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Thieno tetrahydropyridines useful as class III antiarrhythmic agents

  • US 5,294,621 A
  • Filed: 10/07/1992
  • Issued: 03/15/1994
  • Est. Priority Date: 10/07/1992
  • Status: Expired due to Term
First Claim
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1. A compound of the following formula:

  • ##STR36## where Ar'"'"' is selected from the group consisting of pyridine, thiophene, furan, pyrrole or ##STR37## R1 is hydrogen or C1 -C3 alkyl;

    R2 is hydrogen, C1 -C6 alkyl, C3 -C7 branched chain alkyl;

    R3 is hydrogen, C1 -C6 alkyl, C3 -C7 branched chain alkyl, aryl or substituted aryl wherein the aryl substituents are C1 -C6 alkyl or C1 -C6 alkoxy;

    R4 is hydrogen, C1 -C5 alkyl, C3 -C7 branched chain alkyl, halogen, C1 -C3 alkoxy, nitro, amino, imidazole, cyano, CO2 R1, SO2 R1, CF3, NHCOR8, NR7 SO2 R8, CH2 SO2 R1, CH2 PO(OR1)2 or CH2 -imidazole;

    X is (CH2)m NR7 CO, (CH2)m NR7 SO2 or (CH2)m NHCH2 ;

    ##STR38## R5 is hydrogen, halogen or nitro;

    R7 is hydrogen or C1 -C3 alkyl;

    R8 is hydrogen, CF3, C1 -C4 alkyl, C3 -C5 branched chain alkyl, aryl or substituted aryl;

    m is 2-4; and

    when R1 is alkyl and R2 is hydrogen and when R1 /R3 or R2 /R3 are both alkyl;

    R1 /R3 is cis or trans and R2 /R3 is cis or trans ##STR39##

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