Growth promoters for animals

• US 5,288,496 A
• Filed: 05/15/1990
• Issued: 02/22/1994
• Est. Priority Date: 05/15/1990
• Status: Expired due to Fees

• Current Assignee: Alkermes Controlled Therapeutics Inc. II (Alkermes plc)
• Original Assignee: Stolle Research & Development Corporation
• Inventors: Lewis, Danny H.
• Primary Examiner(s): Phelan, Gabrielle
• Application Number:
  US07/523,249
• Time in Patent Office: 1,379 Days
• Field of Search: 424/426, 424/425, 424/424, 424/422, 424/486, 604/891.1, 604/892.1
• US Class Current: 424/426
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/365 Lactones
• CPC Class Codes: A61K 31/565 not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
• CPC Class Codes: A61K 31/568 substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
• CPC Class Codes: A61K 9/1647 Polyesters, e.g. poly(lactide-co-glycolide)
• CPC Class Codes: A61K 9/5084 Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs tablets containing such a mixture A61K9/2077
• CPC Class Codes: Y02A 50/30 Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

A delivery for providing growth promoters to food animals is provided and a method of promoting growth in food animals using such delivery systems is described.

Claims

1. A method of promoting growth in animals wherein said method comprises administration, in amounts sufficient to promote growth in said animals, of an injectable, biodegradable, composition comprising microparticles, wherein said microparticles comprise a steroid growth promoter within a polymeric matrix, and wherein the polymeric matrix of said microparticle composition is selected from the group consisting of poly-d,l-lactic acid, poly-L-lactic acid, polyglycolic acid, copolymers of mixed d,l-lactic acid and glycolic acid, copolymers of L-lactic acid and glycolic acid, copolyoxalates, polycaprolactone, poly(lactic acid-caprolactone), poly(glycolic acid-caprolactone), casein, albumin, and waxes.

8. The method of any of claims 1-5, wherein said microparticles are administered by subcutaneous injection.

9. The method of any of claims 1-5, wherein the growth promoter is selected from the group consisting of estradiol benzoate, trenbolone acetate, zeranol and 17β

-estradiol.

10. The method of claim 9, wherein said growth promoter is estradiol benzoate.

11. The method of claim 9, wherein said growth promoter is trenbolone acetate.

12. The method of claim 9, wherein said growth promoter is zeranol.

13. The method of claim 9, wherein said growth promoter is 17β

-estradiol.

2. A method of promoting growth in animals wherein said method comprises administration, in amounts sufficient to promote growth in said animals, of an injectable, biodegradable, composition comprising microparticles, wherein said microparticles comprise a steroid growth promoter within a polymeric matrix, and wherein said microparticles are loaded with 1 to 75 wt.% of said growth promoter based on the weight of said polymeric matrix.

3. A method of promoting growth in animals wherein said method comprises administration, in amounts sufficient to promote growth in said animals, of an injectable, biodegradable, composition comprising microparticles, wherein said microparticles comprise a steroid growth promoter within a polymeric matrix, and wherein said microparticles range in size from 1 to 250 microns.

4. A method of promoting growth in animals wherein said method comprises administration, in amounts sufficient to promote growth in said animals, of an injectable, biodegradable, composition comprising microparticles, wherein said microparticles comprise a steroid growth promoter within a polymeric matrix, wherein said microparticle composition is in a liquid injection vehicle, and wherein said liquid injection vehicle is selected from the group consisting of physiological saline solution, and an aqueous solution of carboxymethyl cellulose with a surfactant.

5. A method of promoting growth in animals wherein said method comprises administration, in amounts sufficient to promote growth in said animals, of an injectable, biodegradable, composition comprising microparticles, wherein said microparticles comprise a steroid growth promoter within a polymeric matrix, and wherein said microparticles are administered by intra-muscular injection.

6. A method of promoting growth in animals wherein said method comprises administration, in amounts sufficient to promote growth in said animals, of an injectable, biodegradable, composition comprising microparticles, wherein said microparticles comprise a steroid growth promoter within a polymeric matrix, and wherein a combination of two or more separately microencapsulated growth promoters is administered.

14. The method of claim 6 wherein said growth promoters are selected from the group consisting of 17β

-estradiol, estradiol benzoate, trenbolone acetate, zeranol and testosterone.

15. The method of claim 14 wherein said combination comprises any two of the growth promoters of claim 14.

16. The method of claim 15 wherein said combination comprises zeranol and estradiol benzoate.

17. The method of claim 15 wherein said combination comprises zeranol and 17β

-estradiol.

18. The method of claim 15 wherein said combination comprises zeranol and testosterone.

19. The method of claim 15 wherein said combination comprises trenbolone acetate and estradiol benzoate.

20. The method of claim 15 wherein said combination comprises trenbolone acetate and 17β

-estradiol.

21. The method of claim 15 wherein said combination comprises 17β

-estradiol and estradiol benzoate.

22. The method of claim 15 wherein said combination comprises 17β

-estradiol and testosterone.

23. The method of claim 15 wherein said combination comprises estradiol benzoate and testosterone.

24. The method of claim 15 wherein said combination comprise testosterone and trenbolone acetate.

25. The method of claim 15 wherein said combination comprises zeranol and trenbolone acetate.

7. A method of promoting growth in animals wherein said method comprises administration, in amounts sufficient to promote growth in said animals, of an injectable, biodegradable, composition comprising microparticles, wherein said microparticles comprise a steroid growth promoter within a polymeric matrix, and wherein two or more growth promoters are incorporated within a single microparticle matrix.

26. The method of claim 7 wherein said growth promoters are selected from the group consisting of zeranol, trenbolone acetate, estradiol benzoate, 17β

-estradiol and testosterone.

27. The method of claim 26 wherein said combination comprise any two of the growth promoters of claim 26.

28. The method of claim 27 wherein said combination comprises zeranol and estradiol benzoate.

29. The method of claim 27 wherein said combination comprises zeranol and 17β

-estradiol.

30. The method of claim 27 wherein said combination comprise zeranol and testosterone.

31. The method of claim 27 wherein said combination comprises trenbolone acetate and estradiol benzoate.

32. The method of claim 27 wherein said combination comprises trenbolone acetate and 17β

-estradiol.

33. The method of claim 27 wherein said combination comprises 17β

-estradiol and estradiol benzoate.

34. The method of claim 27 wherein said combination comprises 17β

-estradiol and testosterone.

35. The method of claim 27 wherein said combination comprises estradiol benzoate and testosterone.

36. The method of claim 27 wherein said combination comrpises testosterone and trenbolone acetate.

37. The method of claim 27 wherein said combination comprises zeranol and trenbolone acetate.