Filament fabricated from a blend of ionomer resin and nonionic thermoplastic resin

• US 5,284,489 A
• Filed: 08/19/1992
• Issued: 02/08/1994
• Est. Priority Date: 08/19/1992
• Status: Expired due to Term

• Current Assignee: United States Surgical Corporation (Medtronic Plc)
• Original Assignee: United States Surgical Corporation (Medtronic Plc)
• Inventors: Brewer, John C., Liu, Cheng-Kung
• Primary Examiner(s): Green, Randall L.
• Assistant Examiner(s): PREBILIC, PAUL B
• Application Number:
  US07/932,377
• Time in Patent Office: 538 Days
• Field of Search: 623/11, 623/13, 606/228, 606/230, 606/231, 606/151, 526/351, 525/240, 525/196, 525/221
• US Class Current: 606/228
• CPC Class Codes: A61B 90/00 Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges protective face masks A41D13/11; surgeon's or patient's gowns or dresses A41D13/12; devices for carrying-off, for treatment of, or for carrying-over, body liquids A61M1/00
• CPC Class Codes: A61L 17/04 Non-resorbable materials
• CPC Class Codes: A61L 31/041 Mixtures of macromolecular compounds
• CPC Class Codes: C08L 33/00 Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
• CPC Class Codes: D01F 6/46 of polyolefins

Abstract

A filament is fabricated from a biologically acceptable blend of an ionomer resin such as an ionically crosslinked ethylene-methacrylic acid copolymer and a nonionic thermoplastic resin, e.g., a polyolefin such as an isotactic polypropylene.

Claims

1. A medical device comprising a filament fabricated from a biologically acceptable resin blend comprising ionomer resin and nonionic thermoplastic resin.

2. The device of claim 1 wherein the blend contains from about 1 to about 95 parts by weight of ionomer resin based on the total weight of the blend.

3. The device of claim 1 wherein the blend contains from about 2 to about 50 parts by weight of ionomer resin based on the total weight of the blend.

4. The device of claim 1 wherein the blend contains from about 5 to about 20 parts by weight of ionomer resin based on the total weight of the blend.

5. The device of claim 1 wherein the ionomer resin is based on a copolymer of at least one alpha olefin and a member selected from the group consisting of ethylenically unsaturated carboxylic acids and carboxylic acid anhydrides.

6. The device of claim 1 wherein the ionomer resin is based on a copolymer of ethylene and methacrylic acid.

7. The device of claim 1 wherein the nonionic thermoplastic resin is a polyolefin.

8. The device of claim 1 wherein the nonionic thermoplastic resin is a crystalline polypropylene.

9. The device of claim 1 wherein the nonionic thermoplastic resin is an isotactic polypropylene having a melt flow index, in g/10 min, of from about 2 to about 6.

10. The device of claim 1 wherein the blend contains from about 1 to about 40 parts by weight of ionomer resin, the ionomer resin is based on a copolymer of an alpha olefin and an ethylenically unsaturated carboxylic acid and the nonionic thermoplastic resin is an isotactic polypropylene.

11. A suture fabricated from a biologically acceptable resin blend comprising ionomer resin and nonionic thermoplastic resin.

12. The suture of claim 11 which is of monofilament construction.

13. The suture of claim 11 which is of multifilament construction.

14. The suture of claim 11 wherein the blend contains from about 1 to about 99 parts by weight of ionomer resin based on the total weight of the blend.

15. The suture of claim 11 wherein the blend contains from about 2 to about 50 parts by weight of ionomer resin based on the total weight of the blend.

16. The suture of claim 11 wherein the blend contains from about 5 to about 20 parts by weight of ionomer resin based on the total weight of the blend.

17. The suture of claim 11 wherein the ionomer resin is based on a copolymer of at least one alpha olefin at a member selected from the group consisting of ethylenically unsaturated carboxylic acids and carboxylic acid anhydrides.

18. The suture of claim 11 wherein the ionomer resin is based on a copolymer of ethylene and methacrylic

19. The suture of claim 11 wherein the nonionic thermoplastic resin is a polyolefin.

20. The suture of claim 11 wherein the nonionic thermoplastic resin is a crystalline polypropylene.

21. The suture of claim 11 wherein the nonionic thermoplastic resin is an isotactic polypropylene having a melt flow index, in g/10 min, of from about 2 to about 6.

22. The suture of claim 11 wherein the nonionic thermoplastic resin is an isotactic polypropylene having a melt flow index, in g/10 min, of from about 2.5 to about 4.5.

23. The suture of claim 11 wherein the nonionic thermoplastic resin is an isotactic polypropylene possessing a weight average molecular weight of from about 200,000 to about 350,000 and a number average molecular weight of from about 50,000 to about 180,000.

24. The suture of claim 11 wherein the blend contains from about 1 to about 40 parts by weight of ionomer resin, the ionomer resin is based on a copolymer of an alpha olefin and an ethylenically unsaturated carboxylic acid and the nonionic thermoplastic resin is an isotactic polypropylene.

25. The suture of claim 11 containing at least one bioactive substance ionically bonded to the ionomer resin.

26. A surgical mesh fabricated from a biologically acceptable resin blend comprising ionomer resin and nonionic thermoplastic resin.

27. A suture fabricated from a filament obtained by the process comprising melt extruding a biologically acceptable and compatible resin blend comprising ionomer resin and nonionic thermoplastic resin to provide a monofilament, cooling the monofiliment, stretching the cooled monofilament and annealing the stretched monofilament.

28. A suture fabricated from a filament obtained by the process of claim 27 wherein extruding is carried out at from about 180°

to about 250°

C., stretching is carried out from about 60 to about 180°

C. at a stretch ratio of from about 3 to about 8 and annealing is carried out at from about 60 to about 160°

C. with recovery to within about 80 to about 97 percent.

29. A suture fabricated from a filament obtained by the process of claim 27 wherein the blend contains from about 1 to about 40 parts by weight of ionomer resin, the ionomer resin is based on copolymer of an alpha olefin and an ethylenically unsaturated carboxylic acid and the nonionic thermoplastic resin is an isotactic polypropylene, extruding is carried out at from about 190 to about 230°

C., stretching is carried out from about 80 to about 120°

C. at a stretch ratio of from about 5 to about 7 and annealing is carried out at from about 100 to about 150°

C. with recovery to within about 85 to about 95 percent.

30. The suture of claim 27 containing at least one bioactive substance ionically bonded to the ionomer resin.

31. A process of closing a wound comprising:

providing a suture fabricated from a biologically acceptable resin blend comprising ionomer resin an nonionic thermoplastic resin; and

suturing said wound closed with said suture.

32. A process as in claim 31 wherein the suture contains at least one bioactive substance ionically bonded to the ionomer resin.

33. A process of hernia repair comprising:

providing a surgical mesh fabricated from a biologically acceptable resin blend comprising ionomer resin and nonionic thermoplastic resin; and

employing said mesh in repairing a hernia.