Method for continuous liberation of active constituents into water

• US 5,298,248 A
• Filed: 02/18/1992
• Issued: 03/29/1994
• Est. Priority Date: 09/11/1989
• Status: Expired due to Fees

• Current Assignee: Rhone-Poulenc Sante (Sanofi )
• Original Assignee: Rhone-Poulenc Sante (Sanofi )
• Inventors: Hugues, Porte, Ghislaine, Torres
• Primary Examiner(s): Page, Thurman K.
• Assistant Examiner(s): Harrison, Robert H.
• Application Number:
  US07/835,079
• Time in Patent Office: 770 Days
• Field of Search: 424/400, 424/424, 210/321.84, 215/261, 215/308, 215/310, 220/203, 220/367, 220/371, 220/373, 239/34, 239/57, 239/58, 422/102, 422/104, 604/892.1
• US Class Current: 424/400
• CPC Class Codes: A61K 31/07 Retinol compounds, e.g. vitamin A retinoic acids A61K31/203
• CPC Class Codes: A61K 31/23 of acids having a carboxyl group bound to a chain of seven or more carbon atoms
• CPC Class Codes: A61K 9/0004 Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
• CPC Class Codes: B01J 4/04 using osmotic pressure using membranes, porous plates
• CPC Class Codes: C02F 1/688 Devices in which the water progressively dissolves a solid compound
• CPC Class Codes: C02F 2103/42 from bathing facilities, e.g. swimming pools

Abstract

An apparatus is provided for continuous and regular liberation of active constituents into domestic water supplies. The apparatus comprises a receptacle having a body portion which is impermeable to water and to the active constituent. The receptacle is provided with an aperture closed by a membrane which is permeable to water and to the active constituent. An operculum surrounds the membrane to secure the membrane to the receptacle. The active constituent is provided into the receptacle and is released through the membrane in a controlled manner over an extended period of time. Preferably, the membrane has a mean pore diameter greater than 0.05 microns.

Claims

1. A method for continuous and regular liberation of a vitamin into a well or borehole, the method comprising the steps of:

introducing a vitamin into a receptacle having an aperture and a body portion, the body portion being formed of a material impermeable to water and to the vitamin;

closing the aperture with a membrane that is permeable to the vitamin and to water; and

immersing the receptacle in a well or borehole to permit diffusion of the vitamin through the membrane into the well or borehole over at least a month.

2. The method of claim 1, wherein the vitamin is vitamin A.

3. The method of claim 1, wherein the receptacle is immersed in the well or borehole in a fixed position.

4. The method of claim 1, wherein the vitamin is diffused into the water for a period of at least 3 months.

5. The method of claim 1, wherein the vitamin is diffused at a rate of between 5 and 50 mg per square centimeter of membrane per hour.