Dose setting and repeating syringe

• US 5,300,041 A
• Filed: 06/01/1992
• Issued: 04/05/1994
• Est. Priority Date: 06/01/1992
• Status: Expired due to Term

• Current Assignee: Eli Lilly and Company
• Original Assignee: Habley Medical Technology Corporation
• Inventors: Foster, Clark B., Smedley, William H., Haber, Terry M.
• Primary Examiner(s): YASKO JR, JOHN D
• Application Number:
  US07/893,417
• Time in Patent Office: 673 Days
• Field of Search: 604/207-211, 604/186, 604/187, 604/218, 604/219, 604/220, 604/232, 222/325, 222/326, 222/327, 222/391, 222/137
• US Class Current: 604/207
• CPC Class Codes: A61M 2005/2407 from the rear
• CPC Class Codes: A61M 2005/3128 Incorporating one-way valves, e.g. pressure-relief or non-return valves
• CPC Class Codes: A61M 5/204 connected to external reservoirs for multiple refilling
• CPC Class Codes: A61M 5/24 Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic ampoules or carpules A61J1/06
• CPC Class Codes: A61M 5/31536 Blocking means to immobilize a selected dose, e.g. to administer equal doses
• CPC Class Codes: A61M 5/31538 Permanent blocking, e.g. by medical personnel
• CPC Class Codes: A61M 5/31551 including axial movement of dose setting member
• CPC Class Codes: A61M 5/31561 using freely adjustable volume steps
• CPC Class Codes: A61M 5/31563 interacting with a displaceable stop member
• CPC Class Codes: A61M 5/3158 performed by axially moving actuator operated by user, e.g. an injection button

Abstract

A dose setting and repeating syringe (2) allows the user to simply and accurately make a series of injections, each of the same dose. The syringe includes a dose programming assembly which permits the dose for each injection to be preset by limiting the distance the piston (16) housed within the barrel (4) of the syringe moves. This can be done in various ways, such as mechanically, using a ratchet assembly (22, 28), or hydraulically, using a generally conventional cartridge (92) containing the pharmaceutical. A user-actuated dose plunger (40) is connected to the piston (16) and is used to drive the piston down the barrel. The axial movement of the dose plunger, and thus the dose dispensed, depends on the axial position of a dose ring (52) threaded to the proximal end (12) of the barrel.

Claims

1. A dose setting and repeating syringe comprising:

a barrel having a needle end, a proximal end and a hollow interior;

a piston within the interior for movement therein;

a variable volume chamber defined within the interior of the barrel between the piston and the needle end for containing a liquid pharmaceutical therein; and

a dose programming assembly including;

a dose setting element adjustably mounted to the barrel at a chosen dose setting; and

means for driving the piston towards the needle end equal distances during a series of injections without adjusting the dose setting element so to drive the same amount of the liquid pharmaceutical through the needle end during each injection, said amount being programmed for subsequent injections by the chosen dose setting of the dose setting element until the dose setting element is adjusted to an alternative dose setting.

2. The syringe of claim 1 wherein the dose setting element includes a dose ring threadably mounted to the proximal end of the barrel.

3. The syringe of claim 2 wherein the chosen dose setting corresponds to an axial position along the barrel.

9. The syringe of claim 1 wherein the dose programming assembly includes:

a cartridge containing a supply of the liquid pharmaceutical, the cartridge being housed within the interior of the barrel, the cartridge including a second piston therein, a proximal end and an open distal end, the first mentioned piston mounted to said distal end of the cartridge;

a first check valve between the variable volume chamber and the needle end of the barrel which permits fluid flow from said chamber and through said needle end but not the reverse;

a fluid path in the first mentioned piston coupling the liquid pharmaceutical in the cartridge to the variable volume chamber through the second check valve permitting said liquid pharmaceutical to flow from said cartridge to said chamber but not the reverse; and

an axially reciprocating drive element coupling the cartridge, through the second piston, to the dose setting element, the reciprocating axial movement of the drive element and the cartridge and first mentioned piston therewith being limited by the chosen dose setting of the dose setting element.

10. The syringe of claim 9 wherein the second check valve and the first mentioned piston are made as a one-piece molded part.

