Apparatus for measuring blood flow

• US 5,291,885 A
• Filed: 11/21/1991
• Issued: 03/08/1994
• Est. Priority Date: 11/27/1990
• Status: Expired due to Fees

• Current Assignee: KOWA Company Limited
• Original Assignee: KOWA Company Limited
• Inventors: Ishikawa, Muneharu, Taniji, Ayafumi
• Primary Examiner(s): Green, Randall L.
• Assistant Examiner(s): GUALTIERI, GINA
• Application Number:
  US07/795,814
• Time in Patent Office: 838 Days
• Field of Search: 128/632-634, 351/205, 351/221
• US Class Current: 600/310
• CPC Class Codes: A61B 3/1233 for measuring blood flow, e.g. at the retina

Abstract

An apparatus for measuring blood flow in which an optical system guides a coherent light beam to impinge on a stationary measurement spot of a measurement plane of an in vivo tissue. A light-receiving optical system focuses a light image of the measurement plane in the vicinity of an image point conjugate with the stationary measurement spot. The light-receiving optical system shares at least part of the optical components of the guiding optical system. Photodetectors are disposed at prescribed positions perpendicular to the optical axis of the light-receiving optical system, and in the vicinity of the image point, for measuring light scattered from the in vivo tissue to provide blood flow information. The blood flow information is related to blood flowing at a depth within the in vivo tissue. A visible image of the measurement plane is converted into a video image. The blood flow information corresponding to the position of the stationary measurement spot is superimposed on the video image and displayed to obtain a composite visible image.

Claims

1. An apparatus for measuring a blood flow, comprising:

a scanning optical system having optical components for guiding a coherent light beam to impinge on a stationary measurement spot of a measurement plane of an in vivo tissue;

a light receiving optical system for focusing a light image of the measurement plane in the vicinity of an image point conjugate with the stationary measurement spot, the light image having an optical axis, and the light receiving optical system sharing at least a part of the optical components of the scanning optical system;

at least one photodetecting means disposed at prescribed positions perpendicular to the optical axis and in the vicinity of the image point for measuring light scattered from the in vivo tissue to provide blood flow information related to blood flowing at a depth within the in vivo tissue;

video imaging means for receiving a visible image of the measurement plane and converting it into a video image; and

image superimposing means for superimposing blood flow information corresponding to the position of the stationary measurement spot on the video image and displaying the superimposed blood flow information and video image as a composite visible image.

2. An apparatus as st forth in claim 1, wherein the scanning optical system includes a galvanoscanner which is shared by the light receiving optical system and which produces the blood flow information corresponding to the position of the stationary measurement spot.

3. An apparatus as set forth in claim 1, further comprising light deflecting means disposed between the scanning optical system and the in vivo tissue for transmitting the wavelength of the coherent light beam to the light receiving optical system and for reflecting light of other wavelengths toward the video imaging means.

4. An apparatus as set forth in claim 1, wherein the position of the stationary measurement spot is displayed on the composite visible image.

5. An apparatus as set forth in claim 1, further comprising means for calculating oxygen saturation of blood at a depth within the in vivo tissue on the basis of the blood flow information.

6. An apparatus as set out in claim 1, further comprising means for calculating erythrocyte flow velocity distribution at a given depth within the in vivo tissue on the basis of the blood flow information.

7. A method for measuring blood flow and displaying blood flow information, comprising the steps:

guiding a coherent light beam to impinge on a stationary measurement spot of a measurement plane of an in vivo tissue to obtain an image of the measurement plane of the in vivo tissue;

focusing the image of the measurement plane of the in vivo tissue about an image point which corresponds to the stationary measurement spot;

measuring coherent light scattered from the measurement plane of the in vivo tissue at the stationary measurement spot to obtain blood flow information related to flood flowing in the measurement plane of the in vivo tissue;

forming a visible image of the measurement plane and converting the visible image into a video image;

superimposing the blood flow information corresponding to the position of the stationary measurement spot on the video image; and

displaying the superimposed blood flow information and video image as a composite visible image.

8. A method according to claim 7, wherein the guiding step is carried out by a coherent light beam composed of coherent light of different wavelengths;

and the measuring step comprises measuring the amounts of coherent light of different wavelengths scattered from the measurement plane of the in vivo tissue at the stationary measurement spot to obtain spectral information indicative of oxygen saturation of the blood flowing in the measurement plane of the in vivo tissue.

9. A method according to claim 7, wherein the measuring step comprises measuring variation in the intensity of coherent light scattered from the measurement plane of the in vivo tissue at the stationary measurement spot to obtain blood flow information indicative of the blood flow velocity distribution at a given depth within the in vivo tissue.