Surgical implant and method for controlled release of chemotherapeutic agents

• US 5,290,271 A
• Filed: 07/29/1993
• Issued: 03/01/1994
• Est. Priority Date: 05/14/1990
• Status: Expired due to Term

• Current Assignee: Dermagenesis, LLC
• Original Assignee: Gary R. Jernberg
• Inventors: Jernberg, Gary R.
• Primary Examiner(s): Rosenbaum, C. Fred
• Assistant Examiner(s): STRIGHT, RONALD K
• Application Number:
  US08/099,265
• Time in Patent Office: 215 Days
• Field of Search: 623/11, 623/13, 623/16, 604/890.1, 604/891.1, 424/469-473
• US Class Current: 604/891.1
• CPC Class Codes: A61F 2/06 Blood vessels
• CPC Class Codes: A61F 2/08 Muscles; Tendons; Ligaments sutures A61B17/04
• CPC Class Codes: A61F 2210/0004 bioabsorbable
• CPC Class Codes: A61F 2250/0067 Means for introducing or releasing pharmaceutical products into the body
• CPC Class Codes: A61K 9/0024 Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue compositions for intravenous administration, normal injectable solutions or dispersions for, e.g. subcutaneous administration A61K9/0019; brain implants A61K9/0085; (coated) prostheses, catheters or stents A61L
• CPC Class Codes: A61L 2300/404 Biocides, antimicrobial agents, antiseptic agents
• CPC Class Codes: A61L 2300/406 Antibiotics
• CPC Class Codes: A61L 2300/41 Anti-inflammatory agents, e.g. NSAIDs
• CPC Class Codes: A61L 2300/42 Anti-thrombotic agents, anticoagulants, anti-platelet agents
• CPC Class Codes: A61L 2300/602 Type of release, e.g. controlled, sustained, slow
• CPC Class Codes: A61L 2300/622 Microcapsules
• CPC Class Codes: A61L 27/54 Biologically active materials, e.g. therapeutic substances A61L27/227 takes precedence

Abstract

An implant and method is disclosed using microparticles to provide a controlled, sustained release, and improved cellular uptake, of chemotherapeutic agents.

Claims

1. A surgical implant comprising a porous matrix, said matrix further containing time-release microshapes encapsulating at least one chemotherapeutic agent incorporated into said porous matrix, wherein said time-release microshapes will begin to release said at least one chemotherapeutic agent at a localized treatment site upon surgical implantation of said implant, said implant further containing means for improving the cellular uptake of said at least one chemotherapeutic agent at the localized treatment site upon surgical implantation of said implant, said means comprising at least one carrier agent incorporated into the matrix of said implant, said implant selected from the group consisting of a vascular graft, heart valve leaflet, ligament prosthesis, tendon prosthesis and urethral prosthesis.

2. The surgical implant of claim 1 wherein the carrier agent is hyaluronic acid or a derivative thereof.

3. The surgical implant of claim 1 wherein the carrier agent is encapsulated in a time-release microshape.

4. The surgical implant of claim 1 wherein the carrier agent is mixed with the at least one chemotherapeutic agent and encapsulated in said time-release microshape prior to incorporating said time-release microshapes into said matrix of said implant.

5. The implant of claim 1 being constructed of a biodegradable, resorbable material.

6. The implant of claim 5, wherein said biodegradable, resorbable material is cross-linked collagen or an ester of hyaluronic acid.