Adaptive scheduling system and method for operating a biological sample analyzer with variable rinsing

• US 5,289,385 A
• Filed: 06/03/1991
• Issued: 02/22/1994
• Est. Priority Date: 06/03/1991
• Status: Expired due to Fees

• Current Assignee: Abbott Laboratories Incorporated
• Original Assignee: Abbott Laboratories Incorporated
• Inventors: Grandone, Cass J.
• Primary Examiner(s): Harvey, Jack B.
• Assistant Examiner(s): PEESO, THOMAS R
• Application Number:
  US07/710,195
• Time in Patent Office: 995 Days
• Field of Search: 364/497, 364/496, 73/863, 73/863.01, 73/863.11, 422/67, 422/65, 436/34, 436/50, 436/47, 436/48
• US Class Current: 702/19
• CPC Class Codes: G01N 2035/00752 bar codes
• CPC Class Codes: G01N 35/00594 Quality control, including calibration or testing of components of the analyser
• CPC Class Codes: G01N 35/00712 Automatic status testing, e.g. at start-up or periodic
• CPC Class Codes: G01N 35/00732 Identification of carriers, materials or components in automatic analysers
• CPC Class Codes: G01N 35/0092 Scheduling
• CPC Class Codes: G01N 35/025 having a carousel or turntable for reaction cells or cuvettes
• CPC Class Codes: G01N 35/1004 Cleaning sample transfer devices

Abstract

An improved biological sample analyzer for conducting assays of samples loaded therein, and a method and system for operation thereof, that schedules operations by instrument systems on each biological sample and schedules a conditional cleaning operation prior to a scheduled instrument system operation. The analyzer conducts the assays of the biological samples by performing the scheduled instrument system operations and performs a cleaning operation prior to any scheduled instrument system operation conditioned upon the instrument system operation scheduled prior to the cleaning operation. The biological analyzer can perform a warming operation prior to a scheduled instrument system operation determined upon the lapse of time between the scheduled instrument system operation and the instrument system operation scheduled prior thereto.

Claims

1. An improved biological sample analyzer for conducting assays of samples loaded therein and which includes instrument systems for performing operations on each biological sample and a scheduling means for scheduling the operations of the instrument systems, the improvement comprising:

(a) means for scheduling an adaptive cleaning operation prior to any scheduled instrument system operation; and

(b) means for conducting the assays of the biological samples by performing the scheduled instrument system operations and performing a cleaning operation prior to any scheduled instrument system operation, said cleaning operation determined by the instrument system operation scheduled prior to said cleaning operation.

2. The improved biological analyzer of claim 1 in which the means for conducting an assay further comprises:

means for conducting first and second assays of the biological samples wherein said first assay and said second assay are different assays.

3. The improved biological analyzer of claim 2 in which the means for scheduling a cleaning operation prior to performing a scheduled system operation further comprises:

means for performing a first cleaning operation upon the condition that the instrument system operations immediately preceding said cleaning operation are of a first assay type, and

means for performing a second cleaning operation upon the condition that the instrument system operations immediately preceding said cleaning operation are of a second assay type.

4. The improved biological sample analyzer of claim 1 further comprising:

(a) means for scheduling a warming operation prior to an instrument system operation; and

(b) means for conducting the assays of the biological samples by performing the scheduled instrument system operations and performing a warming operation prior to a scheduled instrument system operation determined upon a scheduled lapse of time between the scheduled instrument system operation and the instrument system operation scheduled prior thereto.

5. A biological sample analyzer for conducting assays of biological samples loaded therein comprising:

(a) means for scheduling operations by instrument systems on each biological sample;

(b) means for scheduling a conditional cleaning operation prior to any instrument system operation; and

(c) means for conducting the assays of the biological samples by performing the scheduled instrument system operations and performing a cleaning operation prior to any scheduled instrument system operation, said cleaning operation conditioned upon the instrument system operation scheduled prior to said cleaning operation.

6. The biological analyzer of claim 5 further comprising:

means for conducting first and second assays of the biological samples wherein said first assay and said second assay are different assays.

7. The biological analyzer of claim 6 in which the means for scheduling a conditional cleaning operation prior to performing a cleaning operation further comprises:

means for performing a first cleaning operation upon the condition that the instrument system operations immediately preceding said cleaning operation are of a first assay type, and

means for performing a second cleaning operation upon the condition that the instrument system operations immediately preceding said cleaning operation are of a second assay type.

8. The improved biological sample analyzer of claim 5 further comprising:

means for scheduling a warming operation prior to an instrument system operation; and

further in which the means for conducting the assays of the biological samples by performing the scheduled instrument system operations further comprises;

means for performing a warming operation prior to a scheduled instrument system operation determined upon a scheduled lapse of time between the scheduled instrument system operation and the instrument system operation scheduled prior thereto.

9. An improved method of operating a biological sample analyzer for conducting assays of samples loaded and in which operations by instrument systems are scheduled to be performed on each biological sample, the improvement comprising the steps of:

(a) scheduling a conditional cleaning operation prior to any scheduled instrument system operation; and

(b) conducting the assays of the biological samples by performing the scheduled instrument system operations and performing a cleaning operation prior to any scheduled instrument system operation, said cleaning operation determined by the instrument system operation scheduled prior to said cleaning operation.

10. The improved method of claim 9 in which the step of conducting an assay further comprises:

conducting first and second assays of the biological samples wherein said first assay and said second assay are different assays.

