Angiotensin II receptor blocking 2,3,6 substituted quinazolinones

• US 5,290,780 A
• Filed: 01/14/1992
• Issued: 03/01/1994
• Est. Priority Date: 01/30/1991
• Status: Expired due to Term

• Current Assignee: American Colloid Company (Minerals Technologies Incorporated)
• Original Assignee: American Colloid Company (Minerals Technologies Incorporated)
• Inventors: Venkatesan, Aranapakam, Levin, Jeremy I.
• Primary Examiner(s): Shah, Mukund J.
• Assistant Examiner(s): Grumbling, Matthew V.
• Application Number:
  US07/818,721
• Time in Patent Office: 777 Days
• Field of Search: 544/287, 544/284, 544/287, 514/259
• US Class Current: 514/266.23
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
• CPC Class Codes: A61P 9/00 Drugs for disorders of the cardiovascular system
• CPC Class Codes: A61P 9/12 Antihypertensives
• CPC Class Codes: C07D 239/88 Oxygen atoms
• CPC Class Codes: C07D 239/91 with aryl or aralkyl radicals attached in position 2 or 3
• CPC Class Codes: C07D 403/10 linked by a carbon chain containing aromatic rings
• CPC Class Codes: C07F 7/0812 comprising a heterocyclic ring
• CPC Class Codes: C07F 7/1804 Compounds having Si-O-C linkages Si-O-acyl linkages C07F7/1896

Abstract

Novel quinazolinone compounds of the formula: ##STR1## wherein R⁵, R⁶, R⁷, R⁸, R and X are defined in the specification, which have angiotensin II (AII) antagonizing activity, intermediates useful in the preparation of the compounds, methods of producing and using the compounds to alleviate angiotensin induced hypertension and treat congestive heart failure in mammals.

Claims

1. The compound 2-butyl-6-(1-methoxy-1-methylethyl)-3-[[2'"'"'-(1H-tetrazol-5-yl)[1,1'"'"'-biphenyl]-4-yl]methyl]-4(3H)-quinazolinone, sodium salt.

3. A pharmaceutical composition useful for treating angiotensin induced hypertension or congestive heart failure in a mammal comprising a suitable pharmaceutical carrier and an effective amount of a compound of claim 1.

4. A method of treating angiotensin induced hypertension in a mammal comprising administering a compound of claim 1 to said mammal an amount effective to lower angiotensin induced hypertension.

5. A method of treating congestive heart failure in a mammal comprising administering a compound of claim 1 to said mammal in an amount effective to treat congestive heart failure.

2. The compound 2-butyl-6-(1-methoxy-1-methylethyl)-3-[[2'"'"'-(1H-tetrazol-5-yl)[1,1'"'"'-biphenyl]-4-yl]methyl]-4(3H)-quinazolinone.