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Solid phase and combinatorial synthesis of benzodiazepine compounds on a solid support

  • US 5,288,514 A
  • Filed: 09/14/1992
  • Issued: 02/22/1994
  • Est. Priority Date: 09/14/1992
  • Status: Expired due to Term
First Claim
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1. A method of making a plurality of benzodiazepines on a substrate comprising the steps of:

  • coupling substituted amino benzophenones to a substrate, said substituted amino benzophenones comprising protecting groups;

    removing said protecting groups from said amino benzophenones to form amino benzophenones having amino active sites;

    coupling a plurality of amino acid derivatives to said amino active sites; and

    cyclizing molecules resulting from the step of coupling said plurality of amino acid derivatives, whereby a plurality of benzodiazepines are formed on said substrate.

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