Subconjunctival implants for ocular drug delivery

• US 5,300,114 A
• Filed: 08/10/1992
• Issued: 04/05/1994
• Est. Priority Date: 05/04/1992
• Status: Expired due to Term

• Current Assignee: Allergan, Inc. (Canada) (Abbvie Incorporated)
• Original Assignee: Allergan, Inc. (Canada) (Abbvie Incorporated)
• Inventors: Gwon, Arlene E., Meadows, David
• Primary Examiner(s): Green, Randall L.
• Assistant Examiner(s): BRITTINGHAM, DEBRA
• Application Number:
  US07/926,402
• Time in Patent Office: 603 Days
• Field of Search: 623/5, 623/6, 623/4, 604/294-302, 604/890.1, 604/891.1, 604/892.1, 424/7.1, 424/9, 424/422, 424/423, 424/424, 514/912, 356/317, 356/318, 356/417
• US Class Current: 623/4.1
• CPC Class Codes: A61F 9/0017 implantable in, or in contact with, the eye, e.g. ocular inserts
• CPC Class Codes: A61K 9/0051 Ocular inserts, ocular implants
• CPC Class Codes: A61M 31/002 Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time artificial gland structures or devices A61F2/022; intra-uterine contraceptive devices A61F6/14; tampons for introducing into the vagina A61F13/20, A61L15/00; suppositories or bougies for intra-vaginal or intra-uterine application A61K9/02; physical forms of medicinal preparations for sustained or differential drug release A61K9/20, A61K9/50

Abstract

A system for providing controlled release of an active agent in an eye includes a device with a shape thereof for enabling placement of the device under a conjunctiva of an eye and additionally preventing migration of the device in the eye after placement of the device under the conjunctiva. The device may be formed of a material permeable to the passage of an agent disposed in said device. In addition, a tracer may be incorporated in the device to enable visual indication of the amount of active agent in said device when said device is disposed under the conjunctiva. To selectively treat specific areas of the eye, an impermeable layer may be provided for preventing diffusion of the active agent from a selected area of the device.

Claims

1. A subconjunctival ocular implant comprising:

a supply of an active agent

means for supporting said active agent and enabling diffusion of the active agent out of the implant at a selected rate;

means for providing visual indication of the amount of active agent in said ocular inplant when said ocular implant is disposed under a conjunctiva of an eye.

2. A subconjunctival ocular implant according to claim 14;

wherein said means for supporting said active agent and enabling diffusion of the active agent out of the implant at a selected rate comprises a matrix comprising a polymer, permeable by said active agent, and an impermeable layer, disposed on said matrix, for preventing diffusion of the active agent from a selected area on the means for supporting said active agent.

3. The subconjunctival ocular implant according to claim 2 wherein said impermeable layer is disposed on said matrix for enabling delivery of active agent only to posterior segments of an eye.

4. The subconjunctival ocular implant, according to claim 3, wherein said impermeable layer is disposed on said matrix for enabling delivery of active agent only from a side of the matrix adjacent to a sclera in order to decrease systemic drug adsorption through conjunctival blood vessels.

5. The subconjunctival ocular implant according to claim 1 wherein said means for supporting the active agent comprises a flexible body formed of a polymeric material.

6. The subconjunctival ocular implant according to claim 5 further comprising means for preventing diffusion of the active agent out of the implant from a selected area of the implant.

7. The subconjunctival ocular implant according to claim 6 wherein the selected area comprises a surface on said subconjunctival ocular implant facing said conjunctiva when said subconjunctival ocular implant is disposed under the conjunctiva.

8. The subconjunctival ocular implant according to claim 7 wherein means for providing visual indication comprises a fluorescent tracer.

9. The subconjunctival ocular implant according to claim 8 further comprising means for preventing migration of said implant in the eye after placement of the implant under the eye conjunctiva.

10. The subconjunctival ocular implant according to claim 9 wherein said means for preventing migration of the implant in an eye comprises means for defining an arcuate exterior shape of the implant.

11. The subconjunctival implant according to claim 10 wherein the flexible body shape comprises a crescent.

12. The subconjunctival ocular implant according to claim 9 wherein said means for preventing migration of the implant in an eye comprises means for enabling the implant to be sutured to the sclera.

13. The subconjunctival ocular implant according to claim 9 wherein said means for preventing migration of the implant in an eye comprises means for temporarily bonding the implant to a sclera.

14. The subconjunctival ocular implant according to claim 1 wherein said means for providing visual indication comprises a fluorescent tracer.

15. The subconjunctival ocular implant according to claim 14 wherein the means for supporting said active agent comprises a flexible body formed of a polymeric material permeable to passage of the active agent and having a layer impermeable to the active agent on a side thereof.