Apparatus and method for measuring, formatting and transmitting combined intracardiac impedance data and electrograms

• US 5,300,093 A
• Filed: 09/14/1992
• Issued: 04/05/1994
• Est. Priority Date: 09/14/1992
• Status: Expired due to Term

• Current Assignee: Pacesetter Incorporated (Abbott Laboratories)
• Original Assignee: Telectronics Pacing Systems, Inc (Abbott Laboratories)
• Inventors: Wells, Randy T., Koestner, Ken, Steinhaus, Bruce M.
• Primary Examiner(s): Kamm, William E.
• Application Number:
  US07/944,466
• Time in Patent Office: 568 Days
• Field of Search: 128/419 PG, 128/419 PT, 128/697, 128/734
• US Class Current: 607/32
• CPC Class Codes: A61B 5/053 Measuring electrical impedance or conductance of a portion of the body
• CPC Class Codes: A61B 5/08 Detecting, measuring or recording devices for evaluating the respiratory organs A61B5/0205 takes precedence
• CPC Class Codes: A61B 5/6869 Heart
• CPC Class Codes: A61N 1/36521 the parameter being derived from measurement of an electrical impedance

Abstract

A patient-implantable cardiac stimulation apparatus adapted to measure body impedance, derive at least one physiological parameter from the impedance measurement, sample a time sequence of the physiological parameter and transmit the sequence to an external monitoring device for display and analysis. The apparatus may also sense intracardiac electrograms while it is measuring body impedance and deriving the physiological parameter, in which case it formats and transmits a combined intracardiac electrogram and physiological signal to the monitoring device.

Claims

1. A cardiac apparatus, comprising:

means for measuring impedance within a patient'"'"'s body;

means for deriving at least one time-varying physiological parameter a function of the measured impedance;

means for selecting samples of said at least one time-varying physiological parameter;

means for formatting the selected samples into a time sequence of digital samples representing the amplitude of said at least one time-varying physiological parameter;

an external monitoring device;

means for transmitting said formatted samples to said external monitoring device;

means for measuring cardiac electrical signals within the patient'"'"'s body;

means for selecting samples of said cardiac electrical signals;

means for formatting the selected electrical signals into a time sequence of digital samples representing the amplitude of said cardiac electrical signals; and

means for combining said at least one physiological parameter time sequence with said cardiac electrical signal time sequences into a combined sequence of digital samples, wherein said transmitting means transmits said combined sequence of digital samples to said external monitoring device, including;

means for encoding said at least one physiological parameter time sequence into a serial data stream of signal bits,

means for encoding said cardiac electrical signal time sequence into a time sequence of multiple-bit digital samples wherein the value of each multiple-bit sample corresponds to an instantaneous amplitude of the cardiac electrical signal, and

means for truncating the multiple-bit digital samples by one bit for each of said at least one physiological parameter sequence and replacing each truncated bit with the single bit of said at least one time varying physiological parameter serial data stream of single bits.

2. An apparatus in accordance with claim 1, wherein said combining means includes means for restoring cardiac electrical signal sample bits truncated and replaced by said physiological parameter serial data stream of single bits.

3. An apparatus in accordance with claim 2, wherein said means for restoring truncated and replaced cardiac electrical signal sample bits further comprises:

means for storing the values of bits truncated from preceding time samples of said multiple-bit digital samples, and

means for adding the values of said stored truncated bits into subsequent time samples of said multiple-bit digital samples.

4. An apparatus according to claim 3, further including:

two electrodes, coupled to said impedance measuring means, each for interconnection to the patient'"'"'s body; and

wherein;

said impedance measuring means includes;

means for applying a frequency-controlled, time-varying current between said two electrodes, and

means for measuring the voltage resulting from the application of said current; and

further including;

means for controlling said impedance measuring means, having a mode of operation of setting the timing of, and thereby limiting, the frequency components of said applied current to lie within at least one predetermined subrange of frequencies such that the measured voltage within each subrange of frequencies corresponds to a measurement of at least one said time varying physiological parameter.

5. An apparatus according to claim 4, wherein:

said current applying means, in response to commands from said controlling means, has a mode of operation of generating time varying measuring current in the form of short duration current pulses having pulse durations in a range of approximately 50 to 100 microseconds; and

said resultant voltage is provided to said physiological parameter deriving means which derives a respiration signal therefrom.

6. An apparatus in accordance with claim 5, wherein said apparatus further includes a cardiac stimulation pulse generator and means for deriving a cardiac stimulation control signal for controlling said pulse generator, and wherein said deriving means further comprises:

means for analyzing said respiration signal over time to determine a respiratory tidal volume parameter and to detect respiratory signal zero crossings indicative of a respiratory rate parameter;

means for determining a respiratory minute volume parameter as a function of the tidal volume parameter and the respiratory rate parameter;

means for ascertaining an indication of the time average of said respiratory minute volume parameter over both a short time period and a long time period to determine a short-term average respiration signal and a long-term average respiration signal, respectively; and

means for determining a metabolic demand pacing rate as a function of the difference between said short-term average respiration signal and said long-term average respiration signal.

7. An apparatus according to claim 6, wherein:

said physiological parameter deriving means has a mode of operation wherein it derives at least one physiological parameter which is selected from the group of parameters which includes;

the respiration signal,

the respiratory tidal volume parameter,

the respiration rate parameter,

the respiratory minute volume parameter,

the short-term average respiration signal, and

the long-term average respiration signal;

said formatting means formats said at least one physiological parameter;

said transmitting means transmits said at least one physiological parameter; and

said external monitoring device receives and displays said at least one physiological parameter.

