Cardiac pacemaker with hysteresis behavior

• US 5,284,491 A
• Filed: 02/27/1992
• Issued: 02/08/1994
• Est. Priority Date: 02/27/1992
• Status: Expired

• Current Assignee: Medtronic Incorporated (Medtronic Plc)
• Original Assignee: Medtronic Incorporated (Medtronic Plc)
• Inventors: Sutton, Richard, Bourgeois, Ivan
• Primary Examiner(s): Cohen, Lee S.
• Assistant Examiner(s): Parker, Marianne
• Application Number:
  US07/842,818
• Time in Patent Office: 712 Days
• Field of Search: 128/419 PG
• US Class Current: 607/17
• CPC Class Codes: A61N 1/365 controlled by a physiological parameter, e.g. heart potential evoked response A61N1/371

Abstract

A pacemaker having a hysteresis feature which permits intrinsic heart activity, controlled by the sinus node to resume optimally after pacing. The pacemaker has a programmable lower rate and upper rate, a programmable lower hysteresis rate (LRH) corresponding to a lower rate hysteresis interval (LRHI), and a programmable rate (IR) intermediate an upper pacing rate (UR) and a lower pacing rate (LR). A microprocessor measures the average rate of change M_AVG in the intervals between consecutive ventricular depolarizations, and compares the last intrinsic escape interval RR_N to the lower rate hysteresis interval (LRHI).

If the last intrinsic escape interval RR_N is longer than the lower rate hysteresis interval (LRHI), and if the value of M_AVG is greater than a first preselected value SL₁ but less than a second preselected value SL₂, the pacemaker stimulates at the lower rate hysteresis (LRH) and thereafter gradually increases the pacing rate up to the intermediate rate (IR). A time counter maintains a continuous pacing at the intermediate rate (IR) for a predefined period of time, and the pacing rate is gradually decreased toward the lower pacing rate (LR).

Claims

1. In a pacemaker having a programmable lower rate and upper rate, a programmable lower rate hysteresis (LRH) corresponding to a lower rate hysteresis interval (LRHI), and a programmable intermediate pacing rate (IR) the improvement comprising:

A. means for measuring rate of change M_AVG of successive cardiac intrinsic escape intervals;

B. means for comparing M_AVG to a first predefined limit SL₁ ;

C. means for comparing the last intrinsic escape interval to the lower rate hysteresis interval (LRHI); and

D. means for stimulating a heart at the lower rate hysteresis (LRH) and for gradually incrementing a pacing rate until the pacing ratio reaches the intermediate pacing rate (IR) if the last intrinsic escape interval is longer than the lower rate hysteresis interval (LRHI) and if said M_AVG is greater than SL₁.

2. The pacemaker according to claim 1 further comprising:

A. time counter means for maintaining continuous pacing at the intermediate rate (IR) for a predefined period of time; and

B. means for allowing gradual decay of the pacing rate after said selected period of time has lapsed.

3. The pacemaker according to claim 2, wherein said selected programmable time is set equal to five minutes.

4. The pacemaker according to claim 1, wherein said means for measuring the rate of change M_AVG comprising:

A. means for measuring intervals between two successive ventricular depolarizations (RR intervals); and

B. means for averaging the rate of change M_AVG of said successive RR intervals.

5. The pacemaker according to claim 4, wherein said means for averaging the rate of change of said RR intervals comprises:

A. means for calculating a difference D between two successive RR intervals;

B. means for comparing said difference D to a predetermined reference value;

C. means for storing those values of D which are greater than said reference value;

D. means for calculating a sum M of N stored values of D, wherein N is a predetermined positive integer; and

E. means for setting M_AVG equal to M/N.

6. The pacemaker according to claim 5, wherein said means for averaging M_AVG comprising means for averaging the values of D greater than said reference value over a predefined period of time.

7. The pacemaker according to claim 6, wherein said reference value is zero, and wherein only positive values of D are stored and added.

