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Ambulatory clearance function monitor

  • US 5,301,673 A
  • Filed: 11/18/1991
  • Issued: 04/12/1994
  • Est. Priority Date: 11/18/1991
  • Status: Expired due to Term
First Claim
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1. A method for measuring depletion of a detectable substance from a subject'"'"'s body, comprisingproviding a detectable substance to a subject, said detectable substance capable of equilibrating in a subject'"'"'s extracellular fluid,allowing said detectable substance to equilibrate in said subject'"'"'s extracellular fluid forming equilibrated extracellular fluid,situating a detector on a portion of said subject'"'"'s body having a defined constant volume of said equilibrated extracellular fluid,enclosing said detector and said portion of said subject'"'"'s body in a barrier that is substantially opaque to said detectable substance such that only said defined constant volume of said equilibrated extracellular fluid within said body portion is detected by said detector,measuring a response of said detector to said equilibrated detectable substance, said response indicative of the quantity of said detectable substance within said defined constant volume of said equilibrated extracellular fluid, anddetermining the depletion of said detectable substance from a change in quantity of said substance measured within said defined constant volume of said equilibrated extracellular fluid.

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