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Wearable artificial pancreas

  • US 5,298,022 A
  • Filed: 01/04/1993
  • Issued: 03/29/1994
  • Est. Priority Date: 05/29/1989
  • Status: Expired due to Term
First Claim
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1. A device for the continuous quantitative determination of glucose in the blood of a diabetic patient over a period of 24-36 hours, which comprises a container for a saline solution containing heparin, a microdialyzing needle inserted into a vein of said diabetic patient, pumping means for injecting said solution through said microdialyzing needle which contains a semipermeable plastic hollow fiber membrane located on its outer surface whereby dialysis occurs between the blood in the vein and said solution and only glucose and other substances of low molecular weight below 100,000 daltons go through said semipermeable fiber membrane and the concentration of said glucose and other substances of low molecular weight below 100,000 daltons reaches an equilibrium which is proportional to the actual concentration of glucose in the blood, and a glucose-containing saline solution is obtained, said microdialyzing needle being provided with an outgoing conduit, said conduit leading to a sensor, said sensor comprising a platinum silver electrode and an enzymatic membrane containing glucose oxidase, said glucose containing saline solution goes into said conduit, oxidation of glucose to gluconic acid and hydrogen peroxide occurs and said hydrogen peroxide is decomposed with the liberation of two electrons whereby electric current is produced, the concentration of glucose in the blood is determined by determining the amount of current produced, without recirculation of blood, said glucose containing saline solution contains about 1/2-1/20 of the glucose concentration in the blood and said saline solution is discarded.

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