Lubricious hydrogel coatings

• US 5,290,585 A
• Filed: 06/10/1992
• Issued: 03/01/1994
• Est. Priority Date: 11/01/1990
• Status: Expired due to Term

• Current Assignee: Medtronic Ave Incorporated (Medtronic Plc)
• Original Assignee: C.R. Bard, Inc. (Becton, Dickinson & Co)
• Inventors: Elton, Richard K.
• Primary Examiner(s): Beck, Shrive
• Assistant Examiner(s): DUDASH, DIANA L
• Application Number:
  US07/896,284
• Time in Patent Office: 629 Days
• Field of Search: 427/2, 427/385.5, 604/264, 604/265
• US Class Current: 427/2.3
• CPC Class Codes: A61L 2400/10 Materials for lubricating medical devices
• CPC Class Codes: A61L 29/085 Macromolecular materials
• CPC Class Codes: A61L 29/14 Materials characterised by their function or physical properties , e.g. lubricating compositions
• CPC Class Codes: C08L 2666/10 Homopolymers or copolymers according to C08L39/00 - C08L49/00; Derivatives thereof
• CPC Class Codes: C08L 2666/14 Macromolecular compounds according to C08L59/00 - C08L87/00; Derivatives thereof
• CPC Class Codes: C08L 35/06 Copolymers with vinyl aromatic monomers
• CPC Class Codes: C08L 75/04 Polyurethanes
• CPC Class Codes: C09D 139/06 Homopolymers or copolymers of N-vinyl-pyrrolidones
• CPC Class Codes: C09D 175/04 Polyurethanes
• CPC Class Codes: Y10T 428/31507 Of polycarbonate
• CPC Class Codes: Y10T 428/31551 Of polyamidoester [polyurethane, polyisocyanate, polycarbamate, etc.]
• CPC Class Codes: Y10T 428/31554 Next to second layer of polyamidoester
• CPC Class Codes: Y10T 428/31562 Next to polyamide [nylon, etc.]
• CPC Class Codes: Y10T 428/31565 Next to polyester [polyethylene terephthalate, etc.]
• CPC Class Codes: Y10T 428/31569 Next to natural rubber
• CPC Class Codes: Y10T 428/31587 Hydrocarbon polymer [polyethylene, polybutadiene, etc.]

Abstract

A flexible, lubricious organic coating is formed by applying a mixture of an isocyanate, a polyol, polyvinylpyrrolidone (PVP), and carrier liquid to a surface to be coated. The carrier liquid is removed and the mixture reacted to form a lubricious, flexible coating, particularly suitable for use as a protective lubricious coating on medical devices introduced into the body. The coating exhibits a significantly reduced coefficient of friction when exposed to water or aqueous solutions.

Claims

1. A method of preparing a hydrophilic lubricious, organic coating on an organic substrate to be coated;

said method comprising forming an organic coating mixture of an isocyanate, a polyol and a polyvinylpyrrolidone in a carrier liquid diluent, said isocyanate containing at least two NCO groups per molecule and the polyol having at least two hydroxy groups per molecule, the sum of the average NCO functionality and the average hydroxy functionality exceeding 4, applying said mixture to the substrate, removing at least a portion of said carrier liquid diluent, and then curing to form a coating of a cross-linked polyurethane and a polyvinylpyrrolidone the ratio by weight of the polyurethane to polyvinylpyrrolidone being from about 0.05 to 3.0.

2. A method of preparing hydrophilic, lubricious organic coating comprising,

forming a reaction mixture containing an isocyanate, a polyol and a polyvinylpyrrolidone having a molecular weight in the range of from 50,000 to 2.5 million and a water content of less than 1% (w/w), said isocyanate containing at least two NCO groups per molecule and the polyol having at least two hydroxy groups per molecule, the sum of the average NCO functionality and the average hydroxy functionality exceeding 4,

dissolving said mixture in a solvent to form a solution thereof

applying said solution to an organic substrate to form a coating,

removing said solvent,

and curing said coating to allow said polyol and isocyanate to react to form a coating of a crosslinked polyurethane matrix and a polyvinylpyrrolidone the ratio by weight of the polyurethane to polyvinylpyrrolidone being from about 0.05 to 3.0.

3. A method in accordance with the method of claim 2 wherein said curing is carried out at a temperature of from 70°

F. to 250°

F. for a time period of from 2 minutes to 72 hours.

4. A method in accordance with the method of claim 2 wherein said substrate is a catheter and said coating overlies said catheter.