11. The improved method of operating a biological sample analyzer of claim 9 in which the step of scheduling operations by instrument systems further comprises the steps of:

(a) developing time blocks for each sample for conducting operations to be performed by instrument systems for each specimen sample to perform the assay of said each sample; and

(b) developing a schedule of the time blocks to be performed by the analyzer instrument systems on the samples;

and in which the step of scheduling a conditional cleaning operation is characterized as further comprising the step of;

scheduling a cleaning operation to be performed by an instrument system at a transition between time blocks from the developed schedule of time blocks.

12. The improved method of claim 11 in which the step of scheduling a cleaning operation is based upon the sequence of time blocks schedule.

13. The improved method of claim 12 in which the step of scheduling a cleaning operation is performed after all the time blocks of all the samples have been scheduled.

14. The improved method of claim 11 in which the step of performing a cleaning operation further comprises:

performing a first cleaning operation before a time block for a sample upon the condition that the time block is preceded by a time block of a first assay type, and performing a second cleaning operation before the time block for said sample conditioned upon the time block being preceded by a time block of a second assay type.

15. The improved method of claim 14 in which the step of performing cleaning operation is further characterized wherein the first assay type is the same assay type as being performed on said sample and the second assay type is an assay different from the assay type being performed on said sample.

16. The improved method of operating a biological sample analyzer of claim 9 for conducting assays of samples loaded therein further comprising the step of:

scheduling a warming operation prior to any instrument system operation; and

in which the step of conducting the assays of the biological samples by performing the scheduled instrument system operations is further characterized by the step of;

performing a warming operation prior to a scheduled instrument system operation determined upon the lapse of time between the scheduled instrument system operation and the instrument system operation scheduled prior thereto.

17. A method of operating a biological sample analyzer for conducting assays of biological samples loaded therein comprising the steps of:

(a) scheduling operations by instrument systems on each biological sample;

(b) scheduling a conditional cleaning operation prior to any instrument system operation; and

(c) conducting the assays of the biological samples by

(1) performing the scheduled instrument system operations, and

(2) performing a cleaning operation prior to any scheduled instrument system operation, said cleaning operation conditioned upon the instrument system operation scheduled prior to said cleaning operation.

18. The method of claim 17 in which the step of conducting the assays further comprises:

conducting first and second assays of the biological samples wherein said first assay and said second assay are different assays.

19. The method of claim 17 in which the step of scheduling operations by instrument systems is characterized as further comprising the steps of:

(a) developing time blocks for each sample for conducting operations to be performed by instrument systems for each specimen sample to perform the assay of the sample; and

(b) developing a schedule of the time blocks to be performed by the analyzer instrument systems on the samples, said schedule including a sequence of time blocks;

and in which the step of scheduling a conditional cleaning operation is characterized as further comprising the step of;

scheduling a cleaning operation to be performed by an instrument system at a transition between time blocks from the developed schedule of time blocks.

20. The method of claim 19 in which the step of scheduling a cleaning operation is based upon the sequence of time blocks scheduled.

21. The method of claim 20 in which the step of scheduling a cleaning operation is performed after all the time blocks of all the samples have been scheduled.

22. The method of claim 21 in which the step of performing a cleaning operation further comprises:

performing a first cleaning operation before a time block for a sample upon the condition that the time block is preceded by a time block of a first assay type, and performing a second cleaning operation before the time block for said sample upon the condition that the time block is preceded by a time block of a second assay type.

23. The method of claim 22 in which the step of performing a cleaning operation further comprises:

performing a first cleaning operation before a time block for a sample upon the condition that the time block is immediately preceded by a time block of a first assay type, and performing a second cleaning operation before the time block for said sample upon the condition that the time block is immediately preceded by a time block of a second assay type.

24. The method of claim 23 in which the step of performing cleaning operation is further characterized wherein the first assay type is the same assay type as being performed on said sample and the second assay type is an assay different from the assay type being performed on said sample.

25. The method of claim 24 in which the step of performing a cleaning operation is further characterized as rinsing a pipette probe of the biological analyzer.

26. The method of operating a biological sample analyzer of claim 17 further comprising the step of:

scheduling a warming operation prior to any instrument system operation; and

in which the step of conducting the assays of the biological samples by performing the scheduled instrument system operations is further characterized by the step of;

performing a warming operation prior to a scheduled instrument system operation determined upon the lapse of time between the scheduled instrument system operation and the instrument system operation scheduled prior thereto.

27. An improved method of operating a biological sample analyzer for conducting assays of biological samples loaded therein comprising the steps of:

(a) scheduling operations by instrument systems on each biological sample; and

(b) conducting the assays of the biological samples by performing the scheduled instrument system operations and performing a warming operation prior to a scheduled instrument system operation, said warming operation determined upon the lapse of time between the scheduled instrument system operation and the instrument system operation scheduled prior thereto.

28. An improved biological sample analyzer for conducting assays of biological samples loaded therein comprising:

(a) means for scheduling operations by instrument systems on each biological sample; and

(b) means for conducting the assays of the biological samples by performing the scheduled instrument system operations and performing a warming operation prior to a scheduled instrument system operation, said warming operation determined upon a lapse of time between the scheduled instrument system operation and the instrument system operation scheduled prior thereto.

29. The improved method of claim 28 in which the means for conducting an assay further comprises:

means for conducting first and second assays of the biological samples wherein said first assay and said second assay are different assays.