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Renin inhibitors

  • US 5,284,849 A
  • Filed: 08/14/1992
  • Issued: 02/08/1994
  • Est. Priority Date: 05/11/1990
  • Status: Expired due to Fees
First Claim
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1. A compound of the formula:

  • ##STR9## wherein R1 is 4-piperazinyl, 1-methyl-4-piperazinyl, 1-methyl-1-oxo-4-piperazinyl, 2-oxo-4piperazinyl or 1-methyl-4-homopiperazinyl;

    R2 is benzyl, 2-phenylethyl, 1-naphthylmethyl or 2-naphthylmethyl;

    R3 is 4-thiazolyl, 2-amino-4-thiazolyl, 2-thiazolyl, 5-thiazolyl, 1-pyrazolyl, 3-pyrazolyl or 1-imidazolyl;

    R4 is isobutyl or cyclopropyl;

    R5 is hydrogen or loweralkyl; and

    X is CH2 ;

    or a pharmaceutically acceptable salt, ester or prodrug thereof.

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