tissue contact stress sensing apparatus of claim 7, wherein said trough bottom is coated with metal.

10. The tissue contact stress sensing apparatus of claim 9, wherein said metal is selected from the group consisting of gold and aluminum.

11. The tissue contact stress sensing apparatus of claim 9, wherein said metal coating is generally 600 angstroms thick.

12. For use in a system for noninvasively determining the intra-arterial blood pressure of a patient, a tissue contact stress sensor for generating a tissue contact stress signal indicative of said intra-arterial blood pressure and a correction signal for compensating for errors in said tissue contact stress signal caused by temperature drift and aging of said sensor, said system comprising:

a continuous diaphragm having a responsive portion and a non-responsive portion,

means for placing said responsive portion against a patient'"'"'s tissue which covers an underlying artery, said responsive portion adapted to deform in response to said intra-arterial blood pressure of said artery,

semiconductor means, spaced apart from and placed in close proximity to said continuous diaphragm, for irradiating said continuous diaphragm with electromagnetic radiation,

means for receiving said electromagnetic radiation reflected from said responsive portion and said non-responsive portion of said continuous diaphragm,

means for converting said radiation received from said responsive portion of said continuous diaphragm into a tissue contact stress signal representing intra-arterial blood pressure data,

means for converting said radiation received from said non-responsive portion of said continuous diaphragm into a correction signal which represents reference data which is indicative of at least one reference factor, and

means for combining said correction signal with said tissue contact stress signal thereby minimizing the dependence of said blood pressure data on at least one of said reference factors.

13. The tissue contact stress sensor of claim 12, wherein said reference factors include temperature and aging of said diaphragm.

14. The tissue contact stress sensor of claim 12, wherein said responsive and non-responsive portions of said continuous diaphragm are fabricated from substantially the same materials and at substantially the same time.

15. The tissue contact stress sensor of claim 12, wherein said continuous diaphragm is comprised of single crystal silicon.

16. The tissue contact stress sensor of claim 12, wherein said electromagnetic radiation is selected from the group consisting of visible, infrared, and ultraviolet light.

17. The tissue contact stress sensor of claim 12, wherein said continuous diaphragm is comprised of a silicon base having a longitudinal trough therein.

18. The tissue contact stress sensor of claim 17, wherein said trough has a generally planar bottom.

19. The tissue contact stress sensor of claim 18, wherein said trough bottom is generally 6.5×

10^-6 meters thick.