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Amphiphilic peptide compositions and analogues thereof

  • US 5,294,605 A
  • Filed: 07/08/1991
  • Issued: 03/15/1994
  • Est. Priority Date: 07/19/1990
  • Status: Expired due to Term
First Claim
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1. A process for inhibiting growth of a target cell comprising:

  • administering to a host a biologically active amphiphilic peptide, said peptide including the following structural formula;

    
    
    space="preserve" listing-type="equation">R.sub.1 -R.sub.1 -R.sub.2 -R.sub.1 -R.sub.1 -R.sub.2 -R.sub.2 -R.sub.1 -R.sub.1 -R.sub.2 -R.sub.2 -R.sub.1 -R.sub.2 -R.sub.2, wherein -R1 is a hydrophobic amino acid, and -R2 is a basic hydrophilic or neutral hydrophilic amino acid, said peptide being administered in an amount effective to inhibit growth of a target cell in a host, wherein said hydrophobic amino acids are selected from the group consisting of Ala, Cys, Phe, Gly, Ile, Leu, Met, methionine sulfoxide, Val, Trp, and Tyr;

    said basic hydrophilic amino acids are selected from the group consisting of Lys, Arg, His, orn, homoarginine 2,4-diaminobutyric acid, and p-aminophenylalanine; and

    said neutral hydrophilic amino acids are selected from the group consisting of Asn, Gln, Ser, and Thr.

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