Apparatus for measuring a blood parameter

• US 5,291,884 A
• Filed: 02/07/1991
• Issued: 03/08/1994
• Est. Priority Date: 02/07/1991
• Status: Expired due to Term

• Current Assignee: Terumo Cardiovascular Systems Corporation (Terumo Corporation)
• Original Assignee: Minnesota Mining and Manufacturing Co (3M Company)
• Inventors: Cavanaugh, Susan, Heinemann, Stan O., Mullin, Paul J.
• Primary Examiner(s): Green, Randall L.
• Assistant Examiner(s): ZUTTARELLI, ANTHONY
• Application Number:
  US07/652,121
• Time in Patent Office: 1,125 Days
• Field of Search: 128/633, 128/634, 128/664, 128/665, 356/40, 356/41
• US Class Current: 600/322
• CPC Class Codes: A61B 5/14535 for measuring haematocrit
• CPC Class Codes: A61B 5/14557 specially adapted to extracorporeal circuits
• CPC Class Codes: A61B 5/1495 Calibrating or testing of in-vivo probes
• CPC Class Codes: G01N 21/3151 using two sources of radiation of different wavelengths G01N21/33 - G01N21/39 take precedence

Abstract

An apparatus for measuring a blood parameter comprising a red light source and an infrared light source for directing light toward a blood-receiving location and a detector, for receiving light from the first and second light sources which has been back scattered by the blood. The intensity of the first light source is adjusted so that the intensity of light at the detector from the first light source remains substantially constant over a range of values of the blood parameter and the intensity of the second light source is adjusted so that the intensity of light at the detector from the second light source is substantially constant over a range of values of the blood parameter. A signal is provided which is related to the intensity of one or both of the light sources and which provides an indication of the blood parameter. A circuit is provided to compensate for errors resulting from the light sources.

Claims

1. An apparatus for measuring a blood parameter comprising:

at least first and second light sources for emitting light having first and second light intensities, respectively, toward a blood-receiving location, the light emitted by said first and second light sources having first and second wavelength characteristics, respectively, said first and second wavelength characteristics being different;

a detector for receiving light from the first and second light sources after interaction with blood at the blood-receiving location;

means for adjusting the intensity of the light emitted by the first light source so that intensity of the light at the detector from the first light source is substantially constant over a range of values of the blood parameter and for adjusting the intensity of the light emitted by the second light source so that intensity of light at the detector from the second light source is substantially constant over a range of values of the blood parameter; and

means for providing a signal which is related to the intensity of at least one of the first and second light sources and which provides an indication of the blood parameter.

2. An apparatus as defined in claim 1 wherein said signal is a function of the first light intensity and the blood parameter is hematocrit.

3. An apparatus as defined in claim 1 wherein said signal is a function of the first light intensity and not of the second light intensity and the blood parameter is hematocrit.

4. An apparatus as defined in claim 1 wherein the signal providing means provides a signal which is a function of the ratio of the first and second light intensities and the blood parameter is oxygen saturation.

5. An apparatus as defined in claim 1 wherein the detector provides a detector signal related to the intensity of the light received at the detector and the intensity adjusting means includes a feedback loop responsive to said detector signal for providing a feedback signal to adjust the intensities of the first and second light sources.

6. An apparatus as defined in claim 5 wherein the first intensity of the light emitted by the first light source is subject to varying for a given feedback signal to the first light source so that the first intensity does not accurately track with the feedback signal and said apparatus includes means for making the first intensity of the light emitted by the first light source track more accurately with said given feedback signal.

7. An apparatus as defined in claim 5 wherein the intensity of the light emitted by the first light source varies with the feedback signal in accordance with a predetermined relationship but is subject to deviating from said predetermined relationship and the apparatus includes means for reducing the deviations from said predetermined relationship.

8. An apparatus as defined in claim 1 including a reference detector for receiving at least some of the light emitted by the first light source and circuit means responsive to intensity of the light received by the reference detector for adjusting the intensity of the light emitted by the first light source.

9. An apparatus as defined in claim 5 including a reference detector for receiving at least some of the light emitted by the first light source and circuit means responsive to intensity of the light received by the reference detector and the feedback signal for adjusting the intensity of the light emitted by the first light source.

10. An apparatus as defined in claim 1 including a flow-through housing for blood defining said blood-receiving location.

11. An apparatus for measuring a blood parameter comprising:

a light source for emitting light having an intensity toward a blood-receiving location;

a detector for receiving light from the light source after the emitted light interacts with the blood at the blood-receiving location;

a feedback loop responsive to intensity of the light received by the detector for providing a feedback signal for adjusting the intensity of the light source so that the intensity of the light received by the detector from the light source is substantially constant over a range of values of the blood parameter;

said emitted light intensity varying with the feedback signal in accordance with a predetermined relationship and being subject to deviating from said relationship;

a reference detector for receiving at least some of the light emitted by the light source and providing a reference detector signal which is related to the intensity of the light it receives;

means responsive to the feedback signal and the reference detector signal for providing a drive signal for energizing the light source to make the emitted light intensity more in accordance with said relationship; and

means responsive to the feedback signal for providing an output signal which provides an indication of the blood parameter.

12. An apparatus as defined in claim 11 wherein said blood parameter is hematocrit.

13. An apparatus as defined in claim 11 wherein the reference detector signal is linearly related to the intensity of the light it receives.

14. An apparatus as defined in claim 11 wherein said relationship is a linear relationship.

15. An apparatus as defined in claim 11 including a flow-through housing for blood defining said blood-receiving location.

16. An apparatus for measuring a blood parameter comprising:

at least first and second light sources for emitting light having first and second light intensities, respectively, toward a blood-receiving location, the light emitted by the first and second light sources having first and second wavelength characteristics, respectively, said first and second wavelength characteristics being different;

a detector for receiving light from the first and second light sources after interaction with blood at the blood-receiving location;

a feedback loop for adjusting the intensity of the light emitted by the first light source so that intensity of the light at the detector from the first light source is substantially constant over a range of values of the blood parameter and for adjusting the intensity of the light emitted by the second light source so that intensity of light at the detector from the second light source is substantially constant over a range of values of the blood parameter; and

a signal processor for providing a signal which is related to the intensity of at least one of the first and second light sources and which provides an indication of the blood parameter.

17. An apparatus for measuring a blood parameter comprising:

a light source for emitting light having an intensity toward a blood-receiving location;

a detector for receiving light from the light source after the emitted light interacts with the blood at the blood-receiving location;

a feedback loop responsive to intensity of the light received by the detector for providing a feedback signal for adjusting the intensity of the light source so that the intensity of the light received by the detector from the light source is substantially constant over a range of values of the blood parameter;

said emitted light intensity varying with the feedback signal in accordance with a predetermined relationship and being subject to deviating from said relationship;

a reference detector for receiving at least some of the light emitted by the light source and providing a reference detector signal which is related to the intensity of the light it receives;

a signal correction network responsive to the feedback signal and the reference detector signal for providing a drive signal for energizing the light source to make the emitted light intensity more in accordance with said relationship; and

a signal processor responsive to the feedback signal for providing an output signal which provides an indication of the blood parameter.