Biological tissue adhesion
First Claim
1. A method for the application of gelatin-resorcinol aldehyde glue to a biological tissue surface, comprising:
- (i) applying a solution of gelatin-resorcinol to the surface to obtain a gelatin-resorcinol coated surface using a kit including a first container of a solution of gelatin-resorcinol and a second container of a solution of an aldehyde, the second container including means for aerosolizing the solution of aldehyde;
(ii) aerosolizing a solution of an aldehyde onto the gelatin-resorcinol coated surfaced wherein the aldehyde is an aqueous solution of approximately 25% glutaraldehyde and(iii) allowing the mixture of gelatin resorcinol and the aldehyde on the surface, obtained in step (ii), to polymerize.
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Accused Products
Abstract
The invention provides a method for the application of gelatin-resorcinol aldehyde glue to a surface, wherein a solution of gelatin-resorcinol is applied to the surface to obtain a gelatin-resorcinol coated surface. Subsequently, a solution of an aldehyde is aerosolized onto the gelatin-resorcinol coated surface. The mixture of gelatin-resorcinol and the aldehyde is then allowed to polymerize on the surface. The methods of the invention may be conveniently and efficiently used to apply gelatin-resorcinol aldehyde glue to high porosity vascular prostheses, either before or after implantation, to provide improved hemostasis. The aldehydes that may be utilized according to the methods of the invention may include formaldehyde, glutaraldehyde, or a combination thereof In one embodiment of the invention, the gelatin-resorcinol aldehyde glue may be conveniently provided in a kit that includes (a) a first container of a gelatin-resorcinol solution and (b) a second container of a solution of an aldehyde, the second container including means for aerosolizing the aldehyde solution. The methods of the invention may be used for the application of gelatin-resorcinol aldehyde glue in a wide variety of surgical procedures.
37 Citations
18 Claims
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1. A method for the application of gelatin-resorcinol aldehyde glue to a biological tissue surface, comprising:
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(i) applying a solution of gelatin-resorcinol to the surface to obtain a gelatin-resorcinol coated surface using a kit including a first container of a solution of gelatin-resorcinol and a second container of a solution of an aldehyde, the second container including means for aerosolizing the solution of aldehyde; (ii) aerosolizing a solution of an aldehyde onto the gelatin-resorcinol coated surfaced wherein the aldehyde is an aqueous solution of approximately 25% glutaraldehyde and (iii) allowing the mixture of gelatin resorcinol and the aldehyde on the surface, obtained in step (ii), to polymerize. - View Dependent Claims (2)
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3. A method for the application of gelatin-resorcinol aldehyde glue to a graft, comprising:
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(i) obtaining a graft; (ii) applying a solution of gelatin-resorcinol to the graft, obtained in step (i), to obtain a gelatin-resorcinol coated graft; (iii) aerosolizing a solution of an aldehyde onto the coated graft, obtained in step (ii), to obtain a gelatin-resorcinol aldehyde mixture on the graft; (iv) allowing the mixture on the graft, obtained in step (iii), to polymerize. - View Dependent Claims (4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17)
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18. A kit, for the application of gelatin-resorcinol aldehyde glue to a surface, comprising:
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(i) a first container including a solution of gelatin resorcinol; and (ii) a second container including a solution of an aldehyde and means for aerosolizing the solution of aldehyde wherein the aldehyde solution includes at least one aldehydes selected from the group consisting of formaldehyde and approximately 25% glutaraldehyde in an aqueous solution.
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Specification