8. The pacemaker according to claim 5, wherein N is set equal to six beats.

9. The pacemaker according to claim 4, further including means for comparing M_AVG to a second predetermined limit SL₂ wherein SL₂ has a value greater than that of SL₁.

10. The pacemaker according to claim 9, wherein said means for stimulating gradually increments the pacing rate until the pacing rate reaches the intermediate pacing rate (IR), if the last intrinsic escape interval RR_N is longer than LRHI, and if M_AVG is greater than or equal to SL₁ but less than or equal to SL₂.

11. The pacemaker according to claim 9, further comprising means for inhibiting stimulation if M_AVG is greater than SL₂, and if the RR_N interval is less than or equal to LRHI.

12. The pacemaker according to claim 11, further comprising means for stimulating at the lower rate if M_AVG is greater than SL₂, and if the RRN interval will be longer than LRHI.

13. The pacemaker according to claim 11, further comprising:

A. means for inhibiting stimulation if M_AVG is greater than SL₂, and if the RR_N interval is less than or equal to LRH; and

B. means for stimulating at the lower rate if M_AVG is greater than SL₂, and if the RR_N interval will be longer than LRHI.

14. The pacemaker according to claim 4, further including means for inhibiting stimulation if M_AVG is less than SL₁, and if the last intrinsic escape interval RR_N is less than or equal to LRHI.

15. The pacemaker according to claim 14, further comprising means for stimulating at the lower rate if M_AVG is less than SL₁, and if the RR_N interval will be greater than LRHI.

16. A method for pacing with a pacemaker having a programmable lower rate and upper rate, a programmable lower hysteresis rate (LRH) corresponding to a lower rate hysteresis interval (LRHI), and a programmable intermediate pacing rate (IR), the pacing method comprising the steps of:

A. measuring a rate of change of M_AVG of successive intrinsic escape intervals;

B. comparing M_AVG to a first predetermined limit SL₁ ;

C. comparing a last intrinsic escape interval RR_N to the lower rate hysteresis interval (LRHI); and

D. stimulating at the lower rate hysteresis (LRH) and gradually incrementing a pacing rate until it reaches the intermediate pacing rate (IR) if the RR_N interval will be longer than the lower rate hysteresis interval (LRHI) and if said M_AVG is greater than SL₁.

17. The pacing method according to claim 16 further comprising the steps of:

A. maintaining continuous pacing at the intermediate rate (IR) for a predefined period of time; and

B. allowing gradual decay of the pacing rate after said selected period of time has lapsed.

18. The pacing method according to claim 17, wherein, said step of measuring the rate of change M_AVG comprises:

A. measuring intervals between two successive ventricular depolarizations (RR intervals); and

B. averaging the rate of change M_AVG of said successive RR intervals;

19. The pacing method according to claim 18, wherein said step of averaging the rate of change of said RR intervals comprises:

A. calculating a difference D between two successive RR intervals;

B. comparing the difference D to a predetermined reference value;

C. storing those values of D which are greater than said reference value;

D. calculating a sum M of N stored values of D, wherein N is a predetermined positive integer; and

E. setting M_AVG equal to M/N.

20. The pacing method according to claim 19, further comprising the step comparing M_AVG to a second predetermined limit SL₂, wherein SL₂ has a value greater than that of SL₁.

21. The pacing method according to claim 20, wherein said step of stimulating comprises gradually incrementing the pacing rate until it reaches the intermediate pacing rate (IR), if the RRN interval will be longer than LRHI, and if M_AVG is greater than or equal to SL₁ but less than or equal to SL₂.

22. The pacing method according to claim 18, further comprises:

A. the step of inhibiting stimulation if M_AVG is less than SL₁, and if the last sensed RR interval is less than or equal to LRHI;

B. the step of stimulating at the lower rate if M_AVG is less than SL₁, and if the RR_N interval will be longer than LRHI;

C. the step of inhibiting stimulation if M_AVG is greater than SL₂, and if the RR_N interval is less than or equal to LRHI; and

D. the step of stimulating at the lower rate if M_AVG is greater than SL₂, and if the RR_N interval will be longer than LRHI.