4. A dose setting and repeating syringe comprising:

a barrel having a needle end, a proximal end and a hollow interior;

a piston within the interior for movement therein;

a variable volume chamber defined within the interior of the barrel between the piston and the needle end for containing a liquid pharmaceutical therein; and

a dose programming assembly including;

a dose setting element adjustably mounted to the barrel at a chosen dose setting; and

means for driving the piston towards the needle end equal distances during a series of injections so to drive the same amount of the liquid pharmaceutical through the needle end during each injection, said amount determined by the chosen dose setting of the dose setting element, wherein the piston driving means includes;

a telescoping ratchet driver including a first ratchet element coupled to the piston and a second ratchet element ratchetly coupled to the first ratchet element and extending from said first ratchet element towards the distal end of the barrel; and

an axially reciprocating drive element coupling the second ratchet element to the dose setting element, the axial movement of the drive element and second ratchet element therewith towards the piston being limited by the chosen dose setting of the dose setting element.

5. The syringe of claim 4 wherein the dose programming assembly includes a dose setting key means for adjusting the chosen dose setting of the dose setting element.

6. The syringe of claim 5 wherein the reciprocating drive element includes an opening formed therein, the dose setting element includes a drive surface and the dose setting key means includes a drive element sized and positioned to pass through the opening in the reciprocating drive element and engage the drive surface of dose setting element so that by manipulating said dose setting key means the chosen dose setting can be changed.

7. The syringe of claim 6 wherein the opening in the reciprocating drive element incudes an axially extending slot.

8. The syringe of claim 4 wherein the second ratchet element includes a serrated outer surface.

11. A dose setting and repeating syringe comprising:

a barrel having a needle end, a proximal end and a hollow interior;

a piston within the interior for movement therein;

a variable volume chamber defined within the interior of the barrel between the piston and the needle end of containing a liquid pharmaceutical therein; and

a dose programming assembly including;

a dose setting element adjustably mounted to the barrel at a chosen dose setting;

means for driving the piston towards the needle end equal distances during a series of injections so to drive the same amount of the liquid pharmaceutical through the needle end during each injection, said amount determined by the chosen dose setting of the dose setting element, the piston driving means including;

a telescoping ratchet driver including a first ratchet element coupled to the piston and a second ratchet element ratchetly coupled to the first ratchet element and extending from said first ratchet element towards the distal end of the barrel; and

an axially reciprocating drive element coupling the second ratchet element to the dose setting element, the axial movement of the drive element and second ratchet element therewith towards the piston being limited by the chosen dose setting of the dose setting element;

a dose setting key means for adjusting the chosen dose setting of the dose setting element;

the reciprocating drive element including an opening formed therein, the dose setting element including a drive surface and the dose setting key means including a drive element sized and positioned to pass through the opening in the reciprocating drive element and engage the drive surface of dose setting element so that by manipulating said dose setting key means the chosen dose setting can be changed.

12. A dose setting and repeating syringe comprising:

a barrel having a needle end, a proximal end and a hollow interior;

a piston within the interior for movement therein;

a variable volume chamber defined within the interior of the barrel between the piston and the needle end for containing a liquid pharmaceutical therein;

a cartridge containing a supply of the liquid pharmaceutical, the cartridge being housed within the interior of the barrel, the cartridge including a second piston therein, a proximal end and an open distal end, the first mentioned piston mounted to said distal end of the cartridge;

a first check valve between the variable volume chamber and the needle end of the barrel which permits fluid flow from said chamber and through said needle end but not the reverse;

a fluid path in the first mentioned piston coupling the liquid pharmaceutical in the cartridge to the variable volume chamber through the second check value permitting said liquid pharmaceutical to flow from said cartridge to said chamber but not the reverse;

an axially reciprocating drive element coupling the cartridge to the dose setting element, the reciprocating axially movement of the drive element and the cartridge and first mentioned piston therewith, being limited by the chosen dose setting of the dose setting element; and

means for driving the piston towards the needle end equal distances during a series of injections so to drive the same amount of the liquid pharmaceutical through the needle end during each injection, said amount determined by the chosen dose setting of the dose setting element.