Lubricious hydrogel coatings
First Claim
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1. A method of preparing a hydrophilic lubricious, organic coating on an organic substrate to be coated;
- said method comprising forming an organic coating mixture of an isocyanate, a polyol and a polyvinylpyrrolidone in a carrier liquid diluent, said isocyanate containing at least two NCO groups per molecule and the polyol having at least two hydroxy groups per molecule, the sum of the average NCO functionality and the average hydroxy functionality exceeding 4, applying said mixture to the substrate, removing at least a portion of said carrier liquid diluent, and then curing to form a coating of a cross-linked polyurethane and a polyvinylpyrrolidone the ratio by weight of the polyurethane to polyvinylpyrrolidone being from about 0.05 to 3.0.
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Abstract
A flexible, lubricious organic coating is formed by applying a mixture of an isocyanate, a polyol, polyvinylpyrrolidone (PVP), and carrier liquid to a surface to be coated. The carrier liquid is removed and the mixture reacted to form a lubricious, flexible coating, particularly suitable for use as a protective lubricious coating on medical devices introduced into the body. The coating exhibits a significantly reduced coefficient of friction when exposed to water or aqueous solutions.
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Citations
4 Claims
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1. A method of preparing a hydrophilic lubricious, organic coating on an organic substrate to be coated;
said method comprising forming an organic coating mixture of an isocyanate, a polyol and a polyvinylpyrrolidone in a carrier liquid diluent, said isocyanate containing at least two NCO groups per molecule and the polyol having at least two hydroxy groups per molecule, the sum of the average NCO functionality and the average hydroxy functionality exceeding 4, applying said mixture to the substrate, removing at least a portion of said carrier liquid diluent, and then curing to form a coating of a cross-linked polyurethane and a polyvinylpyrrolidone the ratio by weight of the polyurethane to polyvinylpyrrolidone being from about 0.05 to 3.0.
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2. A method of preparing hydrophilic, lubricious organic coating comprising,
forming a reaction mixture containing an isocyanate, a polyol and a polyvinylpyrrolidone having a molecular weight in the range of from 50,000 to 2.5 million and a water content of less than 1% (w/w), said isocyanate containing at least two NCO groups per molecule and the polyol having at least two hydroxy groups per molecule, the sum of the average NCO functionality and the average hydroxy functionality exceeding 4, dissolving said mixture in a solvent to form a solution thereof applying said solution to an organic substrate to form a coating, removing said solvent, and curing said coating to allow said polyol and isocyanate to react to form a coating of a crosslinked polyurethane matrix and a polyvinylpyrrolidone the ratio by weight of the polyurethane to polyvinylpyrrolidone being from about 0.05 to 3.0.
Specification