8. An apparatus according to claim 5, wherein:

said physiological parameter deriving means derives at least two physiological parameters;

said current applying means, in response to commands from said controlling means, has a mode of operation wherein it generates a third time varying measuring current in the form of short duration current pulses having pulse durations shorter than approximately 70 nanoseconds, and

said respective third voltage is provided to said physiological parameter deriving means which derives a patient motion signal therefrom.

9. An apparatus according to claim 5 wherein:

said current applying means, in response to commands from said controlling means, has a mode of operation wherein it generates the time varying measuring current pulses having pulse durations longer than 300 nanoseconds; and

said resultant voltage measured by said measuring means is provided to said physiological parameter deriving means, which derives a cardiac hemodynamic signal therefrom.

10. An apparatus according to claim 5 wherein:

said physiological parameter deriving means derives at least two physiological parameters;

said current applying means, in response to commands from said controlling means, has a mode of operation wherein it generates a second time varying measuring current in the form of short duration current pulses having pulse durations shorter than approximately 70 nanoseconds; and

said measuring means measures a second voltage that is provided to said physiological parameter deriving means, which derives a patient motion signal therefrom.

11. An apparatus according to claim 4, wherein:

said physiological parameter deriving means derives at least two physiological parameters;

said current applying means, in response to commands from said controlling means, has a mode of operation of generating a second time-varying measuring current in the form of short duration current pulses having pulse durations longer than approximately 300 nanoseconds; and

said respective second voltage is provided to said physiological parameter deriving means which derives a cardiac hemodynamic signal therefrom.

12. An apparatus according to claim 11, wherein:

said current applying means in response to commands from said controlling means, has a mode of operation wherein it generates the time varying measuring current in the form of short duration current pulses having pulse durations shorter than approximately 70 nanoseconds; and

the voltage measured by said measuring means is provided to said physiological parameter deriving means, which derives a patient motion signal therefrom.

13. An apparatus according to claim 11 further including;

two electrodes, coupled to said impedance measuring means, each for interconnection to the patient'"'"'s body, for sensing signals and for delivering stimulation pulses; and

wherein;

said impedance measuring means further includes;

means for applying a frequency controlled, time varying current between said two electrodes, and

means for measuring a voltage in response to the application of the measuring current; and

further including;

means for controlling said measuring means, operable to set the timing of, and to thereby limit, the frequency components of the applied time varying current to lie within at least one predetermined subrange of frequencies such that the measured voltage within each subrange of frequencies corresponds to a measurement of said time varying physiological parameter; and

means for deriving said at least one time varying physiological parameter from the measured voltage corresponding to the predetermined subrange of frequencies.

14. A method for monitoring at least one time varying physiological parameter sensed by a device implanted in the patient, said device having:

means for monitoring a physiological signal, and

means for transmitting a representation of the physiological signal to an external monitoring device for display;

said method comprising;

measuring an impedance within the body of the patient;

deriving at least one time varying physiological parameter as a function of the measured impedance;

selecting samples of said at least one time varying physiological parameter;

formatting said samples of said parameter into a digital time sequence of samples representing the amplitude of said parameter;

sensing cardiac electrical signals;

sampling and formatting said cardiac electrical signals to generate a time sequence of digital samples representing the amplitude of said cardiac electrical signals; and

combining said at least one physiological parameter time sequence with said cardiac electrical signal time sequence into a combined sequence of digital samples and transmitting said combined sequence of digital samples to said external monitor, by;

encoding each of said at least one physiological parameter time sequence samples into a serial data stream of single bits,

encoding said cardiac electrical signal time sequence into a time sequence of multiple-bit samples wherein the value of each multiple-bit sample corresponds to an instantaneous amplitude of the cardiac electrical signal, and

truncating the multiple-bit digital samples by one bit for each of said at least one physiological parameter sequence and replacing each truncated bit with the single bit of said at least one time varying, physiological parameter serial data stream of single bits.

15. A method in accordance with claim 14, wherein said combining step includes the sub-step of restoring cardiac electrical signal sample bits truncated and replaced by said physiological parameter serial data stream of bits.

16. A method in accordance with claim 15, wherein said sub-step of restoring truncated and replaced cardiac electrical signal sample bits further comprises the sub-steps of:

storing the values of bits truncated from preceding time samples of said multiple-bit digital samples, and

adding the values of said stored truncated bits into subsequent time samples of said multiple-digital samples.

17. A method according to claim 16, said implanted device having at least two electrodes for sensing signals and delivering stimulation pulses, and wherein:

said impedance measuring step includes the sub-steps of;

applying a frequency controlled, time varying current between two of said at least two electrodes, and

measuring the voltage responding to said application of said measuring current; and

wherein said method further comprises;

controlling said impedance measuring step to set the timing of, and to thereby limit, the frequency components of the applied time varying current to lie within at least one predetermined subrange of frequencies such that the measured voltage within each subrange of frequencies corresponds to a measurement of said time varying physiological parameter; and

deriving said at least one time varying physiological parameter from the measured voltage corresponding to the predetermined subrange of frequencies.

18. A method according to claim 14, said implanted device having at least two electrodes for sensing signals and delivering stimulation pulses, and wherein:

said impedance measuring step includes the sub-steps of;

applying a frequency controlled, time varying current between two of said at least two electrodes, and

measuring a voltage responding to said application of said measuring current; and

wherein said method further comprises;

controlling said impedance measuring step to set the timing of, and to thereby limit, the frequency components of the applied time varying current to lie within at least one predetermined subrange of frequencies such that the measured voltage within each subrange of frequencies corresponds to a measurement of said time varying physiological parameter; and

deriving said at least one time varying physiological parameter from the measured voltage corresponding to the predetermined subrange of frequencies.