Affinity peptides
First Claim
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1. A fusion protein comprising a biologically active polypeptide or protein linked by its amino- and/or carboxyl-terminus to one or two affinity peptides, which affinity peptides have the formula
wherein R1 is hydrogen or a peptide chain formed from about 1 to about 30 amino acids; and
R2 is Q, Q-Ile-Glu-Gly-Arg- or Q-Asp-Asp-Asp-Asp-Lys, where Q is a peptide bond or a peptide chain formed from about 1 to about 30 amino acids.
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Abstract
Fusion proteins and a process for their purification by means of metal chelate affinity chromatography on NTA resins are provided by this invention.
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Citations
10 Claims
- 1. A fusion protein comprising a biologically active polypeptide or protein linked by its amino- and/or carboxyl-terminus to one or two affinity peptides, which affinity peptides have the formula
- space="preserve" listing-type="equation">R.sup.1 --(His).sub.2-6 --R.sup.2,
wherein R1 is hydrogen or a peptide chain formed from about 1 to about 30 amino acids; and
R2 is Q, Q-Ile-Glu-Gly-Arg- or Q-Asp-Asp-Asp-Asp-Lys, where Q is a peptide bond or a peptide chain formed from about 1 to about 30 amino acids.- View Dependent Claims (2, 3, 4, 5, 6, 7, 8)
- 9. An affinity peptide of formula
- space="preserve" listing-type="equation">R.sup.1 --(His).sub.2-6 --R.sup.2,
wherein R1 is hydrogen or a peptide chain formed from about 1 to about 30 amino acids; and
R2 is Q, Q-Ile-Glu-Gly-Arg- or Q-Asp-Asp-Asp-Asp-Lys-, where Q is a peptide bond or a peptide chain formed from about 1 to about 30 amino acids.- View Dependent Claims (10)
Specification