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Method of encapsulating cells in a tubular extrudate

  • US 5,284,761 A
  • Filed: 02/26/1992
  • Issued: 02/08/1994
  • Est. Priority Date: 11/17/1987
  • Status: Expired due to Term
First Claim
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1. A method of encapsulating viable cells comprising(i) co-extruding an aqueous cell suspension and a polymeric solution through a common extrusion port having at least two concentric bores to form a tubular extrudate having a polymeric outer coating which encapsulates said cell suspension, wherein said cell suspension is extruded though an inner bore and said polymeric solution is extruded though an outer bore and a pressure differential is maintained between said cell suspension and said polymeric solution during co-extrusion to impede solvent diffusion from said polymeric solution into said cell suspension and said polymeric solution and said cell suspension are chosen so that coagulation of said polymeric solution occurs as the polymeric solution and cell suspension are extruded through the extrusion port;

  • and(ii) sealing said tubular extrudate to form at least one isolated tubular cell compartment.

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