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Method of synthesizing sulfurized oligonucleotide analogs

  • US 5,292,875 A
  • Filed: 08/27/1993
  • Issued: 03/08/1994
  • Est. Priority Date: 04/20/1990
  • Status: Expired due to Fees
First Claim
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1. A method of sulfurizing a phosphate or thiophosphite linkage in an oligonucleotide, the method comprising the step of reacting said phosphite or thiophosphite linkage with a thiophosphorus compound to form a phosphorothioate linkage or a phosphorodithioate linkage, respectively, wherein said thiophosphorus compound is selected from the group consisting of thiophosphoric acid disulfide, dithiophosphoric acid disulfide, thiophosphinic acid disulfide, and dithiophosphinic acid disulfide.

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